Is Botulinum Toxin Effective in Treating Orofacial Neuropathic Pain Disorders? A Systematic Review
Background: The aim of this paper is to provide a systematic review of the literature regarding the clinical use of botulinum toxin (BTX) to treat various orofacial neuropathic pain disorders (NP). Methods: A comprehensive literature search was conducted using Medline, Web of Science, and the Cochra...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/15/9/541 |
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| author | Matteo Val Robert Delcanho Marco Ferrari Luca Guarda Nardini Daniele Manfredini |
| author_facet | Matteo Val Robert Delcanho Marco Ferrari Luca Guarda Nardini Daniele Manfredini |
| author_sort | Matteo Val |
| collection | DOAJ |
| description | Background: The aim of this paper is to provide a systematic review of the literature regarding the clinical use of botulinum toxin (BTX) to treat various orofacial neuropathic pain disorders (NP). Methods: A comprehensive literature search was conducted using Medline, Web of Science, and the Cochrane Library databases. Only randomized clinical trials (RCT) published between 2003 and the end of June 2023, investigating the use of BTX to treat NP, were selected. PICO guidelines were used to select and tabulate the articles. Results: A total of 6 RCTs were selected. Five articles used BTX injections to treat classical trigeminal neuralgia, and one to treat post-herpetic neuralgia. A total of 795 patients received BTX injections. The selected studies utilised different doses and methods of injections and doses. All the selected studies concluded superiority of BTX injections over placebo for reducing pain levels, and 5 out 6 of them highlighted an improvement in the patient’s quality of life. Most of the studies reported transient and mild side effects. Conclusion: There is evidence of the efficacy of BTX injections in orofacial pain management. However, improved study protocols are required to provide direction for the clinical use of BTX to treat various orofacial neuropathic pain disorders. |
| first_indexed | 2024-03-10T21:53:19Z |
| format | Article |
| id | doaj.art-1dbbfa5ea17c4b7eabfc533c24597eeb |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-10T21:53:19Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-1dbbfa5ea17c4b7eabfc533c24597eeb2023-11-19T13:15:47ZengMDPI AGToxins2072-66512023-09-0115954110.3390/toxins15090541Is Botulinum Toxin Effective in Treating Orofacial Neuropathic Pain Disorders? A Systematic ReviewMatteo Val0Robert Delcanho1Marco Ferrari2Luca Guarda Nardini3Daniele Manfredini4Department of Biomedical Technologies, School of Dental Medicine, University of Siena, 53100 Siena, ItalySchool of Dentistry, University of Western Australia, Perth 6009, AustraliaDepartment of Biomedical Technologies, School of Dental Medicine, University of Siena, 53100 Siena, ItalyUnit of Oral and Maxillofacial Surgery, Ca’Foncello Hospital, 31100 Treviso, ItalyDepartment of Biomedical Technologies, School of Dental Medicine, University of Siena, 53100 Siena, ItalyBackground: The aim of this paper is to provide a systematic review of the literature regarding the clinical use of botulinum toxin (BTX) to treat various orofacial neuropathic pain disorders (NP). Methods: A comprehensive literature search was conducted using Medline, Web of Science, and the Cochrane Library databases. Only randomized clinical trials (RCT) published between 2003 and the end of June 2023, investigating the use of BTX to treat NP, were selected. PICO guidelines were used to select and tabulate the articles. Results: A total of 6 RCTs were selected. Five articles used BTX injections to treat classical trigeminal neuralgia, and one to treat post-herpetic neuralgia. A total of 795 patients received BTX injections. The selected studies utilised different doses and methods of injections and doses. All the selected studies concluded superiority of BTX injections over placebo for reducing pain levels, and 5 out 6 of them highlighted an improvement in the patient’s quality of life. Most of the studies reported transient and mild side effects. Conclusion: There is evidence of the efficacy of BTX injections in orofacial pain management. However, improved study protocols are required to provide direction for the clinical use of BTX to treat various orofacial neuropathic pain disorders.https://www.mdpi.com/2072-6651/15/9/541botulinum toxin type Aorofacial neuropathic disordersessential trigeminal neuralgiapainquality of life |
| spellingShingle | Matteo Val Robert Delcanho Marco Ferrari Luca Guarda Nardini Daniele Manfredini Is Botulinum Toxin Effective in Treating Orofacial Neuropathic Pain Disorders? A Systematic Review Toxins botulinum toxin type A orofacial neuropathic disorders essential trigeminal neuralgia pain quality of life |
| title | Is Botulinum Toxin Effective in Treating Orofacial Neuropathic Pain Disorders? A Systematic Review |
| title_full | Is Botulinum Toxin Effective in Treating Orofacial Neuropathic Pain Disorders? A Systematic Review |
| title_fullStr | Is Botulinum Toxin Effective in Treating Orofacial Neuropathic Pain Disorders? A Systematic Review |
| title_full_unstemmed | Is Botulinum Toxin Effective in Treating Orofacial Neuropathic Pain Disorders? A Systematic Review |
| title_short | Is Botulinum Toxin Effective in Treating Orofacial Neuropathic Pain Disorders? A Systematic Review |
| title_sort | is botulinum toxin effective in treating orofacial neuropathic pain disorders a systematic review |
| topic | botulinum toxin type A orofacial neuropathic disorders essential trigeminal neuralgia pain quality of life |
| url | https://www.mdpi.com/2072-6651/15/9/541 |
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