New strategy of color and power doppler sonography combined with DMSA in the assessment of acute pyelonephritis in infants
Abstract Background The purpose of this study was to evaluate the clinical value of color and power doppler sonography (CPDS) when combined it with 99mTc-dimercaptosuccinic acid scintigraphy (DMSA) in assessment of acute pyelonephritis (APN) in infants. Methods A total of 79 children with APN admitt...
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| Format: | Article |
| Language: | English |
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BMC
2021-05-01
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| Series: | BMC Nephrology |
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| Online Access: | https://doi.org/10.1186/s12882-021-02390-2 |
| _version_ | 1818607082955341824 |
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| author | Min Guang Chen Yan Yang Qing Yang Jie Qiu Zhuang Xiao Hua Ye Wen Jie Zheng |
| author_facet | Min Guang Chen Yan Yang Qing Yang Jie Qiu Zhuang Xiao Hua Ye Wen Jie Zheng |
| author_sort | Min Guang Chen |
| collection | DOAJ |
| description | Abstract Background The purpose of this study was to evaluate the clinical value of color and power doppler sonography (CPDS) when combined it with 99mTc-dimercaptosuccinic acid scintigraphy (DMSA) in assessment of acute pyelonephritis (APN) in infants. Methods A total of 79 children with APN admitted to our hospital from June 2016 to Jan 2019 were enrolled, including 52 boys and 27 girls, age range 1 month to 3 years old. All cases followed the diagnostic criteria for acute pyelonephritis and excluded anatomical abnormalities of urinary system. All 79 patients were examined by urinary ultrasonography (US), CPDS, and DMSA within 48 h of fever and analyzed the clinical value of combining the two methods in the assessment of APN in infants. Results Among 79 children, urinary ultrasonography revealed 2 cases of renal cortical echo changes, both located in the upper pole of the kidney, 24 cases of kidney enlargement, and 1 case of left kidney shrinkage. Ninety-five kidneys were shown to be diseased with DMSA, while 105 kidneys abnormal by CPDS. The sensitivity of CPDS was 69.4%, and the specificity was 38.1%. In children younger than 6 months, the sensitivity of CPDS was 56.9%, which was 84.2% in childeren between 6 months to 1 year, and 94.4% from 1 to 3 years old, respectively. The corresponding specificity of CPDS was 44.1, 26.7, and 35.7%. There was no significant correlation between CPDS levels and DMSA positive results. The abnormal rate of intermediate part in the kidneys was significantly lower than that in the upper and lower poles. Children with abnormal CPDS have a greater risk of renal scarring(p < 0.05). Conclusion Abnormalities detected by CPDS in a cohort of infants with APN poorly correlated with DMSA findings. But the sensitivity of CPDS is highly age-related, it can be used as a non-invasive helpful tool for early diagnosis of acute pyelonephritis in infants older than 6 months old. |
| first_indexed | 2024-12-16T14:21:06Z |
| format | Article |
| id | doaj.art-1dd943f04f064844b8643375870d030c |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-16T14:21:06Z |
| publishDate | 2021-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-1dd943f04f064844b8643375870d030c2022-12-21T22:28:29ZengBMCBMC Nephrology1471-23692021-05-012211610.1186/s12882-021-02390-2New strategy of color and power doppler sonography combined with DMSA in the assessment of acute pyelonephritis in infantsMin Guang Chen0Yan Yang1Qing Yang2Jie Qiu Zhuang3Xiao Hua Ye4Wen Jie Zheng5Department of Nephrology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Ultrasonics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Nephrology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Nephrology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Rheumatology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Rheumatology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityAbstract Background The purpose of this study was to evaluate the clinical value of color and power doppler sonography (CPDS) when combined it with 99mTc-dimercaptosuccinic acid scintigraphy (DMSA) in assessment of acute pyelonephritis (APN) in infants. Methods A total of 79 children with APN admitted to our hospital from June 2016 to Jan 2019 were enrolled, including 52 boys and 27 girls, age range 1 month to 3 years old. All cases followed the diagnostic criteria for acute pyelonephritis and excluded anatomical abnormalities of urinary system. All 79 patients were examined by urinary ultrasonography (US), CPDS, and DMSA within 48 h of fever and analyzed the clinical value of combining the two methods in the assessment of APN in infants. Results Among 79 children, urinary ultrasonography revealed 2 cases of renal cortical echo changes, both located in the upper pole of the kidney, 24 cases of kidney enlargement, and 1 case of left kidney shrinkage. Ninety-five kidneys were shown to be diseased with DMSA, while 105 kidneys abnormal by CPDS. The sensitivity of CPDS was 69.4%, and the specificity was 38.1%. In children younger than 6 months, the sensitivity of CPDS was 56.9%, which was 84.2% in childeren between 6 months to 1 year, and 94.4% from 1 to 3 years old, respectively. The corresponding specificity of CPDS was 44.1, 26.7, and 35.7%. There was no significant correlation between CPDS levels and DMSA positive results. The abnormal rate of intermediate part in the kidneys was significantly lower than that in the upper and lower poles. Children with abnormal CPDS have a greater risk of renal scarring(p < 0.05). Conclusion Abnormalities detected by CPDS in a cohort of infants with APN poorly correlated with DMSA findings. But the sensitivity of CPDS is highly age-related, it can be used as a non-invasive helpful tool for early diagnosis of acute pyelonephritis in infants older than 6 months old.https://doi.org/10.1186/s12882-021-02390-2Color and power doppler sonography99mTc-dimercaptosuccinic acid scintigraphyAcute pyelonephritisChildrenKidney |
| spellingShingle | Min Guang Chen Yan Yang Qing Yang Jie Qiu Zhuang Xiao Hua Ye Wen Jie Zheng New strategy of color and power doppler sonography combined with DMSA in the assessment of acute pyelonephritis in infants BMC Nephrology Color and power doppler sonography 99mTc-dimercaptosuccinic acid scintigraphy Acute pyelonephritis Children Kidney |
| title | New strategy of color and power doppler sonography combined with DMSA in the assessment of acute pyelonephritis in infants |
| title_full | New strategy of color and power doppler sonography combined with DMSA in the assessment of acute pyelonephritis in infants |
| title_fullStr | New strategy of color and power doppler sonography combined with DMSA in the assessment of acute pyelonephritis in infants |
| title_full_unstemmed | New strategy of color and power doppler sonography combined with DMSA in the assessment of acute pyelonephritis in infants |
| title_short | New strategy of color and power doppler sonography combined with DMSA in the assessment of acute pyelonephritis in infants |
| title_sort | new strategy of color and power doppler sonography combined with dmsa in the assessment of acute pyelonephritis in infants |
| topic | Color and power doppler sonography 99mTc-dimercaptosuccinic acid scintigraphy Acute pyelonephritis Children Kidney |
| url | https://doi.org/10.1186/s12882-021-02390-2 |
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