Neurokinin receptor antagonists as potential non-hormonal treatments for vasomotor symptoms of menopause
Vasomotor symptoms of menopause (VMS), otherwise known as hot flashes, can significantly impact women’s quality of life. Up to 87% of women report hot flashes during or after their menopause transition, and can last for a median duration of 7.4 years. The current mainstay of treatment and the most e...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-06-01
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| Series: | Therapeutic Advances in Reproductive Health |
| Online Access: | https://doi.org/10.1177/26334941231177611 |
| _version_ | 1797797580346753024 |
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| author | Melissa Conklin Nanette Santoro |
| author_facet | Melissa Conklin Nanette Santoro |
| author_sort | Melissa Conklin |
| collection | DOAJ |
| description | Vasomotor symptoms of menopause (VMS), otherwise known as hot flashes, can significantly impact women’s quality of life. Up to 87% of women report hot flashes during or after their menopause transition, and can last for a median duration of 7.4 years. The current mainstay of treatment and the most effective treatment for VMS is hormone therapy with estrogen. However, hormone therapy is not without risk, and the discovery of an effective nonhormonal treatment option with neurokinin B receptor antagonists for VMS provides an encouraging and potentially practice-changing treatment option for all women. This review will discuss the pathophysiology and mechanism of action, as well as review the current compounds in development targeting the neurokinin receptors. |
| first_indexed | 2024-03-13T03:50:30Z |
| format | Article |
| id | doaj.art-1dde0f0b3f4d481f8fce0d5a08c4bdd9 |
| institution | Directory Open Access Journal |
| issn | 2633-4941 |
| language | English |
| last_indexed | 2024-03-13T03:50:30Z |
| publishDate | 2023-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Reproductive Health |
| spelling | doaj.art-1dde0f0b3f4d481f8fce0d5a08c4bdd92023-06-22T13:33:24ZengSAGE PublishingTherapeutic Advances in Reproductive Health2633-49412023-06-011710.1177/26334941231177611Neurokinin receptor antagonists as potential non-hormonal treatments for vasomotor symptoms of menopauseMelissa ConklinNanette SantoroVasomotor symptoms of menopause (VMS), otherwise known as hot flashes, can significantly impact women’s quality of life. Up to 87% of women report hot flashes during or after their menopause transition, and can last for a median duration of 7.4 years. The current mainstay of treatment and the most effective treatment for VMS is hormone therapy with estrogen. However, hormone therapy is not without risk, and the discovery of an effective nonhormonal treatment option with neurokinin B receptor antagonists for VMS provides an encouraging and potentially practice-changing treatment option for all women. This review will discuss the pathophysiology and mechanism of action, as well as review the current compounds in development targeting the neurokinin receptors.https://doi.org/10.1177/26334941231177611 |
| spellingShingle | Melissa Conklin Nanette Santoro Neurokinin receptor antagonists as potential non-hormonal treatments for vasomotor symptoms of menopause Therapeutic Advances in Reproductive Health |
| title | Neurokinin receptor antagonists as potential non-hormonal treatments for vasomotor symptoms of menopause |
| title_full | Neurokinin receptor antagonists as potential non-hormonal treatments for vasomotor symptoms of menopause |
| title_fullStr | Neurokinin receptor antagonists as potential non-hormonal treatments for vasomotor symptoms of menopause |
| title_full_unstemmed | Neurokinin receptor antagonists as potential non-hormonal treatments for vasomotor symptoms of menopause |
| title_short | Neurokinin receptor antagonists as potential non-hormonal treatments for vasomotor symptoms of menopause |
| title_sort | neurokinin receptor antagonists as potential non hormonal treatments for vasomotor symptoms of menopause |
| url | https://doi.org/10.1177/26334941231177611 |
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