Inhibitory Effectiveness in Delayed-Rectifier Potassium Current Caused by Vortioxetine, Known to Be a Novel Antidepressant

Inhibitory Effectiveness in Delayed-Rectifier Potassium Current Caused by Vortioxetine, Known to Be a Novel Antidepressant

Vortioxetine (VOR) is recognized to exert antidepressant actions. However, whether this drug modifies ionic currents in excitable cells remains unclear. The aim of this study was to explore the electrophysiological effects of VOR and other related compounds in pituitary GH<sub>3</sub> ce...

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Bibliographic Details
Main Authors:	Hung-Tsung Hsiao, Jeffrey Chi-Fei Wang, Sheng-Nan Wu
Format:	Article
Language:	English
Published:	MDPI AG 2022-06-01
Series:	Biomedicines
Subjects:	vortioxetine (1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine) voltage-gated K<sup>+</sup> current delayed-rectifier K<sup>+</sup> current <i>erg</i>-mediated K<sup>+</sup> current inactivation kinetics binding scheme
Online Access:	https://www.mdpi.com/2227-9059/10/6/1318

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