Recent Applications of Mixture Designs in Beverages, Foods, and Pharmaceutical Health: A Systematic Review and Meta-Analysis
Design of Experiments (DoE) is a statistical tool used to plan and optimize experiments and is seen as a quality technology to achieve products excellence. Among the experimental designs (EDs), the mixture designs (MDs) stand out, being widely applied to improve conditions for processing, developing...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/10/8/1941 |
| _version_ | 1797523817755574272 |
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| author | Diego Galvan Luciane Effting Hágata Cremasco Carlos Adam Conte-Junior |
| author_facet | Diego Galvan Luciane Effting Hágata Cremasco Carlos Adam Conte-Junior |
| author_sort | Diego Galvan |
| collection | DOAJ |
| description | Design of Experiments (DoE) is a statistical tool used to plan and optimize experiments and is seen as a quality technology to achieve products excellence. Among the experimental designs (EDs), the mixture designs (MDs) stand out, being widely applied to improve conditions for processing, developing, or formulating novel products. This review aims to provide useful updated information on the capacity and diversity of MDs applications for the industry and scientific community in the areas of food, beverage, and pharmaceutical health. Recent works were selected following the Preferred Reporting Items for Systematic Review and Meta-Analyses statement (PRISMA) flow diagram. Data analysis was performed by self-organizing map (SOM) to check and understand which fields of application/countries/continents are using MDs. Overall, the SOM indicated that Brazil presented the largest number of works using MDs. Among the continents, America and Asia showed a predominance in applications with the same amount of work. Comparing the MDs application areas, the analysis indicated that works are prevalent in food and beverage science in the American continent, while in Asia, health science prevails. MDs were more used to develop functional/nutraceutical products and the formulation of drugs for several diseases. However, we briefly describe some promising research fields in that MDs can still be employed. |
| first_indexed | 2024-03-10T08:48:28Z |
| format | Article |
| id | doaj.art-1de20801c1974d85968b9d9011a3d08b |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T08:48:28Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-1de20801c1974d85968b9d9011a3d08b2023-11-22T07:41:06ZengMDPI AGFoods2304-81582021-08-01108194110.3390/foods10081941Recent Applications of Mixture Designs in Beverages, Foods, and Pharmaceutical Health: A Systematic Review and Meta-AnalysisDiego Galvan0Luciane Effting1Hágata Cremasco2Carlos Adam Conte-Junior3Center for Food Analysis (NAL), Technological Development Support Laboratory (LADETEC), Federal University of Rio de Janeiro (UFRJ), Cidade Universitária, Rio de Janeiro 21941-598, RJ, BrazilChemistry Department, State University of Londrina (UEL), Rodovia Celso Garcia Cid (PR 445), Londrina 86057-970, PR, BrazilChemistry Department, State University of Londrina (UEL), Rodovia Celso Garcia Cid (PR 445), Londrina 86057-970, PR, BrazilCenter for Food Analysis (NAL), Technological Development Support Laboratory (LADETEC), Federal University of Rio de Janeiro (UFRJ), Cidade Universitária, Rio de Janeiro 21941-598, RJ, BrazilDesign of Experiments (DoE) is a statistical tool used to plan and optimize experiments and is seen as a quality technology to achieve products excellence. Among the experimental designs (EDs), the mixture designs (MDs) stand out, being widely applied to improve conditions for processing, developing, or formulating novel products. This review aims to provide useful updated information on the capacity and diversity of MDs applications for the industry and scientific community in the areas of food, beverage, and pharmaceutical health. Recent works were selected following the Preferred Reporting Items for Systematic Review and Meta-Analyses statement (PRISMA) flow diagram. Data analysis was performed by self-organizing map (SOM) to check and understand which fields of application/countries/continents are using MDs. Overall, the SOM indicated that Brazil presented the largest number of works using MDs. Among the continents, America and Asia showed a predominance in applications with the same amount of work. Comparing the MDs application areas, the analysis indicated that works are prevalent in food and beverage science in the American continent, while in Asia, health science prevails. MDs were more used to develop functional/nutraceutical products and the formulation of drugs for several diseases. However, we briefly describe some promising research fields in that MDs can still be employed.https://www.mdpi.com/2304-8158/10/8/1941design of experiments (DoE)experimental designs (EDs)mixture designs (MDs)simplex lattice design (SLD)simplex-centroid design (SCD) |
| spellingShingle | Diego Galvan Luciane Effting Hágata Cremasco Carlos Adam Conte-Junior Recent Applications of Mixture Designs in Beverages, Foods, and Pharmaceutical Health: A Systematic Review and Meta-Analysis Foods design of experiments (DoE) experimental designs (EDs) mixture designs (MDs) simplex lattice design (SLD) simplex-centroid design (SCD) |
| title | Recent Applications of Mixture Designs in Beverages, Foods, and Pharmaceutical Health: A Systematic Review and Meta-Analysis |
| title_full | Recent Applications of Mixture Designs in Beverages, Foods, and Pharmaceutical Health: A Systematic Review and Meta-Analysis |
| title_fullStr | Recent Applications of Mixture Designs in Beverages, Foods, and Pharmaceutical Health: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Recent Applications of Mixture Designs in Beverages, Foods, and Pharmaceutical Health: A Systematic Review and Meta-Analysis |
| title_short | Recent Applications of Mixture Designs in Beverages, Foods, and Pharmaceutical Health: A Systematic Review and Meta-Analysis |
| title_sort | recent applications of mixture designs in beverages foods and pharmaceutical health a systematic review and meta analysis |
| topic | design of experiments (DoE) experimental designs (EDs) mixture designs (MDs) simplex lattice design (SLD) simplex-centroid design (SCD) |
| url | https://www.mdpi.com/2304-8158/10/8/1941 |
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