The Discovery of Dabigatran Etexilate

The Discovery of Dabigatran Etexilate

Thromboembolic disease is a major cause of mortality and morbidity in the developed world and is caused by an excessive stimulation of coagulation. Thrombin is a key serine protease in the coagulation cascade and numerous efforts have been made to develop safe and effective orally active direct thro...

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Bibliographic Details
Main Authors: Joanne evan Ryn, Ashley M Goss, Norbert eHauel, Wolfgang eWienen, Henning ePriepke, Herbert eNar, Andreas eClemens
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-02-01
Series:Frontiers in Pharmacology
Subjects:
Atrial Fibrillation
Stroke
Thrombin
Venous Thromboembolism
Warfarin
dabigatran
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00012/full

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