Preeclampsia and level of oxidative stress in the first trimester of pregnancy
Background/Aim. Preeclampsia (PE) is a multisystemic syndrome that complicates 5–8% of all pregnancies. The aim of this study was to evaluate the biochemical parameters of oxidative stress in the first trimester of pregnancy in patients with preeclampsia, with the purpose of comparing the level of o...
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2017-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2017/0042-84501600251B.pdf |
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| author | Bogavac Mirjana Jakovljević Ana Stajić Zoran Nikolić Aleksandra Milošević-Tošić Mirjana Dejanović Jadranka Lozanov-Crvenković Zagorka |
| author_facet | Bogavac Mirjana Jakovljević Ana Stajić Zoran Nikolić Aleksandra Milošević-Tošić Mirjana Dejanović Jadranka Lozanov-Crvenković Zagorka |
| author_sort | Bogavac Mirjana |
| collection | DOAJ |
| description | Background/Aim. Preeclampsia (PE) is a multisystemic syndrome that complicates 5–8% of all pregnancies. The aim of this study was to evaluate the biochemical parameters of oxidative stress in the first trimester of pregnancy in patients with preeclampsia, with the purpose of comparing the level of oxidative stress with normal pregnancy. Methods. The study was conducted as a prospective study. It included totally 107 pregnant women divided into two groups. In the study group (n = 33) there were women who developed preeclampsia in the current pregnancy. The control group (n = 74) included healthy pregnant women. Blood samples were taken between 11th and 14th weeks of gestation, and the values of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and total antioxidant status (TAS) were determined in serum by enzymatic colorimetric methods. Results. The values of SOD and GHS-Px were statistically higher in the study group, while the values of TAS were statistically higher in the control group. The level of TAS inversely correlated with GSH-Px and SOD, but there is no statistically significant correlation between GSHPx and SOD in the study group. Conclusion. The results of this study suggest a higher level of oxidative stress in the first trimester of pregnancy with preeclampsia, which may indicate that the initiation and development of pathophysiological processes underlying preeclampsia start much earlier than the clinical syndrome exhibit. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 174019] |
| first_indexed | 2024-12-22T07:45:50Z |
| format | Article |
| id | doaj.art-1db050f51d8c48e297b02e48f3938d46 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 2406-0720 |
| language | English |
| last_indexed | 2024-12-22T07:45:50Z |
| publishDate | 2017-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-1db050f51d8c48e297b02e48f3938d462022-12-21T18:33:38ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502406-07202017-01-0174763363810.2298/VSP150517251B0042-84501600251BPreeclampsia and level of oxidative stress in the first trimester of pregnancyBogavac Mirjana0Jakovljević Ana1Stajić Zoran2Nikolić Aleksandra3Milošević-Tošić Mirjana4Dejanović Jadranka5Lozanov-Crvenković Zagorka6Clinical Centre of Vojvodina, Department of Obstetrics and Gynecology, Novi Sad + Faculty of Medicine, Novi SadMedical Faculty, Novi Sad + Clinical Centre of Vojvodina, Centre for Laboratory Medicine, Novi SadInstitute for Health Protection of the Ministry of Interior, Department of Internal Medicine, Division of Cardiology, BelgradeMedical Faculty, Novi Sad + Clinical Centre of Vojvodina, Emergency Centre, Novi SadMedical Faculty, Novi Sad + Faculty of Science, Novi SadMedical Faculty, Novi Sad + Clinic of Cardiology, Sremska KamenicaMedical Faculty, Novi Sad + Faculty of Science, Novi SadBackground/Aim. Preeclampsia (PE) is a multisystemic syndrome that complicates 5–8% of all pregnancies. The aim of this study was to evaluate the biochemical parameters of oxidative stress in the first trimester of pregnancy in patients with preeclampsia, with the purpose of comparing the level of oxidative stress with normal pregnancy. Methods. The study was conducted as a prospective study. It included totally 107 pregnant women divided into two groups. In the study group (n = 33) there were women who developed preeclampsia in the current pregnancy. The control group (n = 74) included healthy pregnant women. Blood samples were taken between 11th and 14th weeks of gestation, and the values of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and total antioxidant status (TAS) were determined in serum by enzymatic colorimetric methods. Results. The values of SOD and GHS-Px were statistically higher in the study group, while the values of TAS were statistically higher in the control group. The level of TAS inversely correlated with GSH-Px and SOD, but there is no statistically significant correlation between GSHPx and SOD in the study group. Conclusion. The results of this study suggest a higher level of oxidative stress in the first trimester of pregnancy with preeclampsia, which may indicate that the initiation and development of pathophysiological processes underlying preeclampsia start much earlier than the clinical syndrome exhibit. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 174019]http://www.doiserbia.nb.rs/img/doi/0042-8450/2017/0042-84501600251B.pdfpregnancy complicationspre-eclampsiaoxidative stresssuperoxide dismutaseglutathione peroxidasesensitivity and specificity |
| spellingShingle | Bogavac Mirjana Jakovljević Ana Stajić Zoran Nikolić Aleksandra Milošević-Tošić Mirjana Dejanović Jadranka Lozanov-Crvenković Zagorka Preeclampsia and level of oxidative stress in the first trimester of pregnancy Vojnosanitetski Pregled pregnancy complications pre-eclampsia oxidative stress superoxide dismutase glutathione peroxidase sensitivity and specificity |
| title | Preeclampsia and level of oxidative stress in the first trimester of pregnancy |
| title_full | Preeclampsia and level of oxidative stress in the first trimester of pregnancy |
| title_fullStr | Preeclampsia and level of oxidative stress in the first trimester of pregnancy |
| title_full_unstemmed | Preeclampsia and level of oxidative stress in the first trimester of pregnancy |
| title_short | Preeclampsia and level of oxidative stress in the first trimester of pregnancy |
| title_sort | preeclampsia and level of oxidative stress in the first trimester of pregnancy |
| topic | pregnancy complications pre-eclampsia oxidative stress superoxide dismutase glutathione peroxidase sensitivity and specificity |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2017/0042-84501600251B.pdf |
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