Is There Any Effect of Change in Pre-Wash and Post-Wash Semen Parameters on the Success of Intrauterine Insemination?
(1) Background: We aimed to investigate the effect of change in pre-wash and post-wash semen parameters on intrauterine insemination (IUI) success in a homogenous study group. (2) Methods: IUI cycles conducted at an infertility clinic were included in this study. Patient records were examined retros...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/14/1/43 |
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| author | Ali Yavuzcan Engin Yurtçu Betül Keyif Şeyma Osmanlıoğlu |
| author_facet | Ali Yavuzcan Engin Yurtçu Betül Keyif Şeyma Osmanlıoğlu |
| author_sort | Ali Yavuzcan |
| collection | DOAJ |
| description | (1) Background: We aimed to investigate the effect of change in pre-wash and post-wash semen parameters on intrauterine insemination (IUI) success in a homogenous study group. (2) Methods: IUI cycles conducted at an infertility clinic were included in this study. Patient records were examined retrospectively. Δ sperm count (per mL) was calculated as [pre-wash sperm count (per mL)–post-wash sperm count (per mL)]. Δ Total progressive motile sperm count (TPMSC) was also calculated as (post-wash TPMSC-pre-wash TPMSC). (3) Results: No statistically significant difference was detected in terms of Δ sperm count (<i>p</i> = 0.38), and Δ TPMSC (<i>p</i> = 0.76) regarding the clinical pregnancy rate (CPR). There was no statistically significant difference between CPR (+) and CPR (−) groups in terms of post-wash sperm count, TPMSC, TPMSC ≥ 10 × 10⁶, TPMSC ≥ 5 × 10⁶ (<i>p</i> = 0.65, <i>p</i> = 0.79, <i>p</i> = 0.49, <i>p</i> = 0.49, respectively). The live birth rate (LBR) showed no statistically significant differences except for a pre-wash TPMSC ≥ 10 × 10⁶ (<i>p</i> = 0.02). Through the performed ROC analysis, no statistically significant cutoff value could be set for the pre-wash TPMSC. (4) Conclusions: There is only a pre-wash TPMSC ≥ 10 × 10⁶ that showed a significant role in the success of IUI, even when considering all other pre-wash and post-wash semen parameters. Δ sperm count and Δ are not useful markers for IUI success. |
| first_indexed | 2024-03-08T10:45:02Z |
| format | Article |
| id | doaj.art-1dd449791d42471392be775ebee0ee21 |
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| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-08T10:45:02Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-1dd449791d42471392be775ebee0ee212024-01-26T17:19:22ZengMDPI AGJournal of Personalized Medicine2075-44262023-12-011414310.3390/jpm14010043Is There Any Effect of Change in Pre-Wash and Post-Wash Semen Parameters on the Success of Intrauterine Insemination?Ali Yavuzcan0Engin Yurtçu1Betül Keyif2Şeyma Osmanlıoğlu3Department of Obstetrics and Gynecology, Sağlık Bilimleri University, Ankara 06010, TürkiyeDepartment of Obstetrics and Gynecology, Düzce University, Düzce 81620, TürkiyeDepartment of Obstetrics and Gynecology, Düzce University, Düzce 81620, TürkiyeDepartment of Obstetrics and Gynecology, Ankara Medipol University, Ankara 06050, Türkiye(1) Background: We aimed to investigate the effect of change in pre-wash and post-wash semen parameters on intrauterine insemination (IUI) success in a homogenous study group. (2) Methods: IUI cycles conducted at an infertility clinic were included in this study. Patient records were examined retrospectively. Δ sperm count (per mL) was calculated as [pre-wash sperm count (per mL)–post-wash sperm count (per mL)]. Δ Total progressive motile sperm count (TPMSC) was also calculated as (post-wash TPMSC-pre-wash TPMSC). (3) Results: No statistically significant difference was detected in terms of Δ sperm count (<i>p</i> = 0.38), and Δ TPMSC (<i>p</i> = 0.76) regarding the clinical pregnancy rate (CPR). There was no statistically significant difference between CPR (+) and CPR (−) groups in terms of post-wash sperm count, TPMSC, TPMSC ≥ 10 × 10⁶, TPMSC ≥ 5 × 10⁶ (<i>p</i> = 0.65, <i>p</i> = 0.79, <i>p</i> = 0.49, <i>p</i> = 0.49, respectively). The live birth rate (LBR) showed no statistically significant differences except for a pre-wash TPMSC ≥ 10 × 10⁶ (<i>p</i> = 0.02). Through the performed ROC analysis, no statistically significant cutoff value could be set for the pre-wash TPMSC. (4) Conclusions: There is only a pre-wash TPMSC ≥ 10 × 10⁶ that showed a significant role in the success of IUI, even when considering all other pre-wash and post-wash semen parameters. Δ sperm count and Δ are not useful markers for IUI success.https://www.mdpi.com/2075-4426/14/1/43intrauterine inseminationpost-washpre-washsemen parameterssuccess |
| spellingShingle | Ali Yavuzcan Engin Yurtçu Betül Keyif Şeyma Osmanlıoğlu Is There Any Effect of Change in Pre-Wash and Post-Wash Semen Parameters on the Success of Intrauterine Insemination? Journal of Personalized Medicine intrauterine insemination post-wash pre-wash semen parameters success |
| title | Is There Any Effect of Change in Pre-Wash and Post-Wash Semen Parameters on the Success of Intrauterine Insemination? |
| title_full | Is There Any Effect of Change in Pre-Wash and Post-Wash Semen Parameters on the Success of Intrauterine Insemination? |
| title_fullStr | Is There Any Effect of Change in Pre-Wash and Post-Wash Semen Parameters on the Success of Intrauterine Insemination? |
| title_full_unstemmed | Is There Any Effect of Change in Pre-Wash and Post-Wash Semen Parameters on the Success of Intrauterine Insemination? |
| title_short | Is There Any Effect of Change in Pre-Wash and Post-Wash Semen Parameters on the Success of Intrauterine Insemination? |
| title_sort | is there any effect of change in pre wash and post wash semen parameters on the success of intrauterine insemination |
| topic | intrauterine insemination post-wash pre-wash semen parameters success |
| url | https://www.mdpi.com/2075-4426/14/1/43 |
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