Syngeneic mouse model of human HER2+ metastatic breast cancer for the evaluation of trastuzumab emtansine combined with oncolytic rhabdovirus

Syngeneic mouse model of human HER2+ metastatic breast cancer for the evaluation of trastuzumab emtansine combined with oncolytic rhabdovirus

BackgroundEstablished mouse models of HER2+ cancer are based on the over-expression of rodent Neu/Erbb2 homologues, which are incompatible with human HER2 (huHER2) targeted therapeutics. Additionally, the use of immune-deficient xenograft or transgenic models precludes assessment of native anti-tumo...

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Bibliographic Details
Main Authors: Zaid Taha, Mathieu J.F. Crupi, Nouf Alluqmani, Faiha Fareez, Kristy Ng, Judy Sobh, Emily Lee, Andrew Chen, Max Thomson, Marcus M. Spinelli, Carolina S. Ilkow, John C. Bell, Rozanne Arulanandam, Jean-Simon Diallo
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
mouse model
HER2
immunotherapy
oncolytic virus
VSVΔ51
antibody-drug conjugate
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1181014/full

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