Advantage of whole-mount histopathology in prostate cancer: current applications and future prospects
Abstract Background Whole-mount histopathology (WMH) has been a powerful tool to investigate the characteristics of prostate cancer. However, the latest advancement of WMH was yet under summarization. In this review, we offer a comprehensive exposition of current research utilizing WMH in diagnosing...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-024-12071-6 |
| _version_ | 1797209261055410176 |
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| author | Lewei Duan Zheng Liu Fangning Wan Bo Dai |
| author_facet | Lewei Duan Zheng Liu Fangning Wan Bo Dai |
| author_sort | Lewei Duan |
| collection | DOAJ |
| description | Abstract Background Whole-mount histopathology (WMH) has been a powerful tool to investigate the characteristics of prostate cancer. However, the latest advancement of WMH was yet under summarization. In this review, we offer a comprehensive exposition of current research utilizing WMH in diagnosing and treating prostate cancer (PCa), and summarize the clinical advantages of WMH and outlines potential on future prospects. Methods An extensive PubMed search was conducted until February 26, 2023, with the search term “prostate”, “whole-mount”, “large format histology”, which was limited to the last 4 years. Publications included were restricted to those in English. Other papers were also cited to contribute a better understanding. Results WMH exhibits an enhanced legibility for pathologists, which improved the efficacy of pathologic examination and provide educational value. It simplifies the histopathological registration with medical images, which serves as a convincing reference standard for imaging indicator investigation and medical image-based artificial intelligence (AI). Additionally, WMH provides comprehensive histopathological information for tumor volume estimation, post-treatment evaluation, and provides direct pathological data for AI readers. It also offers complete spatial context for the location estimation of both intraprostatic and extraprostatic cancerous region. Conclusions WMH provides unique benefits in several aspects of clinical diagnosis and treatment of PCa. The utilization of WMH technique facilitates the development and refinement of various clinical technologies. We believe that WMH will play an important role in future clinical applications. |
| first_indexed | 2024-04-24T09:51:53Z |
| format | Article |
| id | doaj.art-1dd414b148484964963e5cb1980e3019 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-24T09:51:53Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-1dd414b148484964963e5cb1980e30192024-04-14T11:18:58ZengBMCBMC Cancer1471-24072024-04-0124111310.1186/s12885-024-12071-6Advantage of whole-mount histopathology in prostate cancer: current applications and future prospectsLewei Duan0Zheng Liu1Fangning Wan2Bo Dai3Department of Urology, Fudan University Shanghai Cancer CenterDepartment of Urology, Fudan University Shanghai Cancer CenterDepartment of Urology, Fudan University Shanghai Cancer CenterDepartment of Urology, Fudan University Shanghai Cancer CenterAbstract Background Whole-mount histopathology (WMH) has been a powerful tool to investigate the characteristics of prostate cancer. However, the latest advancement of WMH was yet under summarization. In this review, we offer a comprehensive exposition of current research utilizing WMH in diagnosing and treating prostate cancer (PCa), and summarize the clinical advantages of WMH and outlines potential on future prospects. Methods An extensive PubMed search was conducted until February 26, 2023, with the search term “prostate”, “whole-mount”, “large format histology”, which was limited to the last 4 years. Publications included were restricted to those in English. Other papers were also cited to contribute a better understanding. Results WMH exhibits an enhanced legibility for pathologists, which improved the efficacy of pathologic examination and provide educational value. It simplifies the histopathological registration with medical images, which serves as a convincing reference standard for imaging indicator investigation and medical image-based artificial intelligence (AI). Additionally, WMH provides comprehensive histopathological information for tumor volume estimation, post-treatment evaluation, and provides direct pathological data for AI readers. It also offers complete spatial context for the location estimation of both intraprostatic and extraprostatic cancerous region. Conclusions WMH provides unique benefits in several aspects of clinical diagnosis and treatment of PCa. The utilization of WMH technique facilitates the development and refinement of various clinical technologies. We believe that WMH will play an important role in future clinical applications.https://doi.org/10.1186/s12885-024-12071-6Whole-mount histopathologyProstate cancerMRIAIHistopathology |
| spellingShingle | Lewei Duan Zheng Liu Fangning Wan Bo Dai Advantage of whole-mount histopathology in prostate cancer: current applications and future prospects BMC Cancer Whole-mount histopathology Prostate cancer MRI AI Histopathology |
| title | Advantage of whole-mount histopathology in prostate cancer: current applications and future prospects |
| title_full | Advantage of whole-mount histopathology in prostate cancer: current applications and future prospects |
| title_fullStr | Advantage of whole-mount histopathology in prostate cancer: current applications and future prospects |
| title_full_unstemmed | Advantage of whole-mount histopathology in prostate cancer: current applications and future prospects |
| title_short | Advantage of whole-mount histopathology in prostate cancer: current applications and future prospects |
| title_sort | advantage of whole mount histopathology in prostate cancer current applications and future prospects |
| topic | Whole-mount histopathology Prostate cancer MRI AI Histopathology |
| url | https://doi.org/10.1186/s12885-024-12071-6 |
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