The role of macrophage subsets in and around the heart in modulating cardiac homeostasis and pathophysiology
Cardiac and pericardial macrophages contribute to both homeostatic and pathophysiological processes. Recent advances have identified a vast repertoire of these macrophage populations in and around the heart - broadly categorized into a CCR2+/CCR2- dichotomy. While these unique populations can be fur...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1111819/full |
| _version_ | 1797893755975499776 |
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| author | Carmina Albertine Isidoro Carmina Albertine Isidoro Justin F. Deniset Justin F. Deniset Justin F. Deniset |
| author_facet | Carmina Albertine Isidoro Carmina Albertine Isidoro Justin F. Deniset Justin F. Deniset Justin F. Deniset |
| author_sort | Carmina Albertine Isidoro |
| collection | DOAJ |
| description | Cardiac and pericardial macrophages contribute to both homeostatic and pathophysiological processes. Recent advances have identified a vast repertoire of these macrophage populations in and around the heart - broadly categorized into a CCR2+/CCR2- dichotomy. While these unique populations can be further distinguished by origin, localization, and other cell surface markers, further exploration into the role of cardiac and pericardial macrophage subpopulations in disease contributes an additional layer of complexity. As such, novel transgenic models and exogenous targeting techniques have been employed to evaluate these macrophages. In this review, we highlight known cardiac and pericardial macrophage populations, their functions, and the experimental tools used to bolster our knowledge of these cells in the cardiac context. |
| first_indexed | 2024-04-10T06:57:55Z |
| format | Article |
| id | doaj.art-1dd242c6d0184e97b4f855b5db6c8f89 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T06:57:55Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-1dd242c6d0184e97b4f855b5db6c8f892023-02-28T05:47:03ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-02-011410.3389/fimmu.2023.11118191111819The role of macrophage subsets in and around the heart in modulating cardiac homeostasis and pathophysiologyCarmina Albertine Isidoro0Carmina Albertine Isidoro1Justin F. Deniset2Justin F. Deniset3Justin F. Deniset4Department of Physiology and Pharmacology, University of Calgary, Calgary, AB, CanadaLibin Cardiovascular Institute, Cumming School of Medicine, Calgary, AB, CanadaDepartment of Physiology and Pharmacology, University of Calgary, Calgary, AB, CanadaLibin Cardiovascular Institute, Cumming School of Medicine, Calgary, AB, CanadaDepartment of Cardiac Sciences, University of Calgary, Calgary, AB, CanadaCardiac and pericardial macrophages contribute to both homeostatic and pathophysiological processes. Recent advances have identified a vast repertoire of these macrophage populations in and around the heart - broadly categorized into a CCR2+/CCR2- dichotomy. While these unique populations can be further distinguished by origin, localization, and other cell surface markers, further exploration into the role of cardiac and pericardial macrophage subpopulations in disease contributes an additional layer of complexity. As such, novel transgenic models and exogenous targeting techniques have been employed to evaluate these macrophages. In this review, we highlight known cardiac and pericardial macrophage populations, their functions, and the experimental tools used to bolster our knowledge of these cells in the cardiac context.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1111819/fullmacrophagestissue-residentcardiacpericardial cavityremodeling |
| spellingShingle | Carmina Albertine Isidoro Carmina Albertine Isidoro Justin F. Deniset Justin F. Deniset Justin F. Deniset The role of macrophage subsets in and around the heart in modulating cardiac homeostasis and pathophysiology Frontiers in Immunology macrophages tissue-resident cardiac pericardial cavity remodeling |
| title | The role of macrophage subsets in and around the heart in modulating cardiac homeostasis and pathophysiology |
| title_full | The role of macrophage subsets in and around the heart in modulating cardiac homeostasis and pathophysiology |
| title_fullStr | The role of macrophage subsets in and around the heart in modulating cardiac homeostasis and pathophysiology |
| title_full_unstemmed | The role of macrophage subsets in and around the heart in modulating cardiac homeostasis and pathophysiology |
| title_short | The role of macrophage subsets in and around the heart in modulating cardiac homeostasis and pathophysiology |
| title_sort | role of macrophage subsets in and around the heart in modulating cardiac homeostasis and pathophysiology |
| topic | macrophages tissue-resident cardiac pericardial cavity remodeling |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1111819/full |
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