Sepsis with Staphylococcus aureus in child with selective IgA deficiency and SARS-CoV-2 infection - case presentation
Sepsis is one of the most severe pediatric infectious diseases that can progress to serious complications or even death without specialized treatment. It often evolves as a complication of a viral illness or against the background of a depressed host immune terrain. SARS-CoV-2 infection is a self-l...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2023-03-01
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| Series: | Romanian Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | https://rjid.com.ro/articles/2023.1/RJID_2023_1_Art-06.pdf |
| _version_ | 1797743564878249984 |
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| author | Gheorghita Jugulete Mihaela Safta Elena Gheorghe Bianca Borcos Monica Luminos Madalina Merisescu |
| author_facet | Gheorghita Jugulete Mihaela Safta Elena Gheorghe Bianca Borcos Monica Luminos Madalina Merisescu |
| author_sort | Gheorghita Jugulete |
| collection | DOAJ |
| description | Sepsis is one of the most severe pediatric infectious diseases that can progress to serious complications or even death without specialized treatment. It often evolves as a complication of a viral illness or against the background of a depressed host immune terrain.
SARS-CoV-2 infection is a self-limiting viral infection in children, which is rarely complicated, especially in immunocompromised or co-morbid individuals.
In this paper we present a clinical case of a 1 year and 2 months old child admitted to the Pediatric Infectious Diseases Clinical Department IX of the National Institute of Infectious Diseases “Prof. Dr. Matei Bals” with the diagnosis of SARS-CoV-2 infection. The positive diagnosis was established on epidemiological data (parents with SARS-CoV-2 infection), suggestive clinical picture (fever, inappetence, vomiting) and confirmed by RT-PCR. 72 hours after admission, with favorable clinical evolution, the child presented again fever and chills. Laboratory investigations show leukocytosis with neutrophilia, inflammatory syndrome present and, in nasal exudate and blood culture, staphylococcus aureus MSSA is isolated. Also, immunogram shows low IgA level, the rest of the laboratory tests are within normal limits. Antibiotic treatment was instituted, symptomatic hydroelectrolytic and acid-base rebalancing infusions with favourable evolution.
The case presented shows that although SARS-CoV-2 infection is often a mild condition in children, it can evolve severely, especially in immunosuppressed individuals with comorbidities. The presented child was not known to have selective IgA immunodeficiency, which probably in combination with COVID-19 induced immunosuppression, favored the development of sepsis. |
| first_indexed | 2024-03-12T14:57:16Z |
| format | Article |
| id | doaj.art-1dccde7bd1d8495a82725a7f93476895 |
| institution | Directory Open Access Journal |
| issn | 1454-3389 2069-6051 |
| language | English |
| last_indexed | 2024-03-12T14:57:16Z |
| publishDate | 2023-03-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Infectious Diseases |
| spelling | doaj.art-1dccde7bd1d8495a82725a7f934768952023-08-14T14:58:57ZengAmaltea Medical Publishing HouseRomanian Journal of Infectious Diseases1454-33892069-60512023-03-01261384110.37897/RJID.2023.1.6Sepsis with Staphylococcus aureus in child with selective IgA deficiency and SARS-CoV-2 infection - case presentationGheorghita Jugulete0Mihaela Safta1Elena Gheorghe2Bianca Borcos3Monica Luminos4Madalina Merisescu5“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; “Prof. Dr. Matei Bals” National Institute for Infectious Diseases, Bucharest, Romania“Prof. Dr. Matei Bals” National Institute for Infectious Diseases, Bucharest, Romania“Prof. Dr. Matei Bals” National Institute for Infectious Diseases, Bucharest, Romania“Prof. Dr. Matei Bals” National Institute for Infectious Diseases, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; “Prof. Dr. Matei Bals” National Institute for Infectious Diseases, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; “Prof. Dr. Matei Bals” National Institute for Infectious Diseases, Bucharest, RomaniaSepsis is one of the most severe pediatric infectious diseases that can progress to serious complications or even death without specialized treatment. It often evolves as a complication of a viral illness or against the background of a depressed host immune terrain. SARS-CoV-2 infection is a self-limiting viral infection in children, which is rarely complicated, especially in immunocompromised or co-morbid individuals. In this paper we present a clinical case of a 1 year and 2 months old child admitted to the Pediatric Infectious Diseases Clinical Department IX of the National Institute of Infectious Diseases “Prof. Dr. Matei Bals” with the diagnosis of SARS-CoV-2 infection. The positive diagnosis was established on epidemiological data (parents with SARS-CoV-2 infection), suggestive clinical picture (fever, inappetence, vomiting) and confirmed by RT-PCR. 72 hours after admission, with favorable clinical evolution, the child presented again fever and chills. Laboratory investigations show leukocytosis with neutrophilia, inflammatory syndrome present and, in nasal exudate and blood culture, staphylococcus aureus MSSA is isolated. Also, immunogram shows low IgA level, the rest of the laboratory tests are within normal limits. Antibiotic treatment was instituted, symptomatic hydroelectrolytic and acid-base rebalancing infusions with favourable evolution. The case presented shows that although SARS-CoV-2 infection is often a mild condition in children, it can evolve severely, especially in immunosuppressed individuals with comorbidities. The presented child was not known to have selective IgA immunodeficiency, which probably in combination with COVID-19 induced immunosuppression, favored the development of sepsis.https://rjid.com.ro/articles/2023.1/RJID_2023_1_Art-06.pdfsepsisstaphylococcus aureuschildsars-cov-2iga deficiency |
| spellingShingle | Gheorghita Jugulete Mihaela Safta Elena Gheorghe Bianca Borcos Monica Luminos Madalina Merisescu Sepsis with Staphylococcus aureus in child with selective IgA deficiency and SARS-CoV-2 infection - case presentation Romanian Journal of Infectious Diseases sepsis staphylococcus aureus child sars-cov-2 iga deficiency |
| title | Sepsis with Staphylococcus aureus in child with selective IgA deficiency and SARS-CoV-2 infection - case presentation |
| title_full | Sepsis with Staphylococcus aureus in child with selective IgA deficiency and SARS-CoV-2 infection - case presentation |
| title_fullStr | Sepsis with Staphylococcus aureus in child with selective IgA deficiency and SARS-CoV-2 infection - case presentation |
| title_full_unstemmed | Sepsis with Staphylococcus aureus in child with selective IgA deficiency and SARS-CoV-2 infection - case presentation |
| title_short | Sepsis with Staphylococcus aureus in child with selective IgA deficiency and SARS-CoV-2 infection - case presentation |
| title_sort | sepsis with staphylococcus aureus in child with selective iga deficiency and sars cov 2 infection case presentation |
| topic | sepsis staphylococcus aureus child sars-cov-2 iga deficiency |
| url | https://rjid.com.ro/articles/2023.1/RJID_2023_1_Art-06.pdf |
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