Perspective: A proposal on solutions of modern supply chain construction for lactoferrin
ABSTRACT: Lactoferrin is an iron-binding glycoprotein of the transferrin family that is found in most bodily fluids of mammals and has a variety of biological and beneficial functions, with great importance in health enhancement as a supplement for humans and other animals. More than 300 t of lactof...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-11-01
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| Series: | Journal of Dairy Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S002203022300499X |
| _version_ | 1797653938164465664 |
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| author | Ruoyu Mao Xuanxuan Ma Ya Hao Guihong Pen Xueling Zheng Na Yang Da Teng Jianhua Wang |
| author_facet | Ruoyu Mao Xuanxuan Ma Ya Hao Guihong Pen Xueling Zheng Na Yang Da Teng Jianhua Wang |
| author_sort | Ruoyu Mao |
| collection | DOAJ |
| description | ABSTRACT: Lactoferrin is an iron-binding glycoprotein of the transferrin family that is found in most bodily fluids of mammals and has a variety of biological and beneficial functions, with great importance in health enhancement as a supplement for humans and other animals. More than 300 t of lactoferrin were produced in 2021, and this number is expected to grow yearly by 10% to 12%, to over 580 t in 2030. With new and important functions of lactoferrin being revealed and studied, focus on its industrial production and application is increasing accordingly. However, lactoferrin is mainly sourced from cheese whey or skim milk by cation-exchange column chromatography, which is a costly and low-quality method. A potential solution for lactoferrin global supply chain construction is proposed in this article as a complement to traditional routes of purification from whey or skim milk. The large-scale production of lactoferrin, mainly by recombinant yeast, mammal, and grain systems, as well as the market niche and product design, are discussed. |
| first_indexed | 2024-03-11T16:52:06Z |
| format | Article |
| id | doaj.art-1ddfce1119d84ed3ac3750135116aaaa |
| institution | Directory Open Access Journal |
| issn | 0022-0302 |
| language | English |
| last_indexed | 2024-03-11T16:52:06Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Dairy Science |
| spelling | doaj.art-1ddfce1119d84ed3ac3750135116aaaa2023-10-21T04:21:47ZengElsevierJournal of Dairy Science0022-03022023-11-011061173297335Perspective: A proposal on solutions of modern supply chain construction for lactoferrinRuoyu Mao0Xuanxuan Ma1Ya Hao2Guihong Pen3Xueling Zheng4Na Yang5Da Teng6Jianhua Wang7Key Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Beijing 100081, China; Innovative Team of Antimicrobial Peptides and Alternatives to Antibiotics, Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China; R&D Center, Beijing Shengtai Clouds Bio-Technology Inc., Beijing 100081, ChinaKey Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Beijing 100081, China; Innovative Team of Antimicrobial Peptides and Alternatives to Antibiotics, Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinaKey Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Beijing 100081, China; Innovative Team of Antimicrobial Peptides and Alternatives to Antibiotics, Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China; R&D Center, Beijing Shengtai Clouds Bio-Technology Inc., Beijing 100081, ChinaKey Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Beijing 100081, China; Innovative Team of Antimicrobial Peptides and Alternatives to Antibiotics, Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinaKey Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Beijing 100081, China; Innovative Team of Antimicrobial Peptides and Alternatives to Antibiotics, Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinaKey Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Beijing 100081, China; Innovative Team of Antimicrobial Peptides and Alternatives to Antibiotics, Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China; R&D Center, Beijing Shengtai Clouds Bio-Technology Inc., Beijing 100081, ChinaKey Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Beijing 100081, China; Innovative Team of Antimicrobial Peptides and Alternatives to Antibiotics, Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China; R&D Center, Beijing Shengtai Clouds Bio-Technology Inc., Beijing 100081, ChinaKey Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Beijing 100081, China; Innovative Team of Antimicrobial Peptides and Alternatives to Antibiotics, Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China; R&D Center, Beijing Shengtai Clouds Bio-Technology Inc., Beijing 100081, China; Corresponding authorABSTRACT: Lactoferrin is an iron-binding glycoprotein of the transferrin family that is found in most bodily fluids of mammals and has a variety of biological and beneficial functions, with great importance in health enhancement as a supplement for humans and other animals. More than 300 t of lactoferrin were produced in 2021, and this number is expected to grow yearly by 10% to 12%, to over 580 t in 2030. With new and important functions of lactoferrin being revealed and studied, focus on its industrial production and application is increasing accordingly. However, lactoferrin is mainly sourced from cheese whey or skim milk by cation-exchange column chromatography, which is a costly and low-quality method. A potential solution for lactoferrin global supply chain construction is proposed in this article as a complement to traditional routes of purification from whey or skim milk. The large-scale production of lactoferrin, mainly by recombinant yeast, mammal, and grain systems, as well as the market niche and product design, are discussed.http://www.sciencedirect.com/science/article/pii/S002203022300499Xlactoferrinsupply chain constructionniche marketrecombinant expression |
| spellingShingle | Ruoyu Mao Xuanxuan Ma Ya Hao Guihong Pen Xueling Zheng Na Yang Da Teng Jianhua Wang Perspective: A proposal on solutions of modern supply chain construction for lactoferrin Journal of Dairy Science lactoferrin supply chain construction niche market recombinant expression |
| title | Perspective: A proposal on solutions of modern supply chain construction for lactoferrin |
| title_full | Perspective: A proposal on solutions of modern supply chain construction for lactoferrin |
| title_fullStr | Perspective: A proposal on solutions of modern supply chain construction for lactoferrin |
| title_full_unstemmed | Perspective: A proposal on solutions of modern supply chain construction for lactoferrin |
| title_short | Perspective: A proposal on solutions of modern supply chain construction for lactoferrin |
| title_sort | perspective a proposal on solutions of modern supply chain construction for lactoferrin |
| topic | lactoferrin supply chain construction niche market recombinant expression |
| url | http://www.sciencedirect.com/science/article/pii/S002203022300499X |
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