The in vitro antibacterial effect of permethrin and formaldehyde on Staphylococcus aureus
Abstract Antibiotic‐resistant strains of bacteria such as methicillin‐resistant Staphylococcus aureus are a threat to human health, and effective treatment options against them are needed. This study aimed to determine whether the insecticide permethrin was capable of inhibiting the growth of S. aur...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-08-01
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| Series: | MicrobiologyOpen |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mbo3.1054 |
| _version_ | 1818878588663889920 |
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| author | Philip Nikolic Poonam Mudgil John Whitehall |
| author_facet | Philip Nikolic Poonam Mudgil John Whitehall |
| author_sort | Philip Nikolic |
| collection | DOAJ |
| description | Abstract Antibiotic‐resistant strains of bacteria such as methicillin‐resistant Staphylococcus aureus are a threat to human health, and effective treatment options against them are needed. This study aimed to determine whether the insecticide permethrin was capable of inhibiting the growth of S. aureus or if some other component of a permethrin cream was responsible for a decrease in scabies associated bacterial infection previously observed. Ten S. aureus strains were grown in the presence of permethrin and formaldehyde both alone and in combination with percent inhibition determined by viable counts. Also, a time‐kill assay was conducted on S. aureus exposed to the same conditions. Finally, the morphology of S. aureus grown in the presence of permethrin was examined by scanning electron microscopy. Bacterial inhibition by permethrin ranged from 0% to 41% whereas inhibition by formaldehyde was 100%. The time‐kill curves of permethrin exposed cells were very similar to the positive growth control while the formaldehyde and combination exposure showed complete inhibition even at the 0‐hr time point. The scanning electron micrographs of permethrin grown S. aureus showed healthy cocci cells with no sign of cell damage. Our results show that permethrin is not capable of inhibiting the growth of bacteria enough for it to be termed bactericidal. Formaldehyde is a known antiseptic and therefore was responsible for the antibacterial effect observed after the use of permethrin cream. |
| first_indexed | 2024-12-19T14:16:34Z |
| format | Article |
| id | doaj.art-1db946632f284816951f99629729071c |
| institution | Directory Open Access Journal |
| issn | 2045-8827 |
| language | English |
| last_indexed | 2024-12-19T14:16:34Z |
| publishDate | 2020-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | MicrobiologyOpen |
| spelling | doaj.art-1db946632f284816951f99629729071c2022-12-21T20:17:58ZengWileyMicrobiologyOpen2045-88272020-08-0198n/an/a10.1002/mbo3.1054The in vitro antibacterial effect of permethrin and formaldehyde on Staphylococcus aureusPhilip Nikolic0Poonam Mudgil1John Whitehall2School of Medicine Western Sydney University Campbelltown NSW AustraliaSchool of Medicine Western Sydney University Campbelltown NSW AustraliaSchool of Medicine Western Sydney University Campbelltown NSW AustraliaAbstract Antibiotic‐resistant strains of bacteria such as methicillin‐resistant Staphylococcus aureus are a threat to human health, and effective treatment options against them are needed. This study aimed to determine whether the insecticide permethrin was capable of inhibiting the growth of S. aureus or if some other component of a permethrin cream was responsible for a decrease in scabies associated bacterial infection previously observed. Ten S. aureus strains were grown in the presence of permethrin and formaldehyde both alone and in combination with percent inhibition determined by viable counts. Also, a time‐kill assay was conducted on S. aureus exposed to the same conditions. Finally, the morphology of S. aureus grown in the presence of permethrin was examined by scanning electron microscopy. Bacterial inhibition by permethrin ranged from 0% to 41% whereas inhibition by formaldehyde was 100%. The time‐kill curves of permethrin exposed cells were very similar to the positive growth control while the formaldehyde and combination exposure showed complete inhibition even at the 0‐hr time point. The scanning electron micrographs of permethrin grown S. aureus showed healthy cocci cells with no sign of cell damage. Our results show that permethrin is not capable of inhibiting the growth of bacteria enough for it to be termed bactericidal. Formaldehyde is a known antiseptic and therefore was responsible for the antibacterial effect observed after the use of permethrin cream.https://doi.org/10.1002/mbo3.1054antibacterial activityformaldehydemethicillin‐resistant Staphylococcus aureuspermethrin |
| spellingShingle | Philip Nikolic Poonam Mudgil John Whitehall The in vitro antibacterial effect of permethrin and formaldehyde on Staphylococcus aureus MicrobiologyOpen antibacterial activity formaldehyde methicillin‐resistant Staphylococcus aureus permethrin |
| title | The in vitro antibacterial effect of permethrin and formaldehyde on Staphylococcus aureus |
| title_full | The in vitro antibacterial effect of permethrin and formaldehyde on Staphylococcus aureus |
| title_fullStr | The in vitro antibacterial effect of permethrin and formaldehyde on Staphylococcus aureus |
| title_full_unstemmed | The in vitro antibacterial effect of permethrin and formaldehyde on Staphylococcus aureus |
| title_short | The in vitro antibacterial effect of permethrin and formaldehyde on Staphylococcus aureus |
| title_sort | in vitro antibacterial effect of permethrin and formaldehyde on staphylococcus aureus |
| topic | antibacterial activity formaldehyde methicillin‐resistant Staphylococcus aureus permethrin |
| url | https://doi.org/10.1002/mbo3.1054 |
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