Causal contribution and dynamical encoding in the striatum during evidence accumulation
A broad range of decision-making processes involve gradual accumulation of evidence over time, but the neural circuits responsible for this computation are not yet established. Recent data indicate that cortical regions that are prominently associated with accumulating evidence, such as the posterio...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2018-08-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/34929 |
| _version_ | 1818028430638186496 |
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| author | Michael M Yartsev Timothy D Hanks Alice Misun Yoon Carlos D Brody |
| author_facet | Michael M Yartsev Timothy D Hanks Alice Misun Yoon Carlos D Brody |
| author_sort | Michael M Yartsev |
| collection | DOAJ |
| description | A broad range of decision-making processes involve gradual accumulation of evidence over time, but the neural circuits responsible for this computation are not yet established. Recent data indicate that cortical regions that are prominently associated with accumulating evidence, such as the posterior parietal cortex and the frontal orienting fields, may not be directly involved in this computation. Which, then, are the regions involved? Regions that are directly involved in evidence accumulation should directly influence the accumulation-based decision-making behavior, have a graded neural encoding of accumulated evidence and contribute throughout the accumulation process. Here, we investigated the role of the anterior dorsal striatum (ADS) in a rodent auditory evidence accumulation task using a combination of behavioral, pharmacological, optogenetic, electrophysiological and computational approaches. We find that the ADS is the first brain region known to satisfy the three criteria. Thus, the ADS may be the first identified node in the network responsible for evidence accumulation. |
| first_indexed | 2024-12-10T05:03:40Z |
| format | Article |
| id | doaj.art-1daf52b9fc5b47609d3f06ac51b4d711 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-12-10T05:03:40Z |
| publishDate | 2018-08-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-1daf52b9fc5b47609d3f06ac51b4d7112022-12-22T02:01:19ZengeLife Sciences Publications LtdeLife2050-084X2018-08-01710.7554/eLife.34929Causal contribution and dynamical encoding in the striatum during evidence accumulationMichael M Yartsev0https://orcid.org/0000-0003-0952-2801Timothy D Hanks1https://orcid.org/0000-0003-4147-4475Alice Misun Yoon2https://orcid.org/0000-0001-7832-2796Carlos D Brody3https://orcid.org/0000-0002-4201-561XPrinceton Neuroscience Institute, Princeton, United States; Department of Bioengineering, Helen Wills Neuroscience Institute, Berkeley, United StatesPrinceton Neuroscience Institute, Princeton, United States; Department of Neurology, University of California, Davis, Sacramento, United States; Center for Neuroscience, University of California, Davis, Davis, United StatesPrinceton Neuroscience Institute, Princeton, United StatesPrinceton Neuroscience Institute, Princeton, United States; Howard Hughes Medical Institute, Maryland, United StatesA broad range of decision-making processes involve gradual accumulation of evidence over time, but the neural circuits responsible for this computation are not yet established. Recent data indicate that cortical regions that are prominently associated with accumulating evidence, such as the posterior parietal cortex and the frontal orienting fields, may not be directly involved in this computation. Which, then, are the regions involved? Regions that are directly involved in evidence accumulation should directly influence the accumulation-based decision-making behavior, have a graded neural encoding of accumulated evidence and contribute throughout the accumulation process. Here, we investigated the role of the anterior dorsal striatum (ADS) in a rodent auditory evidence accumulation task using a combination of behavioral, pharmacological, optogenetic, electrophysiological and computational approaches. We find that the ADS is the first brain region known to satisfy the three criteria. Thus, the ADS may be the first identified node in the network responsible for evidence accumulation.https://elifesciences.org/articles/34929decision makingstriatumrat |
| spellingShingle | Michael M Yartsev Timothy D Hanks Alice Misun Yoon Carlos D Brody Causal contribution and dynamical encoding in the striatum during evidence accumulation eLife decision making striatum rat |
| title | Causal contribution and dynamical encoding in the striatum during evidence accumulation |
| title_full | Causal contribution and dynamical encoding in the striatum during evidence accumulation |
| title_fullStr | Causal contribution and dynamical encoding in the striatum during evidence accumulation |
| title_full_unstemmed | Causal contribution and dynamical encoding in the striatum during evidence accumulation |
| title_short | Causal contribution and dynamical encoding in the striatum during evidence accumulation |
| title_sort | causal contribution and dynamical encoding in the striatum during evidence accumulation |
| topic | decision making striatum rat |
| url | https://elifesciences.org/articles/34929 |
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