GDF-15 Suppresses Puromycin Aminonucleoside-Induced Podocyte Injury by Reducing Endoplasmic Reticulum Stress and Glomerular Inflammation

GDF-15 Suppresses Puromycin Aminonucleoside-Induced Podocyte Injury by Reducing Endoplasmic Reticulum Stress and Glomerular Inflammation

GDF15, also known as MIC1, is a member of the TGF-beta superfamily. Previous studies reported elevated serum levels of GDF15 in patients with kidney disorder, and its association with kidney disease progression, while other studies identified GDF15 to have protective effects. To investigate the pote...

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Bibliographic Details
Main Authors: Ekaterina von Rauchhaupt, Martin Klaus, Andrea Ribeiro, Mohsen Honarpisheh, Chenyu Li, Min Liu, Paulina Köhler, Karina Adamowicz, Christoph Schmaderer, Maja Lindenmeyer, Stefanie Steiger, Hans-Joachim Anders, Maciej Lech
Format: Article
Language:English
Published: MDPI AG 2024-04-01
Series:Cells
Subjects:
GDF15
podocytes
endoplasmic reticulum stress
podocytopathies
glomerular inflammation
Online Access:https://www.mdpi.com/2073-4409/13/7/637

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