FDA Approved Drug Library Screening Identifies Robenidine as a Repositionable Antifungal

FDA Approved Drug Library Screening Identifies Robenidine as a Repositionable Antifungal

Due to the increasing prevalence of pathogenic fungal infections, the emergence of antifungal resistant clinical isolates worldwide, and the limited arsenal of available antifungals, developing new antifungal strategies is imperative. In this study, we screened a library of 1068 FDA-approved drugs t...

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Bibliographic Details
Main Authors: Yikun Mei, Tong Jiang, Yun Zou, Yuanyuan Wang, Jia Zhou, Jinyang Li, Lin Liu, Jingcong Tan, Luqi Wei, Jingquan Li, Huanqin Dai, Yibing Peng, Lixin Zhang, Jose L. Lopez-Ribot, Rebecca S. Shapiro, Changbin Chen, Ning-Ning Liu, Hui Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Microbiology
Subjects:
C. albicans
robenidine
filamentation
cell wall integrity
Rlm1
antifungal agents
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00996/full

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