Multicomponent Non-Woven Fibrous Mats with Balanced Processing and Functional Properties
The mimicking of the architectonics of native tissue, biodegradable non-woven fibrous mats is one of the most promising forms of scaffolding for tissue engineering. The key properties needed for their successful application in vivo, such as biodegradability, biocompatibility, morphology, mechanical...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/12/9/1911 |
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| author | Tatiana S. Demina Anastasia S. Kuryanova Polina Y. Bikmulina Nadejda A. Aksenova Yuri M. Efremov Zulfar I. Khaibullin Pavel L. Ivanov Nastasia V. Kosheleva Peter S. Timashev Tatiana A. Akopova |
| author_facet | Tatiana S. Demina Anastasia S. Kuryanova Polina Y. Bikmulina Nadejda A. Aksenova Yuri M. Efremov Zulfar I. Khaibullin Pavel L. Ivanov Nastasia V. Kosheleva Peter S. Timashev Tatiana A. Akopova |
| author_sort | Tatiana S. Demina |
| collection | DOAJ |
| description | The mimicking of the architectonics of native tissue, biodegradable non-woven fibrous mats is one of the most promising forms of scaffolding for tissue engineering. The key properties needed for their successful application in vivo, such as biodegradability, biocompatibility, morphology, mechanical properties, etc., rely on their composition and appropriate 3D structure. A multicomponent system based on biodegradable synthetic (polycaprolactone, oligo-/polylactide) and natural (chitosan, gelatin) polymers, providing the desired processing characteristics and functionality to non-woven mats fabricated via the electrospinning technique, was developed. The solid-state reactive blending of these components provided a one-step synthesis of amphiphilic graft copolymer with an ability to form stable ultra-fine dispersions in chlorinated solvents, which could be successfully used as casting solvents for the electrospinning technique. The synthesized graft copolymer was analyzed with the aim of fractional analysis, dynamic laser scattering, FTIR-spectroscopy and DSC. Casting solution characteristics, namely viscosity, surface tension, and electroconductivity, as well as electrospinning parameters, were studied and optimized. The morphology, chemical structure of the surface layer, mechanical properties and cytocompatibility were analyzed to confirm the appropriate functionality of the formed fibrous materials as scaffolds for tissue engineering. |
| first_indexed | 2024-03-10T16:52:40Z |
| format | Article |
| id | doaj.art-1dd8421d398c42148ef4d6409fc37142 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T16:52:40Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-1dd8421d398c42148ef4d6409fc371422023-11-20T11:15:10ZengMDPI AGPolymers2073-43602020-08-01129191110.3390/polym12091911Multicomponent Non-Woven Fibrous Mats with Balanced Processing and Functional PropertiesTatiana S. Demina0Anastasia S. Kuryanova1Polina Y. Bikmulina2Nadejda A. Aksenova3Yuri M. Efremov4Zulfar I. Khaibullin5Pavel L. Ivanov6Nastasia V. Kosheleva7Peter S. Timashev8Tatiana A. Akopova9Enikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences (ISPM RAS), 70 Profsoyuznaya st., 117393 Moscow, RussiaInstitute for Regenerative Medicine, Sechenov University, 8-2 Trubetskaya st., 119991 Moscow, RussiaInstitute for Regenerative Medicine, Sechenov University, 8-2 Trubetskaya st., 119991 Moscow, RussiaInstitute for Regenerative Medicine, Sechenov University, 8-2 Trubetskaya st., 119991 Moscow, RussiaInstitute for Regenerative Medicine, Sechenov University, 8-2 Trubetskaya st., 119991 Moscow, RussiaEnikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences (ISPM RAS), 70 Profsoyuznaya st., 117393 Moscow, RussiaEnikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences (ISPM RAS), 70 Profsoyuznaya st., 117393 Moscow, RussiaFaculty of Biology, Lomonosov Moscow State University, 12-1, Leninskie Gory, 119234 Moscow, RussiaInstitute for Regenerative Medicine, Sechenov University, 8-2 Trubetskaya st., 119991 Moscow, RussiaEnikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences (ISPM RAS), 70 Profsoyuznaya st., 117393 Moscow, RussiaThe mimicking of the architectonics of native tissue, biodegradable non-woven fibrous mats is one of the most promising forms of scaffolding for tissue engineering. The key properties needed for their successful application in vivo, such as biodegradability, biocompatibility, morphology, mechanical properties, etc., rely on their composition and appropriate 3D structure. A multicomponent system based on biodegradable synthetic (polycaprolactone, oligo-/polylactide) and natural (chitosan, gelatin) polymers, providing the desired processing characteristics and functionality to non-woven mats fabricated via the electrospinning technique, was developed. The solid-state reactive blending of these components provided a one-step synthesis of amphiphilic graft copolymer with an ability to form stable ultra-fine dispersions in chlorinated solvents, which could be successfully used as casting solvents for the electrospinning technique. The synthesized graft copolymer was analyzed with the aim of fractional analysis, dynamic laser scattering, FTIR-spectroscopy and DSC. Casting solution characteristics, namely viscosity, surface tension, and electroconductivity, as well as electrospinning parameters, were studied and optimized. The morphology, chemical structure of the surface layer, mechanical properties and cytocompatibility were analyzed to confirm the appropriate functionality of the formed fibrous materials as scaffolds for tissue engineering.https://www.mdpi.com/2073-4360/12/9/1911polyestersgelatinchitosansolvent-free co-extrusionnon-woven matselectrospinning |
| spellingShingle | Tatiana S. Demina Anastasia S. Kuryanova Polina Y. Bikmulina Nadejda A. Aksenova Yuri M. Efremov Zulfar I. Khaibullin Pavel L. Ivanov Nastasia V. Kosheleva Peter S. Timashev Tatiana A. Akopova Multicomponent Non-Woven Fibrous Mats with Balanced Processing and Functional Properties Polymers polyesters gelatin chitosan solvent-free co-extrusion non-woven mats electrospinning |
| title | Multicomponent Non-Woven Fibrous Mats with Balanced Processing and Functional Properties |
| title_full | Multicomponent Non-Woven Fibrous Mats with Balanced Processing and Functional Properties |
| title_fullStr | Multicomponent Non-Woven Fibrous Mats with Balanced Processing and Functional Properties |
| title_full_unstemmed | Multicomponent Non-Woven Fibrous Mats with Balanced Processing and Functional Properties |
| title_short | Multicomponent Non-Woven Fibrous Mats with Balanced Processing and Functional Properties |
| title_sort | multicomponent non woven fibrous mats with balanced processing and functional properties |
| topic | polyesters gelatin chitosan solvent-free co-extrusion non-woven mats electrospinning |
| url | https://www.mdpi.com/2073-4360/12/9/1911 |
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