Structural and functional properties of the Kunitz-type and C-terminal domains of Amblyomin-X supporting its antitumor activity

Structural and functional properties of the Kunitz-type and C-terminal domains of Amblyomin-X supporting its antitumor activity

Amblyomin-X is a Kunitz-type FXa inhibitor identified through the transcriptome analysis of the salivary gland from Amblyomma sculptum tick. This protein consists of two domains of equivalent size, triggers apoptosis in different tumor cell lines, and promotes regression of tumor growth, and reducti...

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Main Authors: K. L. P. Morais, L. Ciccone, E. Stura, M. P. Alvarez-Flores, G. Mourier, M. Vanden Driessche, J. M. Sciani, A. Iqbal, S. P. Kalil, G. J. Pereira, R. Marques-Porto, P. Cunegundes, L. Juliano, D. Servent, A. M. Chudzinski-Tavassi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Molecular Biosciences
Subjects:
antitumor drug candidate
Amblyomin-X
TFPI-like
endocytosis
protein crystallization
high content imaging (HCI)
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1072751/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1072751/full

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