Comparative genomics of the family <it>Vibrionaceae </it>reveals the wide distribution of genes encoding virulence-associated proteins
<p>Abstract</p> <p>Background</p> <p>Species of the family <it>Vibrionaceae </it>are ubiquitous in marine environments. Several of these species are important pathogens of humans and marine species. Evidence indicates that genetic exchange plays an important...
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| Format: | Article |
| Language: | English |
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BMC
2010-06-01
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| Series: | BMC Genomics |
| Online Access: | http://www.biomedcentral.com/1471-2164/11/369 |
| _version_ | 1818028643703586816 |
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| author | Cai Hong Gu Jianying Lilburn Timothy G Wang Yufeng |
| author_facet | Cai Hong Gu Jianying Lilburn Timothy G Wang Yufeng |
| author_sort | Cai Hong |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Species of the family <it>Vibrionaceae </it>are ubiquitous in marine environments. Several of these species are important pathogens of humans and marine species. Evidence indicates that genetic exchange plays an important role in the emergence of new pathogenic strains within this family. Data from the sequenced genomes of strains in this family could show how the genes encoded by all these strains, known as the pangenome, are distributed. Information about the core, accessory and panproteome of this family can show how, for example, genes encoding virulence-associated proteins are distributed and help us understand how virulence emerges.</p> <p>Results</p> <p>We deduced the complete set of orthologs for eleven strains from this family. The core proteome consists of 1,882 orthologous groups, which is 28% of the 6,629 orthologous groups in this family. There were 4,411 accessory orthologous groups (i.e., proteins that occurred in from 2 to 10 proteomes) and 5,584 unique proteins (encoded once on only one of the eleven genomes). Proteins that have been associated with virulence in <it>V. cholerae </it>were widely distributed across the eleven genomes, but the majority was found only on the genomes of the two <it>V. cholerae </it>strains examined.</p> <p>Conclusions</p> <p>The proteomes are reflective of the differing evolutionary trajectories followed by different strains to similar phenotypes. The composition of the proteomes supports the notion that genetic exchange among species of the <it>Vibrionaceae </it>is widespread and that this exchange aids these species in adapting to their environments.</p> |
| first_indexed | 2024-12-10T05:07:03Z |
| format | Article |
| id | doaj.art-1dc684c4b65e4d64b737fd6229bacd79 |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-12-10T05:07:03Z |
| publishDate | 2010-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj.art-1dc684c4b65e4d64b737fd6229bacd792022-12-22T02:01:12ZengBMCBMC Genomics1471-21642010-06-0111136910.1186/1471-2164-11-369Comparative genomics of the family <it>Vibrionaceae </it>reveals the wide distribution of genes encoding virulence-associated proteinsCai HongGu JianyingLilburn Timothy GWang Yufeng<p>Abstract</p> <p>Background</p> <p>Species of the family <it>Vibrionaceae </it>are ubiquitous in marine environments. Several of these species are important pathogens of humans and marine species. Evidence indicates that genetic exchange plays an important role in the emergence of new pathogenic strains within this family. Data from the sequenced genomes of strains in this family could show how the genes encoded by all these strains, known as the pangenome, are distributed. Information about the core, accessory and panproteome of this family can show how, for example, genes encoding virulence-associated proteins are distributed and help us understand how virulence emerges.</p> <p>Results</p> <p>We deduced the complete set of orthologs for eleven strains from this family. The core proteome consists of 1,882 orthologous groups, which is 28% of the 6,629 orthologous groups in this family. There were 4,411 accessory orthologous groups (i.e., proteins that occurred in from 2 to 10 proteomes) and 5,584 unique proteins (encoded once on only one of the eleven genomes). Proteins that have been associated with virulence in <it>V. cholerae </it>were widely distributed across the eleven genomes, but the majority was found only on the genomes of the two <it>V. cholerae </it>strains examined.</p> <p>Conclusions</p> <p>The proteomes are reflective of the differing evolutionary trajectories followed by different strains to similar phenotypes. The composition of the proteomes supports the notion that genetic exchange among species of the <it>Vibrionaceae </it>is widespread and that this exchange aids these species in adapting to their environments.</p>http://www.biomedcentral.com/1471-2164/11/369 |
| spellingShingle | Cai Hong Gu Jianying Lilburn Timothy G Wang Yufeng Comparative genomics of the family <it>Vibrionaceae </it>reveals the wide distribution of genes encoding virulence-associated proteins BMC Genomics |
| title | Comparative genomics of the family <it>Vibrionaceae </it>reveals the wide distribution of genes encoding virulence-associated proteins |
| title_full | Comparative genomics of the family <it>Vibrionaceae </it>reveals the wide distribution of genes encoding virulence-associated proteins |
| title_fullStr | Comparative genomics of the family <it>Vibrionaceae </it>reveals the wide distribution of genes encoding virulence-associated proteins |
| title_full_unstemmed | Comparative genomics of the family <it>Vibrionaceae </it>reveals the wide distribution of genes encoding virulence-associated proteins |
| title_short | Comparative genomics of the family <it>Vibrionaceae </it>reveals the wide distribution of genes encoding virulence-associated proteins |
| title_sort | comparative genomics of the family it vibrionaceae it reveals the wide distribution of genes encoding virulence associated proteins |
| url | http://www.biomedcentral.com/1471-2164/11/369 |
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