Differential characteristics among asymptomatic and symptomatic meibomian gland dysfunction and those with dry eye
Abstract Purpose To identify the characteristics of asymptomatic meibomian gland dysfunction (MGD), symptomatic MGD, and MGD coexisting with dry eye disease (DED). Methods This cross sectional study enrolled a total of 153 eyes of 87 MGD patients. Participants filled in ocular surface disease index...
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| Format: | Article |
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BMC
2023-04-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-023-02878-5 |
| _version_ | 1827966371747594240 |
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| author | Yi-Ran Chiou Pei-Yu Lin Yu-Bai Chou Po-Wei Huang Nai-Wen Fan |
| author_facet | Yi-Ran Chiou Pei-Yu Lin Yu-Bai Chou Po-Wei Huang Nai-Wen Fan |
| author_sort | Yi-Ran Chiou |
| collection | DOAJ |
| description | Abstract Purpose To identify the characteristics of asymptomatic meibomian gland dysfunction (MGD), symptomatic MGD, and MGD coexisting with dry eye disease (DED). Methods This cross sectional study enrolled a total of 153 eyes of 87 MGD patients. Participants filled in ocular surface disease index (OSDI) questionnaires. Age, gender, Schirmer’s test, meibomian gland (MG) related parameters, lipid layer thickness (LLT) and blinking were compared among patients with asymptomatic MGD, symptomatic MGD, and MGD with DED. Multivariate regression was used to analyze the significant factor of DED in MGD. Spearman’s rank correlation analysis was used to evaluate the association between the significant factors and MG function. Results There was no difference in age, Schirmer’s test, lid changes, MG secretion, and MG morphology among three groups. The OSDI of asymptomatic MGD, symptomatic MGD and MGD coexisting with DED were 8.5 ± 2.9, 28.5 ± 12.8 and 27.9 ± 10.5, respectively. Patients with MGD coexisting with DED exhibited more frequent eye blinking than that of patients with asymptomatic MGD (8.1 ± 4.1 vs. 6.1 ± 3.5 blinks/20 sec, P = 0.022), and reduced LLT than that of patients with asymptomatic MGD (68.6 ± 17.2 vs. 77.6 ± 14.5 nm, P = 0.010) and symptomatic MGD (78.0 ± 17.1 nm, P = 0.015). Multivariate analysis identified LLT (per nm, OR = 0.96, 95% CI = 0.93—0.99, P = 0.002) as a significant factor associated with DED development in MGD. The number of expressible MG was positively correlated with LLT (Spearman’s correlation coefficient = 0.299, P = 0.016) but negatively correlated with the number of blinking (Spearman’s correlation coefficient = -0.298, P = 0.016) in MGD patients with DED, and these findings were not identified in those without DED. Conclusions Asymptomatic MGD, symptomatic MGD, and MGD coexisting with DED share similar characteristics, including meibum secretion and morphology, but MGD patients coexisting with DED exhibited significantly reduced LLT. |
| first_indexed | 2024-04-09T17:48:57Z |
| format | Article |
| id | doaj.art-1dcea8d9c25f43c5983b5058f87f4e68 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-04-09T17:48:57Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-1dcea8d9c25f43c5983b5058f87f4e682023-04-16T11:09:39ZengBMCBMC Ophthalmology1471-24152023-04-012311810.1186/s12886-023-02878-5Differential characteristics among asymptomatic and symptomatic meibomian gland dysfunction and those with dry eyeYi-Ran Chiou0Pei-Yu Lin1Yu-Bai Chou2Po-Wei Huang3Nai-Wen Fan4Department of Ophthalmology, Taipei Veterans General HospitalDepartment of Ophthalmology, Taipei Veterans General HospitalDepartment of Ophthalmology, Taipei Veterans General HospitalDepartment of Radiation Oncology, Shuang Ho Hospital, Taipei Medical UniversityDepartment of Ophthalmology, Taipei Veterans General HospitalAbstract Purpose To identify the characteristics of asymptomatic meibomian gland dysfunction (MGD), symptomatic MGD, and MGD coexisting with dry eye disease (DED). Methods This cross sectional study enrolled a total of 153 eyes of 87 MGD patients. Participants filled in ocular surface disease index (OSDI) questionnaires. Age, gender, Schirmer’s test, meibomian gland (MG) related parameters, lipid layer thickness (LLT) and blinking were compared among patients with asymptomatic MGD, symptomatic MGD, and MGD with DED. Multivariate regression was used to analyze the significant factor of DED in MGD. Spearman’s rank correlation analysis was used to evaluate the association between the significant factors and MG function. Results There was no difference in age, Schirmer’s test, lid changes, MG secretion, and MG morphology among three groups. The OSDI of asymptomatic MGD, symptomatic MGD and MGD coexisting with DED were 8.5 ± 2.9, 28.5 ± 12.8 and 27.9 ± 10.5, respectively. Patients with MGD coexisting with DED exhibited more frequent eye blinking than that of patients with asymptomatic MGD (8.1 ± 4.1 vs. 6.1 ± 3.5 blinks/20 sec, P = 0.022), and reduced LLT than that of patients with asymptomatic MGD (68.6 ± 17.2 vs. 77.6 ± 14.5 nm, P = 0.010) and symptomatic MGD (78.0 ± 17.1 nm, P = 0.015). Multivariate analysis identified LLT (per nm, OR = 0.96, 95% CI = 0.93—0.99, P = 0.002) as a significant factor associated with DED development in MGD. The number of expressible MG was positively correlated with LLT (Spearman’s correlation coefficient = 0.299, P = 0.016) but negatively correlated with the number of blinking (Spearman’s correlation coefficient = -0.298, P = 0.016) in MGD patients with DED, and these findings were not identified in those without DED. Conclusions Asymptomatic MGD, symptomatic MGD, and MGD coexisting with DED share similar characteristics, including meibum secretion and morphology, but MGD patients coexisting with DED exhibited significantly reduced LLT.https://doi.org/10.1186/s12886-023-02878-5Dry eye diseaseInterferometryLipid layer thicknessMeibomian gland dysfunctionOcular surface parameters |
| spellingShingle | Yi-Ran Chiou Pei-Yu Lin Yu-Bai Chou Po-Wei Huang Nai-Wen Fan Differential characteristics among asymptomatic and symptomatic meibomian gland dysfunction and those with dry eye BMC Ophthalmology Dry eye disease Interferometry Lipid layer thickness Meibomian gland dysfunction Ocular surface parameters |
| title | Differential characteristics among asymptomatic and symptomatic meibomian gland dysfunction and those with dry eye |
| title_full | Differential characteristics among asymptomatic and symptomatic meibomian gland dysfunction and those with dry eye |
| title_fullStr | Differential characteristics among asymptomatic and symptomatic meibomian gland dysfunction and those with dry eye |
| title_full_unstemmed | Differential characteristics among asymptomatic and symptomatic meibomian gland dysfunction and those with dry eye |
| title_short | Differential characteristics among asymptomatic and symptomatic meibomian gland dysfunction and those with dry eye |
| title_sort | differential characteristics among asymptomatic and symptomatic meibomian gland dysfunction and those with dry eye |
| topic | Dry eye disease Interferometry Lipid layer thickness Meibomian gland dysfunction Ocular surface parameters |
| url | https://doi.org/10.1186/s12886-023-02878-5 |
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