Post-COVID-19 Sydrome and Decrease in Health-Related Quality of Life in Kidney Transplant Recipients after SARS-COV-2 Infection—A Cohort Longitudinal Study from the North of Poland
Introduction: Patients after SARS-CoV-2 infection frequently face “Post-COVID-19 Syndrome”, defined by symptoms that develop during or after COVID-19, continue for more than 12 weeks, and are not explained by an alternative diagnosis. We aimed to evaluate the presence of post-COVID-19 syndrome and i...
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MDPI AG
2021-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/21/5205 |
| _version_ | 1797512199315390464 |
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| author | Agnieszka Malinowska Marta Muchlado Zuzanna Ślizień Bogdan Biedunkiewicz Zbigniew Heleniak Alicja Dębska-Ślizień Leszek Tylicki |
| author_facet | Agnieszka Malinowska Marta Muchlado Zuzanna Ślizień Bogdan Biedunkiewicz Zbigniew Heleniak Alicja Dębska-Ślizień Leszek Tylicki |
| author_sort | Agnieszka Malinowska |
| collection | DOAJ |
| description | Introduction: Patients after SARS-CoV-2 infection frequently face “Post-COVID-19 Syndrome”, defined by symptoms that develop during or after COVID-19, continue for more than 12 weeks, and are not explained by an alternative diagnosis. We aimed to evaluate the presence of post-COVID-19 syndrome and its predictors in kidney transplant recipients (KTR) 6 months after the disease. Materials and Methods: A total of 67 KTR (38 m) with a mean age of 53.6 ± 14 years, 7.3 ± 6.4 years post-transplant were included in the cohort longitudinal study. Thirty-nine (58.2%) of them were hospitalized, but not one required invasive ventilation therapy. They were interviewed 6 months after being infected, with a series of standardized questionnaires: a self-reported symptoms questionnaire, the modified British Medical Research Council (mMRC) dyspnea scale, EQ-5D-5L questionnaire, and EQ-VAS scale. Results: Post-COVID-19 syndrome was diagnosed in 70.1% of KTR and 26.9% of them reported at least three persistent symptoms. The most common symptoms were fatigue (43.3%), hair loss (31.3%), memory impairment (11.9%), muscle aches, and headaches (11.9%). Dyspnea with an mMRC scale grade of at least 1 was reported by 34.3% patients vs. 14.9% before infection; 47.8% stated that they still feel worse than before the disease. Mean EQ-VAS scores were 64.83 vs. 73.34 before infection. The persistent symptoms are more frequent in older patients and those with greater comorbidity. Conclusions: Persistent symptoms of post-COVID-19 syndrome are present in the majority of KTR, which highlights the need for long-term follow-up as well as diagnostic and rehabilitation programs. |
| first_indexed | 2024-03-10T05:58:29Z |
| format | Article |
| id | doaj.art-1db1a4b9a2b043748a08020917131ffb |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T05:58:29Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-1db1a4b9a2b043748a08020917131ffb2023-11-22T21:08:54ZengMDPI AGJournal of Clinical Medicine2077-03832021-11-011021520510.3390/jcm10215205Post-COVID-19 Sydrome and Decrease in Health-Related Quality of Life in Kidney Transplant Recipients after SARS-COV-2 Infection—A Cohort Longitudinal Study from the North of PolandAgnieszka Malinowska0Marta Muchlado1Zuzanna Ślizień2Bogdan Biedunkiewicz3Zbigniew Heleniak4Alicja Dębska-Ślizień5Leszek Tylicki6Department of Nephrology Transplantology and Internal Medicine, Medical University of Gdańsk, 80-210 Gdańsk, PolandDepartment of Nephrology Transplantology and Internal Medicine, Medical University of Gdańsk, 80-210 Gdańsk, PolandDepartment of Nephrology Transplantology and Internal Medicine, Medical University of Gdańsk, 80-210 Gdańsk, PolandDepartment of Nephrology Transplantology and Internal Medicine, Medical University of Gdańsk, 80-210 Gdańsk, PolandDepartment of Nephrology Transplantology and Internal