An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability

An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability

Transcription factor (TF) networks determine cell-type identity by establishing and maintaining lineage-specific expression profiles, yet reconstruction of mammalian regulatory network models has been hampered by a lack of comprehensive functional validation of regulatory interactions. Here, we repo...

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Bibliographic Details
Main Authors: Judith Schütte, Huange Wang, Stella Antoniou, Andrew Jarratt, Nicola K Wilson, Joey Riepsaame, Fernando J Calero-Nieto, Victoria Moignard, Silvia Basilico, Sarah J Kinston, Rebecca L Hannah, Mun Chiang Chan, Sylvia T Nürnberg, Willem H Ouwehand, Nicola Bonzanni, Marella FTR de Bruijn, Berthold Göttgens
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-02-01
Series:eLife
Subjects:
regulatory network
single cell
stem cells
Online Access:https://elifesciences.org/articles/11469

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