Glomerular filtration rate in patients with type 2 diabetes mellitus: is serum isthmin-1 level a possible link?
Introduction Isthmin-1 (Ism-1) is a novel adipokine. However, little is known regarding the association between Ism-1 and type 2 diabetes mellitus (T2DM). This study aimed to investigate the relationship between serum Ism-1 levels and glomerular filtration rate (GFR) in patients with T2DM.Research d...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-08-01
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| Series: | BMJ Open Diabetes Research & Care |
| Online Access: | https://drc.bmj.com/content/11/4/e003402.full |
| _version_ | 1797729957968871424 |
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| author | Chuan Wang Lei Zhang Jinbo Liu Mingyue Xu Ruiying Feng Xiaofei Yin Ruoqi Feng |
| author_facet | Chuan Wang Lei Zhang Jinbo Liu Mingyue Xu Ruiying Feng Xiaofei Yin Ruoqi Feng |
| author_sort | Chuan Wang |
| collection | DOAJ |
| description | Introduction Isthmin-1 (Ism-1) is a novel adipokine. However, little is known regarding the association between Ism-1 and type 2 diabetes mellitus (T2DM). This study aimed to investigate the relationship between serum Ism-1 levels and glomerular filtration rate (GFR) in patients with T2DM.Research design and methods A total of 209 patients with T2DM were recruited into this retrospective study. Clinical data were collected. Fasting blood samples were collected for serum Ism-1 testing using ELISA kits. Based on the estimated glomerular filtration rate (eGFR), participants were divided into the normal eGFR group (n=167) and the decreased eGFR group (n=42). The relationship between Ism-1 and eGFR was assessed using linear and binary logistic regression analyses. Receiver operating characteristic (ROC) curve analysis was employed to examine the predictive efficacy of Ism-1 for distinguishing patients with eGFR <60 mL/min/1.73 m2.Results Compared with patients with normal eGFR, serum Ism-1 levels were increased in patients with decreased eGFR (p<0.001). Serum Ism-1 levels were negatively correlated with eGFR in patients with T2DM even after multiple adjustments (p<0.001). For each 0.1 ng/mL increment of Ism-1, the odds of having an eGFR <60 mL/min/1.73 m2 increased by 54.5% (OR=1.545; p<0.001) in patients with T2DM. ROC analysis showed that higher serum Ism-1 levels (>1.297 ng/mL) had predictive efficacy in patients with eGFR <60 mL/min/1.73 m2, with an area under the curve of 0.908.Conclusions Serum Ism-1 levels were inversely associated with eGFR, and high Ism-1 levels may be used as a potential biomarker for predicting kidney function impairment in patients with T2DM. |
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| id | doaj.art-1dc303ce10c04e1999aa81862dfde42a |
| institution | Directory Open Access Journal |
| issn | 2052-4897 |
| language | English |
| last_indexed | 2024-03-12T11:37:07Z |
| publishDate | 2023-08-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Diabetes Research & Care |
| spelling | doaj.art-1dc303ce10c04e1999aa81862dfde42a2023-09-01T03:15:08ZengBMJ Publishing GroupBMJ Open Diabetes Research & Care2052-48972023-08-0111410.1136/bmjdrc-2023-003402Glomerular filtration rate in patients with type 2 diabetes mellitus: is serum isthmin-1 level a possible link?Chuan Wang0Lei Zhang1Jinbo Liu2Mingyue Xu3Ruiying Feng4Xiaofei Yin5Ruoqi Feng6Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, 250012, Shandong Province, P.R. ChinaShandong Provincial Institute for Endemic Disease Control, Jinan, 250014, Shandong Province, P.R. ChinaDepartment of Endocrinology, Qilu Hospital, Cheeloo college of medicine, Shandong University, Jinan, 250012, P.R. ChinaInstitute of Endocrine and Metabolic Diseases of Shandong University, Jinan, 250012, Shandong Province, P.R. ChinaDepartment of Endocrinology, Qilu Hospital, Cheeloo college of medicine, Shandong University, Jinan, 250012, P.R. ChinaDepartment of Endocrinology, Qilu Hospital, Cheeloo college of medicine, Shandong University, Jinan, 250012, P.R. ChinaDepartment of Endocrinology, Qilu Hospital, Cheeloo college of medicine, Shandong University, Jinan, 250012, P.R. ChinaIntroduction Isthmin-1 (Ism-1) is a novel adipokine. However, little is known regarding the association between Ism-1 and type 2 diabetes mellitus (T2DM). This study aimed to investigate the relationship between serum Ism-1 levels and glomerular filtration rate (GFR) in patients with T2DM.Research design and methods A total of 209 patients with T2DM were recruited into this retrospective study. Clinical data were collected. Fasting blood samples were collected for serum Ism-1 testing using ELISA kits. Based on the estimated glomerular filtration rate (eGFR), participants were divided into the normal eGFR group (n=167) and the decreased eGFR group (n=42). The relationship between Ism-1 and eGFR was assessed using linear and binary logistic regression analyses. Receiver operating characteristic (ROC) curve analysis was employed to examine the predictive efficacy of Ism-1 for distinguishing patients with eGFR <60 mL/min/1.73 m2.Results Compared with patients with normal eGFR, serum Ism-1 levels were increased in patients with decreased eGFR (p<0.001). Serum Ism-1 levels were negatively correlated with eGFR in patients with T2DM even after multiple adjustments (p<0.001). For each 0.1 ng/mL increment of Ism-1, the odds of having an eGFR <60 mL/min/1.73 m2 increased by 54.5% (OR=1.545; p<0.001) in patients with T2DM. ROC analysis showed that higher serum Ism-1 levels (>1.297 ng/mL) had predictive efficacy in patients with eGFR <60 mL/min/1.73 m2, with an area under the curve of 0.908.Conclusions Serum Ism-1 levels were inversely associated with eGFR, and high Ism-1 levels may be used as a potential biomarker for predicting kidney function impairment in patients with T2DM.https://drc.bmj.com/content/11/4/e003402.full |
| spellingShingle | Chuan Wang Lei Zhang Jinbo Liu Mingyue Xu Ruiying Feng Xiaofei Yin Ruoqi Feng Glomerular filtration rate in patients with type 2 diabetes mellitus: is serum isthmin-1 level a possible link? BMJ Open Diabetes Research & Care |
| title | Glomerular filtration rate in patients with type 2 diabetes mellitus: is serum isthmin-1 level a possible link? |
| title_full | Glomerular filtration rate in patients with type 2 diabetes mellitus: is serum isthmin-1 level a possible link? |
| title_fullStr | Glomerular filtration rate in patients with type 2 diabetes mellitus: is serum isthmin-1 level a possible link? |
| title_full_unstemmed | Glomerular filtration rate in patients with type 2 diabetes mellitus: is serum isthmin-1 level a possible link? |
| title_short | Glomerular filtration rate in patients with type 2 diabetes mellitus: is serum isthmin-1 level a possible link? |
| title_sort | glomerular filtration rate in patients with type 2 diabetes mellitus is serum isthmin 1 level a possible link |
| url | https://drc.bmj.com/content/11/4/e003402.full |
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