Rhinovirus and Innate Immune Function of Airway Epithelium
Airway epithelial cells, which lines the respiratory mucosa is in direct contact with the environment. Airway epithelial cells are the primary target for rhinovirus and other inhaled pathogens. In response to rhinovirus infection, airway epithelial cells mount both pro-inflammatory responses and ant...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcimb.2020.00277/full |
| _version_ | 1828523359710740480 |
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| author | Haleh Ganjian Charu Rajput Manal Elzoheiry Umadevi Sajjan Umadevi Sajjan |
| author_facet | Haleh Ganjian Charu Rajput Manal Elzoheiry Umadevi Sajjan Umadevi Sajjan |
| author_sort | Haleh Ganjian |
| collection | DOAJ |
| description | Airway epithelial cells, which lines the respiratory mucosa is in direct contact with the environment. Airway epithelial cells are the primary target for rhinovirus and other inhaled pathogens. In response to rhinovirus infection, airway epithelial cells mount both pro-inflammatory responses and antiviral innate immune responses to clear the virus efficiently. Some of the antiviral responses include the expression of IFNs, endoplasmic reticulum stress induced unfolded protein response and autophagy. Airway epithelial cells also recruits other innate immune cells to establish antiviral state and resolve the inflammation in the lungs. In patients with chronic lung disease, these responses may be either defective or induced in excess leading to deficient clearing of virus and sustained inflammation. In this review, we will discuss the mechanisms underlying antiviral innate immunity and the dysregulation of some of these mechanisms in patients with chronic lung diseases. |
| first_indexed | 2024-12-11T20:26:13Z |
| format | Article |
| id | doaj.art-1dca93a2fc6845339abac6f6b071340b |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-11T20:26:13Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-1dca93a2fc6845339abac6f6b071340b2022-12-22T00:51:57ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882020-06-011010.3389/fcimb.2020.00277543942Rhinovirus and Innate Immune Function of Airway EpitheliumHaleh Ganjian0Charu Rajput1Manal Elzoheiry2Umadevi Sajjan3Umadevi Sajjan4Department of Thoracic Medicine and Surgery, Lewis Katz Medical School, Temple University, Philadelphia, PA, United StatesDepartment of Thoracic Medicine and Surgery, Lewis Katz Medical School, Temple University, Philadelphia, PA, United StatesDepartment of Thoracic Medicine and Surgery, Lewis Katz Medical School, Temple University, Philadelphia, PA, United StatesDepartment of Thoracic Medicine and Surgery, Lewis Katz Medical School, Temple University, Philadelphia, PA, United StatesDepartment of Physiology, Lewis Katz Medical School, Temple University, Philadelphia, PA, United StatesAirway epithelial cells, which lines the respiratory mucosa is in direct contact with the environment. Airway epithelial cells are the primary target for rhinovirus and other inhaled pathogens. In response to rhinovirus infection, airway epithelial cells mount both pro-inflammatory responses and antiviral innate immune responses to clear the virus efficiently. Some of the antiviral responses include the expression of IFNs, endoplasmic reticulum stress induced unfolded protein response and autophagy. Airway epithelial cells also recruits other innate immune cells to establish antiviral state and resolve the inflammation in the lungs. In patients with chronic lung disease, these responses may be either defective or induced in excess leading to deficient clearing of virus and sustained inflammation. In this review, we will discuss the mechanisms underlying antiviral innate immunity and the dysregulation of some of these mechanisms in patients with chronic lung diseases.https://www.frontiersin.org/article/10.3389/fcimb.2020.00277/fulldsRNArhinovirusantiviral responsesER stressautophagyCOPD |
| spellingShingle | Haleh Ganjian Charu Rajput Manal Elzoheiry Umadevi Sajjan Umadevi Sajjan Rhinovirus and Innate Immune Function of Airway Epithelium Frontiers in Cellular and Infection Microbiology dsRNA rhinovirus antiviral responses ER stress autophagy COPD |
| title | Rhinovirus and Innate Immune Function of Airway Epithelium |
| title_full | Rhinovirus and Innate Immune Function of Airway Epithelium |
| title_fullStr | Rhinovirus and Innate Immune Function of Airway Epithelium |
| title_full_unstemmed | Rhinovirus and Innate Immune Function of Airway Epithelium |
| title_short | Rhinovirus and Innate Immune Function of Airway Epithelium |
| title_sort | rhinovirus and innate immune function of airway epithelium |
| topic | dsRNA rhinovirus antiviral responses ER stress autophagy COPD |
| url | https://www.frontiersin.org/article/10.3389/fcimb.2020.00277/full |
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