Differential chemoreactome analysis of glucosamine sulfate and non-steroidal anti-inflammatory drugs: promising synergistic drug combinations
Glucosamine sulfate (GS) is essential for the regeneration of cartilaginous tissue and, in addition, it has anti-inflammatory properties comparable to those of nonsteroidal anti-inflammatory drugs (NSAIDs). Clinical trials indicate the synergism between GS and NSAIDs in osteoarthritis (OA) and other...
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2018-06-01
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| Series: | Современная ревматология |
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| Online Access: | https://mrj.ima-press.net/mrj/article/view/823 |
| _version_ | 1797876728499011584 |
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| author | O. A. Gromova I. Yu. Torshin A. M. Lila A. V. Naumov I. A. Reier A. E. Karateev |
| author_facet | O. A. Gromova I. Yu. Torshin A. M. Lila A. V. Naumov I. A. Reier A. E. Karateev |
| author_sort | O. A. Gromova |
| collection | DOAJ |
| description | Glucosamine sulfate (GS) is essential for the regeneration of cartilaginous tissue and, in addition, it has anti-inflammatory properties comparable to those of nonsteroidal anti-inflammatory drugs (NSAIDs). Clinical trials indicate the synergism between GS and NSAIDs in osteoarthritis (OA) and other joint diseases.Objective: to estimate the degree of synergism between different combinations of GS and NSAIDs.Material and methods. A differential chemoreactome analysis was employed to evaluate the effects of GS and seven agents from the class of NSAIDs, such as ketorolac, nimesulide, diclofenac, meloxicam, dexketoprofen, celecoxib, and etoricoxib, for estimating the degree of synergism between different combinations of GS and NSAIDs.Results and discussion. Dexketoprofen is shown to enhance most effectively the anti-inflammatory properties of GS as compared to ketorolac that does this to a lesser extent. The drug should be practically used as follows: the most effective combination (GS + dexketoprofen (or GS + ketorolak) is taken at week 1 of treatment for rapid pain elimination; thereafter there may be a combination of GS and NSAIDs, the intake of which is associated with minimal adverse reactions for a longer time.Conclusion. The investigation has shown that the coadministration of GS and NSAIDs is promising in treating joint diseases. |
| first_indexed | 2024-04-10T02:06:04Z |
| format | Article |
| id | doaj.art-1dc0a728c1a74eb69759f4bb8607926f |
| institution | Directory Open Access Journal |
| issn | 1996-7012 2310-158X |
| language | Russian |
| last_indexed | 2024-04-10T02:06:04Z |
| publishDate | 2018-06-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj.art-1dc0a728c1a74eb69759f4bb8607926f2023-03-13T08:39:26ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2018-06-01122364310.14412/1996-7012-2018-2-36-432090Differential chemoreactome analysis of glucosamine sulfate and non-steroidal anti-inflammatory drugs: promising synergistic drug combinationsO. A. Gromova0I. Yu. Torshin1A. M. Lila2A. V. Naumov3I. A. Reier4A. E. Karateev5Институт фармакоинформатики ФИЦ «Информатика и управление», РАНИнститут фармакоинформатики ФИЦ «Информатика и управление», РАНФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»Российский геронтологический научно-клинический центрИнститут фармакоинформатики ФИЦ «Информатика и управление», РАНФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»Glucosamine sulfate (GS) is essential for the regeneration of cartilaginous tissue and, in addition, it has anti-inflammatory properties comparable to those of nonsteroidal anti-inflammatory drugs (NSAIDs). Clinical trials indicate the synergism between GS and NSAIDs in osteoarthritis (OA) and other joint diseases.Objective: to estimate the degree of synergism between different combinations of GS and NSAIDs.Material and methods. A differential chemoreactome analysis was employed to evaluate the effects of GS and seven agents from the class of NSAIDs, such as ketorolac, nimesulide, diclofenac, meloxicam, dexketoprofen, celecoxib, and etoricoxib, for estimating the degree of synergism between different combinations of GS and NSAIDs.Results and discussion. Dexketoprofen is shown to enhance most effectively the anti-inflammatory properties of GS as compared to ketorolac that does this to a lesser extent. The drug should be practically used as follows: the most effective combination (GS + dexketoprofen (or GS + ketorolak) is taken at week 1 of treatment for rapid pain elimination; thereafter there may be a combination of GS and NSAIDs, the intake of which is associated with minimal adverse reactions for a longer time.Conclusion. The investigation has shown that the coadministration of GS and NSAIDs is promising in treating joint diseases.https://mrj.ima-press.net/mrj/article/view/823глюкозамина сульфатсустагард артрокеторолакнимесулиддекскетопрофенмелоксикамдиклофенакцелекоксибэторикоксибинтеллектуальный анализ данных |
| spellingShingle | O. A. Gromova I. Yu. Torshin A. M. Lila A. V. Naumov I. A. Reier A. E. Karateev Differential chemoreactome analysis of glucosamine sulfate and non-steroidal anti-inflammatory drugs: promising synergistic drug combinations Современная ревматология глюкозамина сульфат сустагард артро кеторолак нимесулид декскетопрофен мелоксикам диклофенак целекоксиб эторикоксиб интеллектуальный анализ данных |
| title | Differential chemoreactome analysis of glucosamine sulfate and non-steroidal anti-inflammatory drugs: promising synergistic drug combinations |
| title_full | Differential chemoreactome analysis of glucosamine sulfate and non-steroidal anti-inflammatory drugs: promising synergistic drug combinations |
| title_fullStr | Differential chemoreactome analysis of glucosamine sulfate and non-steroidal anti-inflammatory drugs: promising synergistic drug combinations |
| title_full_unstemmed | Differential chemoreactome analysis of glucosamine sulfate and non-steroidal anti-inflammatory drugs: promising synergistic drug combinations |
| title_short | Differential chemoreactome analysis of glucosamine sulfate and non-steroidal anti-inflammatory drugs: promising synergistic drug combinations |
| title_sort | differential chemoreactome analysis of glucosamine sulfate and non steroidal anti inflammatory drugs promising synergistic drug combinations |
| topic | глюкозамина сульфат сустагард артро кеторолак нимесулид декскетопрофен мелоксикам диклофенак целекоксиб эторикоксиб интеллектуальный анализ данных |
| url | https://mrj.ima-press.net/mrj/article/view/823 |
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