Childhood socioeconomic position and sex-specific trajectories of metabolic traits across early life: prospective cohort studyResearch in context
Summary: Background: Socioeconomic inequalities in cardiovascular disease risk begin early in life and are more pronounced in females than males later in life. Causal atherogenic traits explaining this are not well understood. We explored sex-specific associations between childhood socioeconomic po...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | EBioMedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396423004504 |
| _version_ | 1827686985738747904 |
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| author | Kate N. O'Neill Joshua A. Bell George Davey Smith Abigail Fraser Laura D. Howe Patricia M. Kearney Oliver Robinson Kate Tilling Peter Willeit Linda M. O'Keeffe |
| author_facet | Kate N. O'Neill Joshua A. Bell George Davey Smith Abigail Fraser Laura D. Howe Patricia M. Kearney Oliver Robinson Kate Tilling Peter Willeit Linda M. O'Keeffe |
| author_sort | Kate N. O'Neill |
| collection | DOAJ |
| description | Summary: Background: Socioeconomic inequalities in cardiovascular disease risk begin early in life and are more pronounced in females than males later in life. Causal atherogenic traits explaining this are not well understood. We explored sex-specific associations between childhood socioeconomic position (SEP) and molecular measures of systemic metabolism across early life. Methods: Data were from the Avon Longitudinal Study of Parents and Children (ALSPAC), a population-based birth cohort in southwest England. Pregnant women with an expected delivery date between 1991 and 1992 were invited to participate. Maternal education was the primary indicator of SEP. Concentrations of 148 metabolic traits from targeted metabolomics (nuclear magnetic resonance spectroscopy) from research clinics at ages 7, 15, 18 and 25 years were analysed. The sex-specific slope index of inequality (SII) in trajectories of metabolic traits was estimated using multilevel models. Findings: Total number of participants included was 6537 (12,543 repeated measures). Lower maternal education was associated with more adverse levels of several atherogenic lipids and key metabolic traits among females at age 7 years, but not males. For instance, SII for very small very-low-density lipoprotein (VLDL) concentrations was 0.16SD (95% CI: 0.01, 0.30) among females and −0.02SD (95% CI: −0.16, 0.13) among males. Between 7 and 25 years, inequalities widened among females and emerged among males particularly for VLDL particle concentrations, apolipoprotein-B concentrations, and inflammatory glycoprotein acetyls. For instance, at 25 years, SII for very small VLDL concentrations was 0.36SD (95% CI: 0.20, 0.52) and 0.22SD (95% CI: 0.04, 0.40) among females and males respectively. Interpretation: Prevention of socioeconomic inequalities in cardiovascular disease risk requires a life course approach beginning at the earliest opportunity, especially among females. Funding: The UK Medical Research Council and Wellcome (grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. A comprehensive list of grants funding is available on the ALSPAC website (http://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf). KON is supported by a Health Research Board (HRB) of Ireland Investigator Led Award (ILP-PHR-2022-008). JB, GDS and KT work in a unit funded by the UK MRC (MC_UU_00011/1 and MC UU 00011/3) and the University of Bristol. OR is supported by a UKRI Future Leaders Fellowship (MR/S03532X/1). These funding sources had no role in the design and conduct of this study. This publication is the work of the authors and KON will serve as guarantor for the contents of this paper. |
| first_indexed | 2024-03-10T09:26:20Z |
| format | Article |
| id | doaj.art-1dd9abd53ba342e580da35b0fecac055 |
| institution | Directory Open Access Journal |
| issn | 2352-3964 |
| language | English |
| last_indexed | 2024-03-10T09:26:20Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj.art-1dd9abd53ba342e580da35b0fecac0552023-11-22T04:47:45ZengElsevierEBioMedicine2352-39642023-12-0198104884Childhood socioeconomic position and sex-specific trajectories of metabolic traits across early life: prospective cohort studyResearch in contextKate N. O'Neill0Joshua A. Bell1George Davey Smith2Abigail Fraser3Laura D. Howe4Patricia M. Kearney5Oliver Robinson6Kate Tilling7Peter Willeit8Linda M. O'Keeffe9School of Public Health, Western Gateway Building, University College Cork, Cork, Ireland; Corresponding author. School of Public Health, University College Cork, Western Gateway Building, Ireland.MRC Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS82BN, UK; Population Health Sciences, Bristol Medical School, Oakfield House, Oakfield Grove, Bristol, BS82BN, UKMRC Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS82BN, UK; Population Health Sciences, Bristol Medical School, Oakfield House, Oakfield Grove, Bristol, BS82BN, UKMRC Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS82BN, UK; Population Health Sciences, Bristol Medical School, Oakfield House, Oakfield Grove, Bristol, BS82BN, UKMRC Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS82BN, UK; Population