Alterations in lipid metabolism and antioxidant status in lichen planus
Background: Lichen planus (LP), a T-cell-mediated inflammatory disorder, wherein inflammation produces lipid metabolism disturbances, is linked to increase in cardiovascular (CV) risk with dyslipidemia. Increased reactive oxygen species and lipid peroxides have also been implicated in its pathogenes...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Indian Journal of Dermatology |
| Subjects: | |
| Online Access: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2015;volume=60;issue=5;spage=439;epage=455;aulast= |
| _version_ | 1818693682767855616 |
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| author | Falguni H Panchal Somshukla Ray Renuka P Munshi Supriya S Bhalerao Chitra S Nayak |
| author_facet | Falguni H Panchal Somshukla Ray Renuka P Munshi Supriya S Bhalerao Chitra S Nayak |
| author_sort | Falguni H Panchal |
| collection | DOAJ |
| description | Background: Lichen planus (LP), a T-cell-mediated inflammatory disorder, wherein inflammation produces lipid metabolism disturbances, is linked to increase in cardiovascular (CV) risk with dyslipidemia. Increased reactive oxygen species and lipid peroxides have also been implicated in its pathogenesis. Aim and Objective: The aim of the study was to evaluate the status on lipid disturbances, oxidative stress, and inflammation in LP patients. Materials and Methods: The study was initiated after obtaining Institutional Ethics Committee permission and written informed consent from participants. The study included 125 patients (74 LP patients and 51 age and sex-matched controls) visiting the outpatient clinic in the dermatology department of our hospital. Variables analyzed included lipid profile, C-reactive protein (CRP), malondialdehyde (MDA), and catalase (CAT) activity. Results: Analysis of lipid parameters revealed significantly higher levels of total cholesterol (TC), triglycerides, and low-density lipoprotein cholesterol (LDL-C) along with decreased levels of high-density lipoprotein cholesterol (HDL-C) in LP patients as compared to their respective controls. LP patients also presented with a significantly higher atherogenic index that is, (TC/HDL-C) and LDL-C/HDL-C ratios than the controls. A significant increase in CRP levels was observed among the LP patients. There was a statistically significant increase in the serum levels of the lipid peroxidation product, MDA and a statistically significant decrease in CAT activity in LP patients as compared to their respective controls. A statistically significant positive correlation (r = 0.96) was observed between serum MDA levels and duration of LP whereas a significantly negative correlation (r = −0.76) was seen between CAT activity and LP duration. Conclusion: Chronic inflammation in patients with LP may explain the association with dyslipidemia and CV risk. Our findings also suggest that an increase in oxidative stress and imbalance in the antioxidant defense mechanisms in LP may play a role in the pathogenesis of LP. |
| first_indexed | 2024-12-17T13:17:34Z |
| format | Article |
| id | doaj.art-1db18091aaf5488c9904bb39905e4aee |
| institution | Directory Open Access Journal |
| issn | 0019-5154 1998-3611 |
| language | English |
| last_indexed | 2024-12-17T13:17:34Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dermatology |
| spelling | doaj.art-1db18091aaf5488c9904bb39905e4aee2022-12-21T21:46:57ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112015-01-0160543945510.4103/0019-5154.159624Alterations in lipid metabolism and antioxidant status in lichen planusFalguni H PanchalSomshukla RayRenuka P MunshiSupriya S BhaleraoChitra S NayakBackground: Lichen planus (LP), a T-cell-mediated inflammatory disorder, wherein inflammation produces lipid metabolism disturbances, is linked to increase in cardiovascular (CV) risk with dyslipidemia. Increased reactive oxygen species and lipid peroxides have also been implicated in its pathogenesis. Aim and Objective: The aim of the study was to evaluate the status on lipid disturbances, oxidative stress, and inflammation in LP patients. Materials and Methods: The study was initiated after obtaining Institutional Ethics Committee permission and written informed consent from participants. The study included 125 patients (74 LP patients and 51 age and sex-matched controls) visiting the outpatient clinic in the dermatology department of our hospital. Variables analyzed included lipid profile, C-reactive protein (CRP), malondialdehyde (MDA), and catalase (CAT) activity. Results: Analysis of lipid parameters revealed significantly higher levels of total cholesterol (TC), triglycerides, and low-density lipoprotein cholesterol (LDL-C) along with decreased levels of high-density lipoprotein cholesterol (HDL-C) in LP patients as compared to their respective controls. LP patients also presented with a significantly higher atherogenic index that is, (TC/HDL-C) and LDL-C/HDL-C ratios than the controls. A significant increase in CRP levels was observed among the LP patients. There was a statistically significant increase in the serum levels of the lipid peroxidation product, MDA and a statistically significant decrease in CAT activity in LP patients as compared to their respective controls. A statistically significant positive correlation (r = 0.96) was observed between serum MDA levels and duration of LP whereas a significantly negative correlation (r = −0.76) was seen between CAT activity and LP duration. Conclusion: Chronic inflammation in patients with LP may explain the association with dyslipidemia and CV risk. Our findings also suggest that an increase in oxidative stress and imbalance in the antioxidant defense mechanisms in LP may play a role in the pathogenesis of LP.http://www.e-ijd.org/article.asp?issn=0019-5154;year=2015;volume=60;issue=5;spage=439;epage=455;aulast=Cardiovascular riskdyslipidemiainflammationlichen planusoxidative stress |
| spellingShingle | Falguni H Panchal Somshukla Ray Renuka P Munshi Supriya S Bhalerao Chitra S Nayak Alterations in lipid metabolism and antioxidant status in lichen planus Indian Journal of Dermatology Cardiovascular risk dyslipidemia inflammation lichen planus oxidative stress |
| title | Alterations in lipid metabolism and antioxidant status in lichen planus |
| title_full | Alterations in lipid metabolism and antioxidant status in lichen planus |
| title_fullStr | Alterations in lipid metabolism and antioxidant status in lichen planus |
| title_full_unstemmed | Alterations in lipid metabolism and antioxidant status in lichen planus |
| title_short | Alterations in lipid metabolism and antioxidant status in lichen planus |
| title_sort | alterations in lipid metabolism and antioxidant status in lichen planus |
| topic | Cardiovascular risk dyslipidemia inflammation lichen planus oxidative stress |
| url | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2015;volume=60;issue=5;spage=439;epage=455;aulast= |
| work_keys_str_mv | AT falgunihpanchal alterationsinlipidmetabolismandantioxidantstatusinlichenplanus AT somshuklaray alterationsinlipidmetabolismandantioxidantstatusinlichenplanus AT renukapmunshi alterationsinlipidmetabolismandantioxidantstatusinlichenplanus AT supriyasbhalerao alterationsinlipidmetabolismandantioxidantstatusinlichenplanus AT chitrasnayak alterationsinlipidmetabolismandantioxidantstatusinlichenplanus |