Remission and long-term remission of pediatric-onset systemic lupus erythematosus
ObjectivesSystemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse clinical presentations and prognoses. Remission can be achieved with or without glucocorticoid (GC) use, and several recent studies have suggested that long-term remission can be achieved in a small portion of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1272065/full |
| _version_ | 1797647667734511616 |
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| author | Yi-Chieh Chen Chiann-Yi Hsu Ming-Chin Tsai Lin-Shien Fu Lin-Shien Fu Lin-Shien Fu Yung-Chieh Huang Yung-Chieh Huang Yung-Chieh Huang Yung-Chieh Huang |
| author_facet | Yi-Chieh Chen Chiann-Yi Hsu Ming-Chin Tsai Lin-Shien Fu Lin-Shien Fu Lin-Shien Fu Yung-Chieh Huang Yung-Chieh Huang Yung-Chieh Huang Yung-Chieh Huang |
| author_sort | Yi-Chieh Chen |
| collection | DOAJ |
| description | ObjectivesSystemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse clinical presentations and prognoses. Remission can be achieved with or without glucocorticoid (GC) use, and several recent studies have suggested that long-term remission can be achieved in a small portion of patients. Nevertheless, few studies have investigated remission or long-term remission in the pediatric-onset SLE subgroup. This study analyzed the characteristics and factors associated with long-term remission and GC use in pediatric-onset SLE.MethodsWe enrolled 226 patients aged <18 years who received a diagnosis of SLE between January 2006 and December 2016. Three remission condition groups were defined: (A) complete remission, (B) clinical remission off GCs, and (C) clinical remission on GCs. Long-term remission was defined as remission for more than 5 years. We analyzed the treatment durations before remission, durations of remission, and risk factors for non-remission with persistent GC use.ResultsDuring follow-up, 8 patients (3.5%) achieved complete remission, 35 patients (15.5%) achieved clinical remission off GCs, and 93 patients (41.2%) achieved clinical remission on GCs. In groups A, B, and C, 12.5%, 68.6%, and 65.6% of patients, respectively, remained in remission for >1 year.ConclusionThis study assessed remission of pediatric-onset SLE. Up to 60.2% of patients had clinical remission after treatment, and 19% of patients achieved remission off GCs. Long-term remission is rarer in pediatric-onset SLE than in adult-onset SLE. |
| first_indexed | 2024-03-11T15:19:52Z |
| format | Article |
| id | doaj.art-1dabab14505e49a38a78c0a05303d64c |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-03-11T15:19:52Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-1dabab14505e49a38a78c0a05303d64c2023-10-28T21:05:08ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-10-011110.3389/fped.2023.12720651272065Remission and long-term remission of pediatric-onset systemic lupus erythematosusYi-Chieh Chen0Chiann-Yi Hsu1Ming-Chin Tsai2Lin-Shien Fu3Lin-Shien Fu4Lin-Shien Fu5Yung-Chieh Huang6Yung-Chieh Huang7Yung-Chieh Huang8Yung-Chieh Huang9Department of Pediatrics, Taichung Veterans General Hospital, Taichung, TaiwanBiostatistics Task Force of Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Pediatrics, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Pediatrics, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Pediatrics, National Yang Ming Chiao Tung University, Taipei, TaiwanDepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, TaiwanDepartment of Pediatrics, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Pediatrics, National Yang Ming Chiao Tung University, Taipei, TaiwanDepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, TaiwanProgram in Translational Medicine, National Chung Hsing University, Taichung, TaiwanObjectivesSystemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse clinical presentations and prognoses. Remission can be achieved with or without glucocorticoid (GC) use, and several recent studies have suggested that long-term remission can be achieved in a small portion of patients. Nevertheless, few studies have investigated remission or long-term remission in the pediatric-onset SLE subgroup. This study analyzed the characteristics and factors associated with long-term remission and GC use in pediatric-onset SLE.MethodsWe enrolled 226 patients aged <18 years who received a diagnosis of SLE between January 2006 and December 2016. Three remission condition groups were defined: (A) complete remission, (B) clinical remission off GCs, and (C) clinical remission on GCs. Long-term remission was defined as remission for more than 5 years. We analyzed the treatment durations before remission, durations of remission, and risk factors for non-remission with persistent GC use.ResultsDuring follow-up, 8 patients (3.5%) achieved complete remission, 35 patients (15.5%) achieved clinical remission off GCs, and 93 patients (41.2%) achieved clinical remission on GCs. In groups A, B, and C, 12.5%, 68.6%, and 65.6% of patients, respectively, remained in remission for >1 year.ConclusionThis study assessed remission of pediatric-onset SLE. Up to 60.2% of patients had clinical remission after treatment, and 19% of patients achieved remission off GCs. Long-term remission is rarer in pediatric-onset SLE than in adult-onset SLE.https://www.frontiersin.org/articles/10.3389/fped.2023.1272065/fullpediatricsprognosisremissionsystemic lupus erythematosusglucocorticoid |
| spellingShingle | Yi-Chieh Chen Chiann-Yi Hsu Ming-Chin Tsai Lin-Shien Fu Lin-Shien Fu Lin-Shien Fu Yung-Chieh Huang Yung-Chieh Huang Yung-Chieh Huang Yung-Chieh Huang Remission and long-term remission of pediatric-onset systemic lupus erythematosus Frontiers in Pediatrics pediatrics prognosis remission systemic lupus erythematosus glucocorticoid |
| title | Remission and long-term remission of pediatric-onset systemic lupus erythematosus |
| title_full | Remission and long-term remission of pediatric-onset systemic lupus erythematosus |
| title_fullStr | Remission and long-term remission of pediatric-onset systemic lupus erythematosus |
| title_full_unstemmed | Remission and long-term remission of pediatric-onset systemic lupus erythematosus |
| title_short | Remission and long-term remission of pediatric-onset systemic lupus erythematosus |
| title_sort | remission and long term remission of pediatric onset systemic lupus erythematosus |
| topic | pediatrics prognosis remission systemic lupus erythematosus glucocorticoid |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1272065/full |
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