Contribution of ROS and metabolic status to neonatal and adult CD8+ T cell activation.
In neonatal T cells, a low response to infection contributes to a high incidence of morbidity and mortality of neonates. Here we have evaluated the impact of the cytoplasmic and mitochondrial levels of Reactive Oxygen Species of adult and neonatal CD8+ T cells on their activation potential. We have...
| Egile Nagusiak: | , , , , , , , , |
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| Formatua: | Artikulua |
| Hizkuntza: | English |
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Public Library of Science (PLoS)
2019-01-01
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| Saila: | PLoS ONE |
| Sarrera elektronikoa: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0226388&type=printable |
| _version_ | 1826574132631830528 |
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| author | José Antonio Sánchez-Villanueva Otoniel Rodríguez-Jorge Oscar Ramírez-Pliego Gabriela Rosas Salgado Wassim Abou-Jaoudé Céline Hernandez Aurélien Naldi Denis Thieffry María Angélica Santana |
| author_facet | José Antonio Sánchez-Villanueva Otoniel Rodríguez-Jorge Oscar Ramírez-Pliego Gabriela Rosas Salgado Wassim Abou-Jaoudé Céline Hernandez Aurélien Naldi Denis Thieffry María Angélica Santana |
| author_sort | José Antonio Sánchez-Villanueva |
| collection | DOAJ |
| description | In neonatal T cells, a low response to infection contributes to a high incidence of morbidity and mortality of neonates. Here we have evaluated the impact of the cytoplasmic and mitochondrial levels of Reactive Oxygen Species of adult and neonatal CD8+ T cells on their activation potential. We have also constructed a logical model connecting metabolism and ROS with T cell signaling. Our model indicates the interplay between antigen recognition, ROS and metabolic status in T cell responses. This model displays alternative stable states corresponding to different cell fates, i.e. quiescent, activated and anergic states, depending on ROS levels. Stochastic simulations with this model further indicate that differences in ROS status at the cell population level contribute to the lower activation rate of neonatal, compared to adult, CD8+ T cells upon TCR engagement. These results are relevant for neonatal health care. Our model can serve to analyze the impact of metabolic shift during cancer in which, similar to neonatal cells, a high glycolytic rate and low concentrations of glutamine and arginine promote tumor tolerance. |
| first_indexed | 2024-12-16T06:38:48Z |
| format | Article |
| id | doaj.art-1dc8df30e3e543f6a8b40c61e5f17a6f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2025-03-14T12:53:57Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1dc8df30e3e543f6a8b40c61e5f17a6f2025-03-02T05:34:16ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-011412e022638810.1371/journal.pone.0226388Contribution of ROS and metabolic status to neonatal and adult CD8+ T cell activation.José Antonio Sánchez-VillanuevaOtoniel Rodríguez-JorgeOscar Ramírez-PliegoGabriela Rosas SalgadoWassim Abou-JaoudéCéline HernandezAurélien NaldiDenis ThieffryMaría Angélica SantanaIn neonatal T cells, a low response to infection contributes to a high incidence of morbidity and mortality of neonates. Here we have evaluated the impact of the cytoplasmic and mitochondrial levels of Reactive Oxygen Species of adult and neonatal CD8+ T cells on their activation potential. We have also constructed a logical model connecting metabolism and ROS with T cell signaling. Our model indicates the interplay between antigen recognition, ROS and metabolic status in T cell responses. This model displays alternative stable states corresponding to different cell fates, i.e. quiescent, activated and anergic states, depending on ROS levels. Stochastic simulations with this model further indicate that differences in ROS status at the cell population level contribute to the lower activation rate of neonatal, compared to adult, CD8+ T cells upon TCR engagement. These results are relevant for neonatal health care. Our model can serve to analyze the impact of metabolic shift during cancer in which, similar to neonatal cells, a high glycolytic rate and low concentrations of glutamine and arginine promote tumor tolerance.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0226388&type=printable |
| spellingShingle | José Antonio Sánchez-Villanueva Otoniel Rodríguez-Jorge Oscar Ramírez-Pliego Gabriela Rosas Salgado Wassim Abou-Jaoudé Céline Hernandez Aurélien Naldi Denis Thieffry María Angélica Santana Contribution of ROS and metabolic status to neonatal and adult CD8+ T cell activation. PLoS ONE |
| title | Contribution of ROS and metabolic status to neonatal and adult CD8+ T cell activation. |
| title_full | Contribution of ROS and metabolic status to neonatal and adult CD8+ T cell activation. |
| title_fullStr | Contribution of ROS and metabolic status to neonatal and adult CD8+ T cell activation. |
| title_full_unstemmed | Contribution of ROS and metabolic status to neonatal and adult CD8+ T cell activation. |
| title_short | Contribution of ROS and metabolic status to neonatal and adult CD8+ T cell activation. |
| title_sort | contribution of ros and metabolic status to neonatal and adult cd8 t cell activation |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0226388&type=printable |
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