Cytotoxicity of three new triazolo-pyrimidine derivatives against the plant trypanosomatid: Phytomonas sp. isolated from Euphorbia characias
There is no effective chemotherapy against diseases caused by Phytomonas sp., a plant trypanosomatid responsible for economic losses in major crops. We tested three triazolo-pyrimidine complexes [two with Pt(II), and another with Ru(III)] against promastigotes of Phytomonas sp. isolated from Euphorb...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2004-10-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000600021 |
| _version_ | 1797757164157140992 |
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| author | Rosa Magán Clotilde Marín Juan M Salas Mario Barrera-Pérez Maria J Rosales Manuel Sánchez-Moreno |
| author_facet | Rosa Magán Clotilde Marín Juan M Salas Mario Barrera-Pérez Maria J Rosales Manuel Sánchez-Moreno |
| author_sort | Rosa Magán |
| collection | DOAJ |
| description | There is no effective chemotherapy against diseases caused by Phytomonas sp., a plant trypanosomatid responsible for economic losses in major crops. We tested three triazolo-pyrimidine complexes [two with Pt(II), and another with Ru(III)] against promastigotes of Phytomonas sp. isolated from Euphorbia characias. The incorporation of radiolabelled precursors, ultrastructural alterations and changes in the pattern of metabolite excretion were examined. Different degrees of toxicity were found for each complex: the platinun compound showed an inhibition effect on nucleic acid synthesis, provoking alterations on the levels of mitochondria, nucleus and glycosomes. These results, together with others reported previously in our laboratory about the activity of pyrimidine derivatives, reflect the potential of these compounds as agents in the treatment of Phytomonas sp. |
| first_indexed | 2024-03-12T18:11:01Z |
| format | Article |
| id | doaj.art-1dc968ea43cc4baaa8170a6513fa0fea |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:11:01Z |
| publishDate | 2004-10-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-1dc968ea43cc4baaa8170a6513fa0fea2023-08-02T09:15:23ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602004-10-0199665165610.1590/S0074-02762004000600021Cytotoxicity of three new triazolo-pyrimidine derivatives against the plant trypanosomatid: Phytomonas sp. isolated from Euphorbia characiasRosa MagánClotilde MarínJuan M SalasMario Barrera-PérezMaria J RosalesManuel Sánchez-MorenoThere is no effective chemotherapy against diseases caused by Phytomonas sp., a plant trypanosomatid responsible for economic losses in major crops. We tested three triazolo-pyrimidine complexes [two with Pt(II), and another with Ru(III)] against promastigotes of Phytomonas sp. isolated from Euphorbia characias. The incorporation of radiolabelled precursors, ultrastructural alterations and changes in the pattern of metabolite excretion were examined. Different degrees of toxicity were found for each complex: the platinun compound showed an inhibition effect on nucleic acid synthesis, provoking alterations on the levels of mitochondria, nucleus and glycosomes. These results, together with others reported previously in our laboratory about the activity of pyrimidine derivatives, reflect the potential of these compounds as agents in the treatment of Phytomonas sp.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000600021Phytomonas sp.triazolo-pyrimidine complexeschemotherapeutic agents |
| spellingShingle | Rosa Magán Clotilde Marín Juan M Salas Mario Barrera-Pérez Maria J Rosales Manuel Sánchez-Moreno Cytotoxicity of three new triazolo-pyrimidine derivatives against the plant trypanosomatid: Phytomonas sp. isolated from Euphorbia characias Memorias do Instituto Oswaldo Cruz Phytomonas sp. triazolo-pyrimidine complexes chemotherapeutic agents |
| title | Cytotoxicity of three new triazolo-pyrimidine derivatives against the plant trypanosomatid: Phytomonas sp. isolated from Euphorbia characias |
| title_full | Cytotoxicity of three new triazolo-pyrimidine derivatives against the plant trypanosomatid: Phytomonas sp. isolated from Euphorbia characias |
| title_fullStr | Cytotoxicity of three new triazolo-pyrimidine derivatives against the plant trypanosomatid: Phytomonas sp. isolated from Euphorbia characias |
| title_full_unstemmed | Cytotoxicity of three new triazolo-pyrimidine derivatives against the plant trypanosomatid: Phytomonas sp. isolated from Euphorbia characias |
| title_short | Cytotoxicity of three new triazolo-pyrimidine derivatives against the plant trypanosomatid: Phytomonas sp. isolated from Euphorbia characias |
| title_sort | cytotoxicity of three new triazolo pyrimidine derivatives against the plant trypanosomatid phytomonas sp isolated from euphorbia characias |
| topic | Phytomonas sp. triazolo-pyrimidine complexes chemotherapeutic agents |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000600021 |
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