Health Sciences, Bristol Medical School, Oakfield House, Oakfield Grove, Bristol, BS82BN, UKSchool of Public Health, Western Gateway Building, University College Cork, Cork, IrelandMRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UKMRC Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS82BN, UK; Population Health Sciences, Bristol Medical School, Oakfield House, Oakfield Grove, Bristol, BS82BN, UKClinical Epidemiology Team, Medical University of Innsbruck, Austria; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UKSchool of Public Health, Western Gateway Building, University College Cork, Cork, Ireland; MRC Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS82BN, UK; Population Health Sciences, Bristol Medical School, Oakfield House, Oakfield Grove, Bristol, BS82BN, UKSummary: Background: Socioeconomic inequalities in cardiovascular disease risk begin early in life and are more pronounced in females than males later in life. Causal atherogenic traits explaining this are not well understood. We explored sex-specific associations between childhood socioeconomic position (SEP) and molecular measures of systemic metabolism across early life. Methods: Data were from the Avon Longitudinal Study of Parents and Children (ALSPAC), a population-based birth cohort in southwest England. Pregnant women with an expected delivery date between 1991 and 1992 were invited to participate. Maternal education was the primary indicator of SEP. Concentrations of 148 metabolic traits from targeted metabolomics (nuclear magnetic resonance spectroscopy) from research clinics at ages 7, 15, 18 and 25 years were analysed. The sex-specific slope index of inequality (SII) in trajectories of metabolic traits was estimated using multilevel models. Findings: Total number of participants included was 6537 (12,543 repeated measures). Lower maternal education was associated with more adverse levels of several atherogenic lipids and key metabolic traits among females at age 7 years, but not males. For instance, SII for very small very-low-density lipoprotein (VLDL) concentrations was 0.16SD (95% CI: 0.01, 0.30) among females and −0.02SD (95% CI: −0.16, 0.13) among males. Between 7 and 25 years, inequalities widened among females and emerged among males particularly for VLDL particle concentrations, apolipoprotein-B concentrations, and inflammatory glycoprotein acetyls. For instance, at 25 years, SII for very small VLDL concentrations was 0.36SD (95% CI: 0.20, 0.52) and 0.22SD (95% CI: 0.04, 0.40) among females and males respectively. Interpretation: Prevention of socioeconomic inequalities in cardiovascular disease risk requires a life course approach beginning at the earliest opportunity, especially among females. Funding: The UK Medical Research Council and Wellcome (grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. A comprehensive list of grants funding is available on the ALSPAC website (http://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf). KON is supported by a Health Research Board (HRB) of Ireland Investigator Led Award (ILP-PHR-2022-008). JB, GDS and KT work in a unit funded by the UK MRC (MC_UU_00011/1 and MC UU 00011/3) and the University of Bristol. OR is supported by a UKRI Future Leaders Fellowship (MR/S03532X/1). These funding sources had no role in the design and conduct of this study. This publication is the work of the authors and KON will serve as guarantor for the contents of this paper.http://www.sciencedirect.com/science/article/pii/S2352396423004504ALSPACSocioeconomic inequalitiesCardiovascular disease |
| spellingShingle | Kate N. O'Neill Joshua A. Bell George Davey Smith Abigail Fraser Laura D. Howe Patricia M. Kearney Oliver Robinson Kate Tilling Peter Willeit Linda M. O'Keeffe Childhood socioeconomic position and sex-specific trajectories of metabolic traits across early life: prospective cohort studyResearch in context EBioMedicine ALSPAC Socioeconomic inequalities Cardiovascular disease |
| title | Childhood socioeconomic position and sex-specific trajectories of metabolic traits across early life: prospective cohort studyResearch in context |
| title_full | Childhood socioeconomic position and sex-specific trajectories of metabolic traits across early life: prospective cohort studyResearch in context |
| title_fullStr | Childhood socioeconomic position and sex-specific trajectories of metabolic traits across early life: prospective cohort studyResearch in context |
| title_full_unstemmed | Childhood socioeconomic position and sex-specific trajectories of metabolic traits across early life: prospective cohort studyResearch in context |
| title_short | Childhood socioeconomic position and sex-specific trajectories of metabolic traits across early life: prospective cohort studyResearch in context |
| title_sort | childhood socioeconomic position and sex specific trajectories of metabolic traits across early life prospective cohort studyresearch in context |
| topic | ALSPAC Socioeconomic inequalities Cardiovascular disease |
| url | http://www.sciencedirect.com/science/article/pii/S2352396423004504 |
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