Baicalein Prevents 6-Hydroxydopamine-Induced Dopaminergic Dysfunction and Lipid Peroxidation in Mice
The effects of baicalein on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity were evaluated. Intracerebroventricularly (i.c.v.) injection of 6-OHDA was done to young mice. Baicalein was administered intraperitoneally 30 min before and 90 min after i.c.v. injection. Animals received further injection...
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| Format: | Article |
| Language: | English |
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Elsevier
2005-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S134786131932198X |
| _version_ | 1819129490849136640 |
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| author | Heh-In Im Wan Seok Joo Eunjoo Nam Eun-sun Lee Yu-jin Hwang Yong Sik Kim |
| author_facet | Heh-In Im Wan Seok Joo Eunjoo Nam Eun-sun Lee Yu-jin Hwang Yong Sik Kim |
| author_sort | Heh-In Im |
| collection | DOAJ |
| description | The effects of baicalein on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity were evaluated. Intracerebroventricularly (i.c.v.) injection of 6-OHDA was done to young mice. Baicalein was administered intraperitoneally 30 min before and 90 min after i.c.v. injection. Animals received further injection of bacalein daily for 3 consecutive days. Rotarod performance was assessed, tyrosine hydroxylase (TH) Western blotting was performed, and dopamine (DA) levels and peroxidation were determined. High dose of baicalein effectively improved rotarod performance and prevented the reduction of striatal DA levels and TH contents in the striatum and subtantia nigra (SN). In addition, lipid peroxidation level was decreased by baicalein at 3 and 7 days after 6-OHDA injection. These results showed that baicalein effectively prevents the 6-OHDA-induced dopaminergic dysfunction through an antioxidative action. Keywords:: 6-hydroxydopamine, baicalein, tyrosine hydroxylase |
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| format | Article |
| id | doaj.art-1db9beb4a60d4479a8a8ddb4dc3c1e86 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-22T08:44:33Z |
| publishDate | 2005-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-1db9beb4a60d4479a8a8ddb4dc3c1e862022-12-21T18:32:09ZengElsevierJournal of Pharmacological Sciences1347-86132005-01-01982185189Baicalein Prevents 6-Hydroxydopamine-Induced Dopaminergic Dysfunction and Lipid Peroxidation in MiceHeh-In Im0Wan Seok Joo1Eunjoo Nam2Eun-sun Lee3Yu-jin Hwang4Yong Sik Kim5Department of Pharmacology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-799, KoreaDivision of Biologics Evaluation, Korea Food and Drug Administration, Seoul 122-704, KoreaDepartment of Pharmacology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-799, KoreaDepartment of Pharmacology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-799, KoreaDepartment of Pharmacology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-799, KoreaDepartment of Pharmacology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-799, Korea; Corresponding author. FAX: +82-2-745-7996 E-mail: kimysu@plaza.snu.ac.krThe effects of baicalein on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity were evaluated. Intracerebroventricularly (i.c.v.) injection of 6-OHDA was done to young mice. Baicalein was administered intraperitoneally 30 min before and 90 min after i.c.v. injection. Animals received further injection of bacalein daily for 3 consecutive days. Rotarod performance was assessed, tyrosine hydroxylase (TH) Western blotting was performed, and dopamine (DA) levels and peroxidation were determined. High dose of baicalein effectively improved rotarod performance and prevented the reduction of striatal DA levels and TH contents in the striatum and subtantia nigra (SN). In addition, lipid peroxidation level was decreased by baicalein at 3 and 7 days after 6-OHDA injection. These results showed that baicalein effectively prevents the 6-OHDA-induced dopaminergic dysfunction through an antioxidative action. Keywords:: 6-hydroxydopamine, baicalein, tyrosine hydroxylasehttp://www.sciencedirect.com/science/article/pii/S134786131932198X |
| spellingShingle | Heh-In Im Wan Seok Joo Eunjoo Nam Eun-sun Lee Yu-jin Hwang Yong Sik Kim Baicalein Prevents 6-Hydroxydopamine-Induced Dopaminergic Dysfunction and Lipid Peroxidation in Mice Journal of Pharmacological Sciences |
| title | Baicalein Prevents 6-Hydroxydopamine-Induced Dopaminergic Dysfunction and Lipid Peroxidation in Mice |
| title_full | Baicalein Prevents 6-Hydroxydopamine-Induced Dopaminergic Dysfunction and Lipid Peroxidation in Mice |
| title_fullStr | Baicalein Prevents 6-Hydroxydopamine-Induced Dopaminergic Dysfunction and Lipid Peroxidation in Mice |
| title_full_unstemmed | Baicalein Prevents 6-Hydroxydopamine-Induced Dopaminergic Dysfunction and Lipid Peroxidation in Mice |
| title_short | Baicalein Prevents 6-Hydroxydopamine-Induced Dopaminergic Dysfunction and Lipid Peroxidation in Mice |
| title_sort | baicalein prevents 6 hydroxydopamine induced dopaminergic dysfunction and lipid peroxidation in mice |
| url | http://www.sciencedirect.com/science/article/pii/S134786131932198X |
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