E3 ubiquitin ligases in the acute leukemic signaling pathways
Acute leukemia is a common hematologic tumor with highly genetic heterogeneity, and many factors are involved in the pathogenesis and drug-resistance mechanism. Emerging evidence proves that E3 ubiquitin ligases participate in the acute leukemic signaling pathways via regulating substrates. This rev...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.1004330/full |
| _version_ | 1797988389809553408 |
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| author | Qianru Zhan Heyang Zhang Boquan Wu Naijin Zhang Lijun Zhang |
| author_facet | Qianru Zhan Heyang Zhang Boquan Wu Naijin Zhang Lijun Zhang |
| author_sort | Qianru Zhan |
| collection | DOAJ |
| description | Acute leukemia is a common hematologic tumor with highly genetic heterogeneity, and many factors are involved in the pathogenesis and drug-resistance mechanism. Emerging evidence proves that E3 ubiquitin ligases participate in the acute leukemic signaling pathways via regulating substrates. This review summarized the E3 ligases which can affect the leukemic signal. It is worth noting that the abnormal signal is often caused by a deficiency or a mutation of the E3 ligases. In view of this phenomenon, we envisioned perspectives associated with targeted agonists of E3 ligases and proteolysis-targeting chimera technology. Moreover, we emphasized the significance of research into the upstream factors regulating the expression of E3 ubiquitin ligases. It is expected that the understanding of the mechanism of leukemic signaling pathways with which that E3 ligases are involved will be beneficial to accelerating the process of therapeutic strategy improvement for acute leukemia. |
| first_indexed | 2024-04-11T08:02:17Z |
| format | Article |
| id | doaj.art-1dcecb525c384ec7bc101010d81cb12e |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-11T08:02:17Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-1dcecb525c384ec7bc101010d81cb12e2022-12-22T04:35:40ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-11-011310.3389/fphys.2022.10043301004330E3 ubiquitin ligases in the acute leukemic signaling pathwaysQianru Zhan0Heyang Zhang1Boquan Wu2Naijin Zhang3Lijun Zhang4Department of Hematology, The First Hospital of China Medical University, Shenyang, ChinaDepartment of Hematology, The First Hospital of China Medical University, Shenyang, ChinaDepartment of Cardiology, The First Hospital of China Medical University, Shenyang, ChinaDepartment of Cardiology, The First Hospital of China Medical University, Shenyang, ChinaDepartment of Hematology, The First Hospital of China Medical University, Shenyang, ChinaAcute leukemia is a common hematologic tumor with highly genetic heterogeneity, and many factors are involved in the pathogenesis and drug-resistance mechanism. Emerging evidence proves that E3 ubiquitin ligases participate in the acute leukemic signaling pathways via regulating substrates. This review summarized the E3 ligases which can affect the leukemic signal. It is worth noting that the abnormal signal is often caused by a deficiency or a mutation of the E3 ligases. In view of this phenomenon, we envisioned perspectives associated with targeted agonists of E3 ligases and proteolysis-targeting chimera technology. Moreover, we emphasized the significance of research into the upstream factors regulating the expression of E3 ubiquitin ligases. It is expected that the understanding of the mechanism of leukemic signaling pathways with which that E3 ligases are involved will be beneficial to accelerating the process of therapeutic strategy improvement for acute leukemia.https://www.frontiersin.org/articles/10.3389/fphys.2022.1004330/fullE3 ubiquitin ligasesacute leukemiaNotchJAK2NF-κBPI3K/AKT |
| spellingShingle | Qianru Zhan Heyang Zhang Boquan Wu Naijin Zhang Lijun Zhang E3 ubiquitin ligases in the acute leukemic signaling pathways Frontiers in Physiology E3 ubiquitin ligases acute leukemia Notch JAK2 NF-κB PI3K/AKT |
| title | E3 ubiquitin ligases in the acute leukemic signaling pathways |
| title_full | E3 ubiquitin ligases in the acute leukemic signaling pathways |
| title_fullStr | E3 ubiquitin ligases in the acute leukemic signaling pathways |
| title_full_unstemmed | E3 ubiquitin ligases in the acute leukemic signaling pathways |
| title_short | E3 ubiquitin ligases in the acute leukemic signaling pathways |
| title_sort | e3 ubiquitin ligases in the acute leukemic signaling pathways |
| topic | E3 ubiquitin ligases acute leukemia Notch JAK2 NF-κB PI3K/AKT |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.1004330/full |
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