Synthesis and Pharmacological Evaluation of (+)-Usnic Acid Derivatives as Hypoglycemic Agents

Synthesis and Pharmacological Evaluation of (+)-Usnic Acid Derivatives as Hypoglycemic Agents

Usnic acid is produced by lichens and exhibits different biological properties, including hypoglycemic ones. However, this effect becomes noticeable only at relatively high doses, something that may lead to some adverse effects. The chemical modification of the molecule is able to enhance its safety...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Sergey A. Borisov, Olga A. Luzina, Mikhail V. Khvostov, Tatiana G. Tolstikova, Nariman F. Salakhutdinov
स्वरूप:	लेख
भाषा:	English
प्रकाशित:	MDPI AG 2022-10-01
श्रृंखला:	Molbank
विषय:	usnic acid enamines hypoglycemic action diabetes mellitus
ऑनलाइन पहुंच:	https://www.mdpi.com/1422-8599/2022/4/M1459

समान संसाधन

Regioselectivity Amination of Usnic Acid by Ammonia in Water
द्वारा: Aleksandr Filimonov, और अन्य
प्रकाशित: (2023-04-01)

Synthesis of Novel Thiazoles Based on (+)-Usnic Acid
द्वारा: Aleksandr S. Filimonov, और अन्य
प्रकाशित: (2024-10-01)

The Study of Hypoglycemic Activity of 7-Terpenylcoumarins
द्वारा: Sergey Kuranov, और अन्य
प्रकाशित: (2022-12-01)

Synthesis of a Novel 9-O Berberine Derivative and Evaluation of Its Hypoglycemic Effect
द्वारा: Elizaveta D. Gladkova, और अन्य
प्रकाशित: (2023-02-01)

Discovery of the First in Class 9-N-Berberine Derivative as Hypoglycemic Agent with Extra-Strong Action
द्वारा: Mikhail V. Khvostov, और अन्य
प्रकाशित: (2021-12-01)

Bornyl Derivatives of <i>p</i>-(Benzyloxy)Phenylpropionic Acid: In Vivo Evaluation of Antidiabetic Activity
द्वारा: Sergey Kuranov, और अन्य
प्रकाशित: (2020-11-01)

Triterpenic Acid Amides as a Promising Agent for Treatment of Metabolic Syndrome
द्वारा: Vladislav Fomenko, और अन्य
प्रकाशित: (2020-12-01)

9-N-n-alkyl Berberine Derivatives: Hypoglycemic Activity Evaluation
द्वारा: Mikhail V. Khvostov, और अन्य
प्रकाशित: (2022-12-01)

New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition
द्वारा: Nadezhda S. Dyrkheeva, और अन्य
प्रकाशित: (2021-07-01)

The Potential of Usnic-Acid-Based Thiazolo-Thiophenes as Inhibitors of the Main Protease of SARS-CoV-2 Viruses
द्वारा: Olga I. Yarovaya, और अन्य
प्रकाशित: (2024-01-01)

Pharmacogenetics of hypoglycemic agents
द्वारा: Irina Vladimirovna Kononenko, और अन्य
प्रकाशित: (2015-12-01)

Sulfide, Sulfoxide, and Sulfone Derivatives of Usnic Acid as Inhibitors of Human TDP1 and TDP2 Enzymes
द्वारा: Aleksandr S. Filimonov, और अन्य
प्रकाशित: (2024-12-01)

(+)-Usnic Acid as a Promising Candidate for a Safe and Stable Topical Photoprotective Agent
द्वारा: Agnieszka Galanty, और अन्य
प्रकाशित: (2021-08-01)

Critical Assessment of the Anti-Inflammatory Potential of Usnic Acid and Its Derivatives—A Review
द्वारा: Wojciech Paździora, और अन्य
प्रकाशित: (2023-04-01)

Bornyl-Containing Derivatives of Benzyloxyphenylpropanoic Acid as FFAR1 Agonists: In Vitro and In Vivo Studies
द्वारा: Darya A. Pon’kina, और अन्य
प्रकाशित: (2023-06-01)

Investigation of Apoptotic Effects of Usnic Acid on Hepatocellular Carcinoma
द्वारा: Beste Yurdacan, और अन्य
प्रकाशित: (2017-11-01)

New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors
द्वारा: Aleksander S. Filimonov, और अन्य
प्रकाशित: (2019-10-01)

Effects of the encapsulation of usnic acid into liposomes and interactions with antituberculous agents against multidrug-resistant tuberculosis clinical isolates
द्वारा: Rafaela S Ferraz-Carvalho, और अन्य
प्रकाशित: (2016-01-01)

