Respiratory viral infections in pediatric patients with hematopoietic stem cell transplantation
Background: Viral respiratory infections in pediatric patients with hematopoietic stem cell transplantation (HSCT) significantly impact morbidity and mortality. It is necessary to determine the viral agents and their frequency of presentation to understand their impact on transplantation patients’ e...
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| Format: | Article |
| Language: | English |
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Permanyer
2021-07-01
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| Series: | Boletín Médico del Hospital Infantil de México |
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| Online Access: | https://www.bmhim.com/frame_esp.php?id=232 |
| _version_ | 1828141711201665024 |
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| author | José F. Gaytán-Morales Iván Castorena-Villa Dolores C. Cortés-Flores Martha J. Avilés-Robles José L. Sánchez-Huerta Vianney Ortiz-Navarrete Irlanda Olvera-Gómez Briceida López-Martínez Israel Parra-Ortega |
| author_facet | José F. Gaytán-Morales Iván Castorena-Villa Dolores C. Cortés-Flores Martha J. Avilés-Robles José L. Sánchez-Huerta Vianney Ortiz-Navarrete Irlanda Olvera-Gómez Briceida López-Martínez Israel Parra-Ortega |
| author_sort | José F. Gaytán-Morales |
| collection | DOAJ |
| description | Background: Viral respiratory infections in pediatric patients with hematopoietic stem cell transplantation (HSCT) significantly impact morbidity and mortality. It is necessary to determine the viral agents and their frequency of presentation to understand their impact on transplantation patients’ evolution. Methods: From January 2017 to December 2019, we conducted a cross-sectional, descriptive, and observational study of patients who underwent HSCT with a viral respiratory infection. Viral identification was performed using multiplex polymerase chain reaction for nine respiratory viruses. Descriptive statistics were performed with a report of central tendency measures and percentages. Results: Of the 54 pediatric patients who underwent HSCT, 59.2% presented an airway infection; in turn, at least one viral agent was identified in 59.3% of these patients. The most frequent viral agents were influenza (25.9%), human rhinovirus (18.5%), and respiratory syncytial virus (18.5%). Viral co-infections occurred in 36.8% of the cases. The reported complications were supplemental oxygen requirement (73.6%), support with mechanical ventilation (21%), admission to the pediatric intensive care unit (15.7%), and mortality associated with a viral respiratory infection (10.5%). Conclusions: Viral respiratory infections are frequent in pediatric patients with HSCT; influenza A/B virus was the most frequent agent. As morbidity and mortality increase due to these infections in patients with HSCT, strategies are necessary for its prevention and timely treatment after transplantation. |
| first_indexed | 2024-04-11T19:29:21Z |
| format | Article |
| id | doaj.art-1dcbfe99bb1f47879378d2d118adce5e |
| institution | Directory Open Access Journal |
| issn | 0539-6115 |
| language | English |
| last_indexed | 2024-04-11T19:29:21Z |
| publishDate | 2021-07-01 |
| publisher | Permanyer |
| record_format | Article |
| series | Boletín Médico del Hospital Infantil de México |
| spelling | doaj.art-1dcbfe99bb1f47879378d2d118adce5e2022-12-22T04:07:02ZengPermanyerBoletín Médico del Hospital Infantil de México0539-61152021-07-0178310.24875/BMHIM.20000126Respiratory viral infections in pediatric patients with hematopoietic stem cell transplantationJosé F. Gaytán-Morales0Iván Castorena-Villa1Dolores C. Cortés-Flores2Martha J. Avilés-Robles3José L. Sánchez-Huerta4Vianney Ortiz-Navarrete5Irlanda Olvera-Gómez6Briceida López-Martínez7Israel Parra-Ortega8Servicio de Trasplante de Médula Ósea, Hospital Infantil de México Federico Gómez, Mexico City, MexicoServicio de Trasplante de Médula Ósea, Hospital Infantil de México Federico Gómez, Mexico City, MexicoServicio de Trasplante de Médula Ósea, Hospital Infantil de México Federico Gómez, Mexico City, MexicoDepartamento de Infectología Pediátrica, Hospital Infantil de México Federico Gómez, Mexico City, MexicoDepartamento de Laboratorio Clínico, Hospital Infantil de México Federico Gómez, Mexico City, MexicoCentro de Investigación y Estudios Avanzados, Instituto Politécnico Nacional, Mexico City, MexicoHospitales Federales de Referencia, Hospital Nacional Homeopático, Mexico City; Universidad Anáhuac Norte, Naucalpan de Juárez, State of Mexico; MexicoSubdirección de Servicios Auxiliares de Diagnóstico, Mexico City. MexicoDepartamento de Laboratorio Clínico, Hospital Infantil de México Federico Gómez, Mexico City, MexicoBackground: Viral respiratory infections in pediatric patients with hematopoietic stem cell transplantation (HSCT) significantly impact morbidity and mortality. It is necessary to determine the viral agents and their frequency of presentation to understand their impact on transplantation patients’ evolution. Methods: From January 2017 to December 2019, we conducted a cross-sectional, descriptive, and observational study of patients who underwent HSCT with a viral respiratory infection. Viral identification was performed using multiplex polymerase chain reaction for nine respiratory viruses. Descriptive statistics were performed with a report of central tendency measures and percentages. Results: Of the 54 pediatric patients who underwent HSCT, 59.2% presented an airway infection; in turn, at least one viral agent was identified in 59.3% of these patients. The most frequent viral agents were influenza (25.9%), human rhinovirus (18.5%), and respiratory syncytial virus (18.5%). Viral co-infections occurred in 36.8% of the cases. The reported complications were supplemental oxygen requirement (73.6%), support with mechanical ventilation (21%), admission to the pediatric intensive care unit (15.7%), and mortality associated with a viral respiratory infection (10.5%). Conclusions: Viral respiratory infections are frequent in pediatric patients with HSCT; influenza A/B virus was the most frequent agent. As morbidity and mortality increase due to these infections in patients with HSCT, strategies are necessary for its prevention and timely treatment after transplantation.https://www.bmhim.com/frame_esp.php?id=232Stem cell transplantation. Respiratory tract infections. Respiratory virus. |
| spellingShingle | José F. Gaytán-Morales Iván Castorena-Villa Dolores C. Cortés-Flores Martha J. Avilés-Robles José L. Sánchez-Huerta Vianney Ortiz-Navarrete Irlanda Olvera-Gómez Briceida López-Martínez Israel Parra-Ortega Respiratory viral infections in pediatric patients with hematopoietic stem cell transplantation Boletín Médico del Hospital Infantil de México Stem cell transplantation. Respiratory tract infections. Respiratory virus. |
| title | Respiratory viral infections in pediatric patients with hematopoietic stem cell transplantation |
| title_full | Respiratory viral infections in pediatric patients with hematopoietic stem cell transplantation |
| title_fullStr | Respiratory viral infections in pediatric patients with hematopoietic stem cell transplantation |
| title_full_unstemmed | Respiratory viral infections in pediatric patients with hematopoietic stem cell transplantation |
| title_short | Respiratory viral infections in pediatric patients with hematopoietic stem cell transplantation |
| title_sort | respiratory viral infections in pediatric patients with hematopoietic stem cell transplantation |
| topic | Stem cell transplantation. Respiratory tract infections. Respiratory virus. |
| url | https://www.bmhim.com/frame_esp.php?id=232 |
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