Genome Analysis Using Whole-Exome Sequencing of Non-Syndromic Cleft Lip and/or Palate from Malagasy Trios Identifies Variants Associated with Cilium-Related Pathways and Asian Genetic Ancestry

Genome Analysis Using Whole-Exome Sequencing of Non-Syndromic Cleft Lip and/or Palate from Malagasy Trios Identifies Variants Associated with Cilium-Related Pathways and Asian Genetic Ancestry

Background: Orofacial clefts (OFCs) are common congenital disabilities that can occur as isolated non-syndromic events or as part of Mendelian syndromes. OFC risk factors vary due to differences in regional environmental exposures, genetic variants, and ethnicities. In recent years, significant prog...

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Bibliographic Details
Main Authors: Zarko Manojlovic, Allyn Auslander, Yuxin Jin, Ryan J. Schmidt, Yili Xu, Sharon Chang, Ruocen Song, Sue A. Ingles, Alana Nunes, KC Vavra, Devin Feigelson, Sylvia Rakotoarison, Melissa DiBona, Kathy Magee, Operation Smile, Anjaramamy Ramamonjisoa, William Magee III
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Genes
Subjects:
cleft lip
cleft palate
whole-exome sequencing
genetic ancestry
primary cilia
genetic syndrome
Online Access:https://www.mdpi.com/2073-4425/14/3/665

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