Bioproduction of usnic acid from acetate by kaolinite immobilized cells of Cladonia substellata Vain.
द्वारा: Eugenia C. Pereira, और अन्य
प्रकाशित: (2014-01-01)

(+)-Usnic Acid and Its Derivatives as Inhibitors of a Wide Spectrum of SARS-CoV-2 Viruses
द्वारा: Aleksandr S. Filimonov, और अन्य
प्रकाशित: (2022-09-01)

Usnic acid brief exposure suppresses cariogenic properties and complexity of Streptococcus mutans biofilms
द्वारा: Santosh Pandit, और अन्य
प्रकाशित: (2024-12-01)

The Cytotoxic and Apoptotic Effects of Usnic Acid on Prostate Cancer versus Normal Cells
द्वारा: Işıl Ezgi Eryılmaz, और अन्य
प्रकाशित: (2017-11-01)

Advances in Research on Bioactivity, Toxicity, Metabolism, and Pharmacokinetics of Usnic Acid In Vitro and In Vivo
द्वारा: Hanxue Wang, और अन्य
प्रकाशित: (2022-11-01)

Nano- and Microcarriers as Drug Delivery Systems for Usnic Acid: Review of Literature
द्वारा: Ana Zugic, और अन्य
प्रकाशित: (2020-02-01)

Cytotoxic of Usnic Acid Isolated from Ramalina sp.
द्वारा: Akhmad Darmawan, और अन्य
प्रकाशित: (2024-07-01)

Multifaceted Properties of Usnic Acid in Disrupting Cancer Hallmarks
द्वारा: Mariola Gimła, और अन्य
प्रकाशित: (2024-09-01)

Hypoglycemic Effect of Betulin in Rats With Experimental Diabetes
द्वारा: Agnieszka Zakrzeska, और अन्य
प्रकाशित: (2023-11-01)

The cytotoxic effect of usnic acid in malignant melanoma cells with different genomic profiles in the BRAF aspect
द्वारा: C. Çolakoglu, और अन्य
प्रकाशित: (2022-03-01)

The Natural Compound Hydrophobic Usnic Acid and Hydrophilic Potassium Usnate Derivative: Applications and Comparisons
द्वारा: Hallysson Douglas Andrade de Araújo, और अन्य
प्रकाशित: (2021-10-01)

Usnic acid, a secondary metabolite of lichens and its effect on in vitro digestibility in reindeer
द्वारा: R. Thomas Palo
प्रकाशित: (1993-10-01)

Effects of Usnic Acid on Apoptosis and Expression of Bax and Bcl-2 Proteins in Hippocampal CA1 Neurons Following Cerebral Ischemia-Reperfusion
द्वारा: Sohaila Erfani, और अन्य
प्रकाशित: (2022-08-01)

The effect of tigecycline-usnic acid combination on tigecycline-non-susceptible Acinetobacter baumannii clinical isolates and the role of usnic acid as an adjuvant efflux pump inhibitor
द्वारा: Ghada Fahmy, और अन्य
प्रकाशित: (2024-11-01)

Effect of cyclic AMP and acridine orange on the enzymatic reduction of usnic acid in the lichen Usnea aurantiaco-atra (Jacq.) Bory
द्वारा: C. Vicente, और अन्य
प्रकाशित: (2014-01-01)

Bactericidal Activity of Usnic Acid-Chitosan Nanoparticles against Persister Cells of Biofilm-Forming Pathogenic Bacteria
द्वारा: Fazlurrahman Khan, और अन्य
प्रकाशित: (2020-05-01)

Hypoglycemic effect of <it>Carica papaya</it> leaves in streptozotocin-induced diabetic rats
द्वारा: Juárez-Rojop Isela Esther, और अन्य
प्रकाशित: (2012-11-01)

Antidiabetic Effect of Dihydrobetulonic Acid Derivatives as Pparα/γ Agonists
द्वारा: Mikhail V. Khvostov, और अन्य
प्रकाशित: (2024-12-01)

Hydrogel Formulation of Usnic Acid and Antibacterial Activity Test Against <i>Propionibacterium acne</i>
द्वारा: Lili Fitriani, और अन्य
प्रकाशित: (2018-12-01)

The pyrazole derivative of usnic acid inhibits the proliferation of pancreatic cancer cells in vitro and in vivo
द्वारा: Mariola Gimła, और अन्य
प्रकाशित: (2023-09-01)

Usnic Acid-Loaded Magnetite Nanoparticles—A Comparative Study between Synthesis Methods
द्वारा: Cristina Chircov, और अन्य
प्रकाशित: (2023-07-01)

Assessment of Type 2 Diabetes Patients’ Knowledge of Oral Hypoglycemic Agents
द्वारा: Milica Paut Kusturica, और अन्य
प्रकाशित: (2020-01-01)