Association of BMI and Age with Gleason Score and PSA in Patients with Prostate Cancer
Background and Objective: Obesity has produced conflicting results on various indices of prostate cancer diagnosis. Since the effect of body mass index (BMI) on Gleason score and prostate specific antigen (PSA) as well as the overall classified risk of prostate cancer results is important, the prese...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2023-03-01
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| Series: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul |
| Subjects: | |
| Online Access: | http://jbums.org/article-1-11663-en.pdf |
| _version_ | 1797374891424481280 |
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| author | SA Mazloumi E Moudi H Shafi H Gholinia |
| author_facet | SA Mazloumi E Moudi H Shafi H Gholinia |
| author_sort | SA Mazloumi |
| collection | DOAJ |
| description | Background and Objective: Obesity has produced conflicting results on various indices of prostate cancer diagnosis. Since the effect of body mass index (BMI) on Gleason score and prostate specific antigen (PSA) as well as the overall classified risk of prostate cancer results is important, the present study was conducted to investigate the association of BMI and age with Gleason score and PSA in Patients with prostate cancer.
Methods: In this cross-sectional study, 310 prostate cancer patients referred to the affiliated hospitals of Babol University of Medical Sciences from 2011 to 2021 were evaluated in terms of age, height, weight, PSA and Gleason score. Based on BMI, the patients were divided into three groups: obese (BMI≥30), overweight (BMI=25-30) and normal weight (BMI<25) and according to the Gleason score into three low grades (G/S<7), medium grade (G/S=7), high grade (G/S>7) and were divided into three categories based on PSA: 4-10, 10-20 and more than 20. Then, the association of BMI and age with Gleason score and PSA was investigated.
Findings: The mean BMI of the patients was 26.3±3.77 kg/m2. The mean PSA was 35.72±8.5 ng/dL and the mean Gleason score was 7.1±1.11. The mean Gleason score increased with increasing age (p<0.001, r=0.307). A higher Gleason score had a significant relationship with PSA increase (p<0.001, r=0.485). BMI had no significant association with Gleason score (r=0.072, p=0.102). PSA decreased slightly with increasing BMI (p=0.006, r=0.157).
Conclusion: The results of the study showed that increasing age is associated with a higher Gleason score. But the increase in BMI is not related to increased risk of prostate cancer and increased Gleason score. |
| first_indexed | 2024-03-08T19:12:19Z |
| format | Article |
| id | doaj.art-1ddfd970de12467d997a9b5d0f6bfd9f |
| institution | Directory Open Access Journal |
| issn | 1561-4107 2251-7170 |
| language | English |
| last_indexed | 2024-03-08T19:12:19Z |
| publishDate | 2023-03-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul |
| spelling | doaj.art-1ddfd970de12467d997a9b5d0f6bfd9f2023-12-27T10:07:40ZengBabol University of Medical SciencesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul1561-41072251-71702023-03-01251455462Association of BMI and Age with Gleason Score and PSA in Patients with Prostate CancerSA Mazloumi0E Moudi1H Shafi2H Gholinia3 1.Student Research Committee, Babol University of Medical Sciences, Babol, I.R.Iran. 2.Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol I.R.Iran. 3.Clinical Research Development Unit of Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, I.R.Iran. 4.Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran. Background and Objective: Obesity has produced conflicting results on various indices of prostate cancer diagnosis. Since the effect of body mass index (BMI) on Gleason score and prostate specific antigen (PSA) as well as the overall classified risk of prostate cancer results is important, the present study was conducted to investigate the association of BMI and age with Gleason score and PSA in Patients with prostate cancer. Methods: In this cross-sectional study, 310 prostate cancer patients referred to the affiliated hospitals of Babol University of Medical Sciences from 2011 to 2021 were evaluated in terms of age, height, weight, PSA and Gleason score. Based on BMI, the patients were divided into three groups: obese (BMI≥30), overweight (BMI=25-30) and normal weight (BMI<25) and according to the Gleason score into three low grades (G/S<7), medium grade (G/S=7), high grade (G/S>7) and were divided into three categories based on PSA: 4-10, 10-20 and more than 20. Then, the association of BMI and age with Gleason score and PSA was investigated. Findings: The mean BMI of the patients was 26.3±3.77 kg/m2. The mean PSA was 35.72±8.5 ng/dL and the mean Gleason score was 7.1±1.11. The mean Gleason score increased with increasing age (p<0.001, r=0.307). A higher Gleason score had a significant relationship with PSA increase (p<0.001, r=0.485). BMI had no significant association with Gleason score (r=0.072, p=0.102). PSA decreased slightly with increasing BMI (p=0.006, r=0.157). Conclusion: The results of the study showed that increasing age is associated with a higher Gleason score. But the increase in BMI is not related to increased risk of prostate cancer and increased Gleason score.http://jbums.org/article-1-11663-en.pdfbody mass indexagegleason scoreprostate specific antigen. |
| spellingShingle | SA Mazloumi E Moudi H Shafi H Gholinia Association of BMI and Age with Gleason Score and PSA in Patients with Prostate Cancer Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul body mass index age gleason score prostate specific antigen. |
| title | Association of BMI and Age with Gleason Score and PSA in Patients with Prostate Cancer |
| title_full | Association of BMI and Age with Gleason Score and PSA in Patients with Prostate Cancer |
| title_fullStr | Association of BMI and Age with Gleason Score and PSA in Patients with Prostate Cancer |
| title_full_unstemmed | Association of BMI and Age with Gleason Score and PSA in Patients with Prostate Cancer |
| title_short | Association of BMI and Age with Gleason Score and PSA in Patients with Prostate Cancer |
| title_sort | association of bmi and age with gleason score and psa in patients with prostate cancer |
| topic | body mass index age gleason score prostate specific antigen. |
| url | http://jbums.org/article-1-11663-en.pdf |
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