Diagnostic value of CD-10 marker in differentiating of papillary thyroid carcinoma from benign thyroid lesions
Background: Using of CD10 in accordance with clinical and histological features of thyroid lesions could be used as both diagnostic and prognostic tool, which consequently influence the management and their prognosis for survival of patients with thyroid neoplasms especially papillary thyroid carcin...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Advanced Biomedical Research |
| Subjects: | |
| Online Access: | http://www.advbiores.net/article.asp?issn=2277-9175;year=2014;volume=3;issue=1;spage=206;epage=206;aulast=Mokhtari |
| _version_ | 1818434534357598208 |
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| author | Mojgan Mokhtari Farahnaz Ameri |
| author_facet | Mojgan Mokhtari Farahnaz Ameri |
| author_sort | Mojgan Mokhtari |
| collection | DOAJ |
| description | Background: Using of CD10 in accordance with clinical and histological features of thyroid lesions could be used as both diagnostic and prognostic tool, which consequently influence the management and their prognosis for survival of patients with thyroid neoplasms especially papillary thyroid carcinoma (PTC). The aim of this study was to determine its expression in PTC and different benign thyroid lesions.
Materials and Methods: In this descriptive-analytic, cross-sectional study, paraffin-embedded tissues of patients with definitive pathologic diagnosis of different benign thyroid lesions and PTC were retrieved. Immunostained sections of each slides was performed using immunohistochemistry methods and expression of CD10 was compared in two groups of benign thyroid lesions and PTC.
Results: From selected cases 134 sections studied in two groups of PTC (n = 67) and benign thyroid lesions (n = 67). CD10 were immunohistochemically positive in 29.9% of PTC cases, but in none of the thyroid benign lesions (0%) (P < 0.001). There was not significant relationship between expression of CD10 with age and sex of the studied population (P > 0.05).
Conclusion: The results of the current study indicate that due to the higher expression of CD10 in PTC than benign thyroid lesions it might be used for differentiating mentioned lesions. But for using it as a diagnostic tool further studies with larger sample size and determination of its sensitivity, specificity and cut-off point is necessary. |
| first_indexed | 2024-12-14T16:38:31Z |
| format | Article |
| id | doaj.art-1dbfd54212b44e9cbb24c621b6b84ca4 |
| institution | Directory Open Access Journal |
| issn | 2277-9175 2277-9175 |
| language | English |
| last_indexed | 2024-12-14T16:38:31Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Advanced Biomedical Research |
| spelling | doaj.art-1dbfd54212b44e9cbb24c621b6b84ca42022-12-21T22:54:22ZengWolters Kluwer Medknow PublicationsAdvanced Biomedical Research2277-91752277-91752014-01-013120620610.4103/2277-9175.143241Diagnostic value of CD-10 marker in differentiating of papillary thyroid carcinoma from benign thyroid lesionsMojgan MokhtariFarahnaz AmeriBackground: Using of CD10 in accordance with clinical and histological features of thyroid lesions could be used as both diagnostic and prognostic tool, which consequently influence the management and their prognosis for survival of patients with thyroid neoplasms especially papillary thyroid carcinoma (PTC). The aim of this study was to determine its expression in PTC and different benign thyroid lesions. Materials and Methods: In this descriptive-analytic, cross-sectional study, paraffin-embedded tissues of patients with definitive pathologic diagnosis of different benign thyroid lesions and PTC were retrieved. Immunostained sections of each slides was performed using immunohistochemistry methods and expression of CD10 was compared in two groups of benign thyroid lesions and PTC. Results: From selected cases 134 sections studied in two groups of PTC (n = 67) and benign thyroid lesions (n = 67). CD10 were immunohistochemically positive in 29.9% of PTC cases, but in none of the thyroid benign lesions (0%) (P < 0.001). There was not significant relationship between expression of CD10 with age and sex of the studied population (P > 0.05). Conclusion: The results of the current study indicate that due to the higher expression of CD10 in PTC than benign thyroid lesions it might be used for differentiating mentioned lesions. But for using it as a diagnostic tool further studies with larger sample size and determination of its sensitivity, specificity and cut-off point is necessary.http://www.advbiores.net/article.asp?issn=2277-9175;year=2014;volume=3;issue=1;spage=206;epage=206;aulast=MokhtariCD10immunohistochemistrypapillary thyroid carcinoma |
| spellingShingle | Mojgan Mokhtari Farahnaz Ameri Diagnostic value of CD-10 marker in differentiating of papillary thyroid carcinoma from benign thyroid lesions Advanced Biomedical Research CD10 immunohistochemistry papillary thyroid carcinoma |
| title | Diagnostic value of CD-10 marker in differentiating of papillary thyroid carcinoma from benign thyroid lesions |
| title_full | Diagnostic value of CD-10 marker in differentiating of papillary thyroid carcinoma from benign thyroid lesions |
| title_fullStr | Diagnostic value of CD-10 marker in differentiating of papillary thyroid carcinoma from benign thyroid lesions |
| title_full_unstemmed | Diagnostic value of CD-10 marker in differentiating of papillary thyroid carcinoma from benign thyroid lesions |
| title_short | Diagnostic value of CD-10 marker in differentiating of papillary thyroid carcinoma from benign thyroid lesions |
| title_sort | diagnostic value of cd 10 marker in differentiating of papillary thyroid carcinoma from benign thyroid lesions |
| topic | CD10 immunohistochemistry papillary thyroid carcinoma |
| url | http://www.advbiores.net/article.asp?issn=2277-9175;year=2014;volume=3;issue=1;spage=206;epage=206;aulast=Mokhtari |
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