Caloric restriction prevents obesity- and intermittent hypoxia-induced cardiac remodeling in leptin-deficient ob/ob mice

Caloric restriction prevents obesity- and intermittent hypoxia-induced cardiac remodeling in leptin-deficient ob/ob mice

Background: Intermittent hypoxia (IH), a key characteristic of obstructive sleep apnea, is independently associated with cardiometabolic impairment. While endogenous leptin levels may provide cardioprotective effects against hypoxia, leptin resistance is common among obese individuals presenting wit...

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Bibliographic Details
Main Authors: Aaron A. Jones, Sarah N. Framnes-DeBoer, Arianne Shipp, Deanna M. Arble
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Physiology
Subjects:
sleep apnea
leptin
obesity
intermittent hypoxia (IH)
caloric restriction
echocardiography
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.963762/full

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