Medicine, Medical University of Gdańsk, 80-210 Gdańsk, PolandDepartment of Nephrology Transplantology and Internal Medicine, Medical University of Gdańsk, 80-210 Gdańsk, PolandDepartment of Nephrology Transplantology and Internal Medicine, Medical University of Gdańsk, 80-210 Gdańsk, PolandIntroduction: Patients after SARS-CoV-2 infection frequently face “Post-COVID-19 Syndrome”, defined by symptoms that develop during or after COVID-19, continue for more than 12 weeks, and are not explained by an alternative diagnosis. We aimed to evaluate the presence of post-COVID-19 syndrome and its predictors in kidney transplant recipients (KTR) 6 months after the disease. Materials and Methods: A total of 67 KTR (38 m) with a mean age of 53.6 ± 14 years, 7.3 ± 6.4 years post-transplant were included in the cohort longitudinal study. Thirty-nine (58.2%) of them were hospitalized, but not one required invasive ventilation therapy. They were interviewed 6 months after being infected, with a series of standardized questionnaires: a self-reported symptoms questionnaire, the modified British Medical Research Council (mMRC) dyspnea scale, EQ-5D-5L questionnaire, and EQ-VAS scale. Results: Post-COVID-19 syndrome was diagnosed in 70.1% of KTR and 26.9% of them reported at least three persistent symptoms. The most common symptoms were fatigue (43.3%), hair loss (31.3%), memory impairment (11.9%), muscle aches, and headaches (11.9%). Dyspnea with an mMRC scale grade of at least 1 was reported by 34.3% patients vs. 14.9% before infection; 47.8% stated that they still feel worse than before the disease. Mean EQ-VAS scores were 64.83 vs. 73.34 before infection. The persistent symptoms are more frequent in older patients and those with greater comorbidity. Conclusions: Persistent symptoms of post-COVID-19 syndrome are present in the majority of KTR, which highlights the need for long-term follow-up as well as diagnostic and rehabilitation programs.https://www.mdpi.com/2077-0383/10/21/5205COVID-19kidney transplant recipientpost-COVID-19 syndromelong COVID-19 symptoms |
| spellingShingle | Agnieszka Malinowska Marta Muchlado Zuzanna Ślizień Bogdan Biedunkiewicz Zbigniew Heleniak Alicja Dębska-Ślizień Leszek Tylicki Post-COVID-19 Sydrome and Decrease in Health-Related Quality of Life in Kidney Transplant Recipients after SARS-COV-2 Infection—A Cohort Longitudinal Study from the North of Poland Journal of Clinical Medicine COVID-19 kidney transplant recipient post-COVID-19 syndrome long COVID-19 symptoms |
| title | Post-COVID-19 Sydrome and Decrease in Health-Related Quality of Life in Kidney Transplant Recipients after SARS-COV-2 Infection—A Cohort Longitudinal Study from the North of Poland |
| title_full | Post-COVID-19 Sydrome and Decrease in Health-Related Quality of Life in Kidney Transplant Recipients after SARS-COV-2 Infection—A Cohort Longitudinal Study from the North of Poland |
| title_fullStr | Post-COVID-19 Sydrome and Decrease in Health-Related Quality of Life in Kidney Transplant Recipients after SARS-COV-2 Infection—A Cohort Longitudinal Study from the North of Poland |
| title_full_unstemmed | Post-COVID-19 Sydrome and Decrease in Health-Related Quality of Life in Kidney Transplant Recipients after SARS-COV-2 Infection—A Cohort Longitudinal Study from the North of Poland |
| title_short | Post-COVID-19 Sydrome and Decrease in Health-Related Quality of Life in Kidney Transplant Recipients after SARS-COV-2 Infection—A Cohort Longitudinal Study from the North of Poland |
| title_sort | post covid 19 sydrome and decrease in health related quality of life in kidney transplant recipients after sars cov 2 infection a cohort longitudinal study from the north of poland |
| topic | COVID-19 kidney transplant recipient post-COVID-19 syndrome long COVID-19 symptoms |
| url | https://www.mdpi.com/2077-0383/10/21/5205 |
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