Clinical Significance of Hotspot Mutation Analysis of Urinary Cell-Free DNA in Urothelial Bladder Cancer

Clinical Significance of Hotspot Mutation Analysis of Urinary Cell-Free DNA in Urothelial Bladder Cancer

Recent studies showed the clinical utility of next-generation sequencing of urinary cell-free DNA (cfDNA) from patients with urothelial bladder cancer (UBC). In this study, we aimed to develop urinary cfDNA analysis by droplet digital PCR (ddPCR) as a high-throughput and rapid assay for UBC detectio...

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Bibliographic Details
Main Authors: Yujiro Hayashi, Kazutoshi Fujita, Kyosuke Matsuzaki, Marie-Lisa Eich, Eisuke Tomiyama, Makoto Matsushita, Yoko Koh, Kosuke Nakano, Cong Wang, Yu Ishizuya, Taigo Kato, Koji Hatano, Atsunari Kawashima, Takeshi Ujike, Motohide Uemura, Ryoichi Imamura, George J. Netto, Norio Nonomura
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Oncology
Subjects:
bladder cancer
TERT promoter
FGFR3
cell-free DNA
liquid biopsy
UroVysion
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00755/full

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