Galectins in Intra- and Extracellular Vesicles
Carbohydrate-binding galectins are expressed in various tissues of multicellular organisms. They are involved in autophagy, cell migration, immune response, inflammation, intracellular transport, and signaling. In recent years, novel roles of galectin-interaction with membrane components have been c...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/10/9/1232 |
| _version_ | 1797555789224738816 |
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| author | Sebastian Bänfer Ralf Jacob |
| author_facet | Sebastian Bänfer Ralf Jacob |
| author_sort | Sebastian Bänfer |
| collection | DOAJ |
| description | Carbohydrate-binding galectins are expressed in various tissues of multicellular organisms. They are involved in autophagy, cell migration, immune response, inflammation, intracellular transport, and signaling. In recent years, novel roles of galectin-interaction with membrane components have been characterized, which lead to the formation of vesicles with diverse functions. These vesicles are part of intracellular transport pathways, belong to the cellular degradation machinery, or can be released for cell-to-cell communication. Several characteristics of galectins in the lumen or at the membrane of newly formed vesicular structures are discussed in this review and illustrate the need to fully elucidate their contributions at the molecular and structural level. |
| first_indexed | 2024-03-10T16:52:40Z |
| format | Article |
| id | doaj.art-1de25a426f924f06b76620b00ac9c372 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T16:52:40Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-1de25a426f924f06b76620b00ac9c3722023-11-20T11:13:47ZengMDPI AGBiomolecules2218-273X2020-08-01109123210.3390/biom10091232Galectins in Intra- and Extracellular VesiclesSebastian Bänfer0Ralf Jacob1Department of Cell Biology and Cell Pathology, Philipps-Universität Marburg, 35043 Marburg, GermanyDepartment of Cell Biology and Cell Pathology, Philipps-Universität Marburg, 35043 Marburg, GermanyCarbohydrate-binding galectins are expressed in various tissues of multicellular organisms. They are involved in autophagy, cell migration, immune response, inflammation, intracellular transport, and signaling. In recent years, novel roles of galectin-interaction with membrane components have been characterized, which lead to the formation of vesicles with diverse functions. These vesicles are part of intracellular transport pathways, belong to the cellular degradation machinery, or can be released for cell-to-cell communication. Several characteristics of galectins in the lumen or at the membrane of newly formed vesicular structures are discussed in this review and illustrate the need to fully elucidate their contributions at the molecular and structural level.https://www.mdpi.com/2218-273X/10/9/1232galectinnon-classical secretionendosomeexosomesorting |
| spellingShingle | Sebastian Bänfer Ralf Jacob Galectins in Intra- and Extracellular Vesicles Biomolecules galectin non-classical secretion endosome exosome sorting |
| title | Galectins in Intra- and Extracellular Vesicles |
| title_full | Galectins in Intra- and Extracellular Vesicles |
| title_fullStr | Galectins in Intra- and Extracellular Vesicles |
| title_full_unstemmed | Galectins in Intra- and Extracellular Vesicles |
| title_short | Galectins in Intra- and Extracellular Vesicles |
| title_sort | galectins in intra and extracellular vesicles |
| topic | galectin non-classical secretion endosome exosome sorting |
| url | https://www.mdpi.com/2218-273X/10/9/1232 |
| work_keys_str_mv | AT sebastianbanfer galectinsinintraandextracellularvesicles AT ralfjacob galectinsinintraandextracellularvesicles |