Perioperative beta-blocker and its effect on coronary artery bypass graft patients outcome after surgery
Abstract Background Beta-adrenergic receptor blockers have been studied for minimizing the effects of catecholamines by blocking their activation of beta receptors. They are used to prevent or treat hypertensive crises, tachycardia, ischemic cardiomyopathy, and arrhythmias. Several studies have show...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-08-01
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| Series: | Ain Shams Journal of Anesthesiology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s42077-020-00079-6 |
| _version_ | 1819157953895202816 |
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| author | Mohamed N. Elshafei Wael Reda Hussein Oliver M. Shehata Mohamed A. Tolba |
| author_facet | Mohamed N. Elshafei Wael Reda Hussein Oliver M. Shehata Mohamed A. Tolba |
| author_sort | Mohamed N. Elshafei |
| collection | DOAJ |
| description | Abstract Background Beta-adrenergic receptor blockers have been studied for minimizing the effects of catecholamines by blocking their activation of beta receptors. They are used to prevent or treat hypertensive crises, tachycardia, ischemic cardiomyopathy, and arrhythmias. Several studies have shown the efficacy of such drugs in decreasing postoperative morbidity and mortality. Aim of the study This study aimed to evaluate the benefit of perioperative beta-blocker therapy in improving the outcome of CABG surgery regarding intra- and postoperative arrhythmias and ventricular function. Method It was a prospective controlled nonrandomized study conducted on 50 patients undergoing elective CABG in Ain Shams University hospitals, in which the study group, who were the patients who were compliant on beta-blocker therapy, received 1 mg of propranolol before removal of aortic cross clamp and continued on beta-blocker therapy in the postoperative period, while the control group who were not on beta-blocker therapy received an equivalent volume of normal saline before removal of aortic cross clamp and received beta-blocker therapy in the postoperative period. Both groups were assessed regarding the heart rate, ventricular systolic function by transesophageal echo intraoperatively and transthoracic echo postoperatively, duration of ICU and hospital stay, and incidence of intra- and postoperative arrhythmias. Results Perioperative beta-blockers decreased the incidence of intra- and postoperative arrhythmias. Conclusion In the absence of contraindications, CABG patients should receive perioperative beta-blockers as they improve the systolic ventricular function, decrease the incidence of intra- and postoperative arrhythmias, and shorten the duration of hospital and ICU stay. |
| first_indexed | 2024-12-22T16:16:58Z |
| format | Article |
| id | doaj.art-1dd523499d574f968f34d80187cb3924 |
| institution | Directory Open Access Journal |
| issn | 2090-925X |
| language | English |
| last_indexed | 2024-12-22T16:16:58Z |
| publishDate | 2020-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Ain Shams Journal of Anesthesiology |
| spelling | doaj.art-1dd523499d574f968f34d80187cb39242022-12-21T18:20:21ZengSpringerOpenAin Shams Journal of Anesthesiology2090-925X2020-08-011211710.1186/s42077-020-00079-6Perioperative beta-blocker and its effect on coronary artery bypass graft patients outcome after surgeryMohamed N. Elshafei0Wael Reda Hussein1Oliver M. Shehata2Mohamed A. Tolba3Department of Anesthesiology, Intensive care and Pain Management, Faculty of Medicine, Ain-Shams UniversityDepartment of Anesthesiology, Intensive care and Pain Management, Faculty of Medicine, Ain-Shams UniversityDepartment of Anesthesiology, Intensive care and Pain Management, Faculty of Medicine, Ain-Shams UniversityDepartment of Anesthesiology, Intensive care and Pain Management, Faculty of Medicine, Ain-Shams UniversityAbstract Background Beta-adrenergic receptor blockers have been studied for minimizing the effects of catecholamines by blocking their activation of beta receptors. They are used to prevent or treat hypertensive crises, tachycardia, ischemic cardiomyopathy, and arrhythmias. Several studies have shown the efficacy of such drugs in decreasing postoperative morbidity and mortality. Aim of the study This study aimed to evaluate the benefit of perioperative beta-blocker therapy in improving the outcome of CABG surgery regarding intra- and postoperative arrhythmias and ventricular function. Method It was a prospective controlled nonrandomized study conducted on 50 patients undergoing elective CABG in Ain Shams University hospitals, in which the study group, who were the patients who were compliant on beta-blocker therapy, received 1 mg of propranolol before removal of aortic cross clamp and continued on beta-blocker therapy in the postoperative period, while the control group who were not on beta-blocker therapy received an equivalent volume of normal saline before removal of aortic cross clamp and received beta-blocker therapy in the postoperative period. Both groups were assessed regarding the heart rate, ventricular systolic function by transesophageal echo intraoperatively and transthoracic echo postoperatively, duration of ICU and hospital stay, and incidence of intra- and postoperative arrhythmias. Results Perioperative beta-blockers decreased the incidence of intra- and postoperative arrhythmias. Conclusion In the absence of contraindications, CABG patients should receive perioperative beta-blockers as they improve the systolic ventricular function, decrease the incidence of intra- and postoperative arrhythmias, and shorten the duration of hospital and ICU stay.http://link.springer.com/article/10.1186/s42077-020-00079-6Beta-blockersPropranololCoronary artery bypass surgery |
| spellingShingle | Mohamed N. Elshafei Wael Reda Hussein Oliver M. Shehata Mohamed A. Tolba Perioperative beta-blocker and its effect on coronary artery bypass graft patients outcome after surgery Ain Shams Journal of Anesthesiology Beta-blockers Propranolol Coronary artery bypass surgery |
| title | Perioperative beta-blocker and its effect on coronary artery bypass graft patients outcome after surgery |
| title_full | Perioperative beta-blocker and its effect on coronary artery bypass graft patients outcome after surgery |
| title_fullStr | Perioperative beta-blocker and its effect on coronary artery bypass graft patients outcome after surgery |
| title_full_unstemmed | Perioperative beta-blocker and its effect on coronary artery bypass graft patients outcome after surgery |
| title_short | Perioperative beta-blocker and its effect on coronary artery bypass graft patients outcome after surgery |
| title_sort | perioperative beta blocker and its effect on coronary artery bypass graft patients outcome after surgery |
| topic | Beta-blockers Propranolol Coronary artery bypass surgery |
| url | http://link.springer.com/article/10.1186/s42077-020-00079-6 |
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