Asaronic Acid Inhibited Glucose-Triggered M2-Phenotype Shift Through Disrupting the Formation of Coordinated Signaling of IL-4Rα-Tyk2-STAT6 and GLUT1-Akt-mTOR-AMPK

Asaronic Acid Inhibited Glucose-Triggered M2-Phenotype Shift Through Disrupting the Formation of Coordinated Signaling of IL-4Rα-Tyk2-STAT6 and GLUT1-Akt-mTOR-AMPK

Macrophage polarization has been implicated in the pathogenesis of metabolic diseases such as obesity, diabetes, and atherosclerosis. Macrophages responsiveness to polarizing signals can result in their functional phenotype shifts. This study examined whether high glucose induced the functional tran...

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Bibliographic Details
Main Authors: Hyeongjoo Oh, Sin-Hye Park, Min-Kyung Kang, Yun-Ho Kim, Eun-Jung Lee, Dong Yeon Kim, Soo-Il Kim, Su Yeon Oh, Woojin Na, Soon Sung Lim, Young-Hee Kang
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Nutrients
Subjects:
asaronic acid
diabetes
glucose
interleukin-4
M2 macrophage
mTOR
Online Access:https://www.mdpi.com/2072-6643/12/7/2006

Internet

https://www.mdpi.com/2072-6643/12/7/2006

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