Biomedical Activity of Chitin/Chitosan Based Materials—Influence of Physicochemical Properties Apart from Molecular Weight and Degree of N-Acetylation
The physicochemical nature of chitin and chitosan, which influences the biomedical activity of these compounds, is strongly related to the source of chitin and the conditions of the chitin/chitosan production process. Apart from widely described key factors such as weight-averaged molecular weight (...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-11-01
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| Series: | Polymers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2073-4360/3/4/1875/ |
| _version_ | 1811270841081528320 |
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| author | Mirko X. Weinhold Piotr Stepnowski Jorg Thöming Jolanta Kumirska |
| author_facet | Mirko X. Weinhold Piotr Stepnowski Jorg Thöming Jolanta Kumirska |
| author_sort | Mirko X. Weinhold |
| collection | DOAJ |
| description | The physicochemical nature of chitin and chitosan, which influences the biomedical activity of these compounds, is strongly related to the source of chitin and the conditions of the chitin/chitosan production process. Apart from widely described key factors such as weight-averaged molecular weight (MW) and degree of N-acetylation (DA), other physicochemical parameters like polydispersity (MW/MN), crystallinity or the pattern of acetylation (PA) have to be taken into consideration. From the biological point of view, these parameters affect a very important factor—the solubility of chitin and chitosan in water and organic solvents. The physicochemical properties of chitosan solutions can be controlled by manipulating solution conditions (temperature, pH, ionic strength, concentration, solvent). The degree of substitution of the hydroxyl and the amino groups or the degree of quaternization of the amino groups also influence the mechanical and biological properties of chitosan samples. Finally, a considerable research effort has been directed towards developing safe and efficient chitin/chitosan-based products because many factors, like the size of nanoparticles, can determine the biomedical characteristics of medicinal products. The influence of these factors on the biomedical activity of chitin/chitosan-based products is presented in this report in more detail. |
| first_indexed | 2024-04-12T22:09:31Z |
| format | Article |
| id | doaj.art-1dbbddf1ae7c4c019ebeee9e2966c7c3 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-04-12T22:09:31Z |
| publishDate | 2011-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-1dbbddf1ae7c4c019ebeee9e2966c7c32022-12-22T03:14:48ZengMDPI AGPolymers2073-43602011-11-01341875190110.3390/polym3041875Biomedical Activity of Chitin/Chitosan Based Materials—Influence of Physicochemical Properties Apart from Molecular Weight and Degree of N-AcetylationMirko X. WeinholdPiotr StepnowskiJorg ThömingJolanta KumirskaThe physicochemical nature of chitin and chitosan, which influences the biomedical activity of these compounds, is strongly related to the source of chitin and the conditions of the chitin/chitosan production process. Apart from widely described key factors such as weight-averaged molecular weight (MW) and degree of N-acetylation (DA), other physicochemical parameters like polydispersity (MW/MN), crystallinity or the pattern of acetylation (PA) have to be taken into consideration. From the biological point of view, these parameters affect a very important factor—the solubility of chitin and chitosan in water and organic solvents. The physicochemical properties of chitosan solutions can be controlled by manipulating solution conditions (temperature, pH, ionic strength, concentration, solvent). The degree of substitution of the hydroxyl and the amino groups or the degree of quaternization of the amino groups also influence the mechanical and biological properties of chitosan samples. Finally, a considerable research effort has been directed towards developing safe and efficient chitin/chitosan-based products because many factors, like the size of nanoparticles, can determine the biomedical characteristics of medicinal products. The influence of these factors on the biomedical activity of chitin/chitosan-based products is presented in this report in more detail.http://www.mdpi.com/2073-4360/3/4/1875/chitinchitosanbiomedical activitystructure-property-activity relationshipsionic strengthpHchitosan sourcedegree of substitutiondegree of quaternization |
| spellingShingle | Mirko X. Weinhold Piotr Stepnowski Jorg Thöming Jolanta Kumirska Biomedical Activity of Chitin/Chitosan Based Materials—Influence of Physicochemical Properties Apart from Molecular Weight and Degree of N-Acetylation Polymers chitin chitosan biomedical activity structure-property-activity relationships ionic strength pH chitosan source degree of substitution degree of quaternization |
| title | Biomedical Activity of Chitin/Chitosan Based Materials—Influence of Physicochemical Properties Apart from Molecular Weight and Degree of N-Acetylation |
| title_full | Biomedical Activity of Chitin/Chitosan Based Materials—Influence of Physicochemical Properties Apart from Molecular Weight and Degree of N-Acetylation |
| title_fullStr | Biomedical Activity of Chitin/Chitosan Based Materials—Influence of Physicochemical Properties Apart from Molecular Weight and Degree of N-Acetylation |
| title_full_unstemmed | Biomedical Activity of Chitin/Chitosan Based Materials—Influence of Physicochemical Properties Apart from Molecular Weight and Degree of N-Acetylation |
| title_short | Biomedical Activity of Chitin/Chitosan Based Materials—Influence of Physicochemical Properties Apart from Molecular Weight and Degree of N-Acetylation |
| title_sort | biomedical activity of chitin chitosan based materials influence of physicochemical properties apart from molecular weight and degree of n acetylation |
| topic | chitin chitosan biomedical activity structure-property-activity relationships ionic strength pH chitosan source degree of substitution degree of quaternization |
| url | http://www.mdpi.com/2073-4360/3/4/1875/ |
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