DNA methylation patterns of candidate genes regulated by thymine DNA glycosylase in patients with TP53 germline mutations

DNA methylation patterns of candidate genes regulated by thymine DNA glycosylase in patients with TP53 germline mutations

Li-Fraumeni syndrome (LFS) is a rare, autosomal dominant, hereditary cancer predisposition disorder. In Brazil, the p.R337H TP53 founder mutation causes the variant form of LFS, Li-Fraumeni-like syndrome. The occurrence of cancer and age of disease onset are known to vary, even in patients carrying...

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Bibliographic Details
Main Authors: F.P. Fortes, H. Kuasne, F.A. Marchi, P.M. Miranda, S.R. Rogatto, M.I. Achatz
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2015-07-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Li-Fraumeni syndrome
TP53 gene
TDG
Methylation
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000700610&lng=en&tlng=en

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