Oxidative DNA Damage and Cisplatin Neurotoxicity Is Exacerbated by Inhibition of OGG1 Glycosylase Activity and APE1 Endonuclease Activity in Sensory Neurons

Oxidative DNA Damage and Cisplatin Neurotoxicity Is Exacerbated by Inhibition of OGG1 Glycosylase Activity and APE1 Endonuclease Activity in Sensory Neurons

Cisplatin can induce peripheral neuropathy, which is a common complication of anti-cancer treatment and negatively impacts cancer survivors during and after completion of treatment; therefore, the mechanisms by which cisplatin alters sensory neuronal function to elicit neuropathy are the subject of...

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Bibliographic Details
Main Authors: Adib Behrouzi, Hanyu Xia, Eric L. Thompson, Mark R. Kelley, Jill C. Fehrenbacher
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
cisplatin
DNA damage
oxidative stress
chemotherapy-induced peripheral neuropathy
sensory neuron
neuropeptide
Online Access:https://www.mdpi.com/1422-0067/23/3/1909

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