Heat shock protein HSPA13 promotes hepatocellular carcinoma progression by stabilizing TANK
Abstract HSPA13, an important member of the heat shock protein family, plays an essential role in the oncogenesis of many organs, but the mechanism and function in hepatocellular carcinoma (HCC) is still unclear. In the present study, we found that HSPA13 was highly expressed in HCC and predicted po...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-12-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-023-01735-0 |
| _version_ | 1797398123822186496 |
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| author | Xuesong Cen Yuyan Lu Jing Lu Changhong Luo Ping Zhan Yizhe Cheng Fan Yang Chengrong Xie Zhenyu Yin Fuqiang Wang |
| author_facet | Xuesong Cen Yuyan Lu Jing Lu Changhong Luo Ping Zhan Yizhe Cheng Fan Yang Chengrong Xie Zhenyu Yin Fuqiang Wang |
| author_sort | Xuesong Cen |
| collection | DOAJ |
| description | Abstract HSPA13, an important member of the heat shock protein family, plays an essential role in the oncogenesis of many organs, but the mechanism and function in hepatocellular carcinoma (HCC) is still unclear. In the present study, we found that HSPA13 was highly expressed in HCC and predicted poor clinical prognosis. Upregulation of HSPA13 was significantly associated with vascular invasion in HCC patients. Functionally, knockdown experiments demonstrated that HSPA13 promoted HCC proliferation, migration, and invasion. Mechanistic investigation showed that HSPA13 could interact with TANK to inhibit its ubiquitination and degradation. In addition, the expression of HSPA13 and TANK were positively correlated in HCC tissues. To conclude, the present study uncovers the oncogenic function of HSPA13 in the progression of HCC by regulating the stability of TANK. These findings suggest that HSPA13 and TANK may serve as promising targets for the diagnosis and treatment of HCC. |
| first_indexed | 2024-03-09T01:21:12Z |
| format | Article |
| id | doaj.art-1de84c7320a3450ea9dfffbdd4b825b4 |
| institution | Directory Open Access Journal |
| issn | 2058-7716 |
| language | English |
| last_indexed | 2024-03-09T01:21:12Z |
| publishDate | 2023-12-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj.art-1de84c7320a3450ea9dfffbdd4b825b42023-12-10T12:07:41ZengNature Publishing GroupCell Death Discovery2058-77162023-12-019111010.1038/s41420-023-01735-0Heat shock protein HSPA13 promotes hepatocellular carcinoma progression by stabilizing TANKXuesong Cen0Yuyan Lu1Jing Lu2Changhong Luo3Ping Zhan4Yizhe Cheng5Fan Yang6Chengrong Xie7Zhenyu Yin8Fuqiang Wang9Department of Hepatobiliary Surgery, Xiamen Key Laboratory of Liver Diseases, Xiamen Hospital of Traditional Chinese Medicine, Beijing University of Chinese MedicineXiamen Translational Medical Key Laboratory of Digestive System Tumor, Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen UniversityXiamen Translational Medical Key Laboratory of Digestive System Tumor, Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen UniversityXiamen Translational Medical Key Laboratory of Digestive System Tumor, Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen UniversityXiamen Translational Medical Key Laboratory of Digestive System Tumor, Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen UniversityXiamen Translational Medical Key Laboratory of Digestive System Tumor, Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen UniversityXiamen Translational Medical Key Laboratory of Digestive System Tumor, Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen UniversityXiamen Translational Medical Key Laboratory of Digestive System Tumor, Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Hepatobiliary Surgery, Xiamen Key Laboratory of Liver Diseases, Xiamen Hospital of Traditional Chinese Medicine, Beijing University of Chinese MedicineDepartment of Hepatobiliary Surgery, Xiamen Key Laboratory of Liver Diseases, Xiamen Hospital of Traditional Chinese Medicine, Beijing University of Chinese MedicineAbstract HSPA13, an important member of the heat shock protein family, plays an essential role in the oncogenesis of many organs, but the mechanism and function in hepatocellular carcinoma (HCC) is still unclear. In the present study, we found that HSPA13 was highly expressed in HCC and predicted poor clinical prognosis. Upregulation of HSPA13 was significantly associated with vascular invasion in HCC patients. Functionally, knockdown experiments demonstrated that HSPA13 promoted HCC proliferation, migration, and invasion. Mechanistic investigation showed that HSPA13 could interact with TANK to inhibit its ubiquitination and degradation. In addition, the expression of HSPA13 and TANK were positively correlated in HCC tissues. To conclude, the present study uncovers the oncogenic function of HSPA13 in the progression of HCC by regulating the stability of TANK. These findings suggest that HSPA13 and TANK may serve as promising targets for the diagnosis and treatment of HCC.https://doi.org/10.1038/s41420-023-01735-0 |
| spellingShingle | Xuesong Cen Yuyan Lu Jing Lu Changhong Luo Ping Zhan Yizhe Cheng Fan Yang Chengrong Xie Zhenyu Yin Fuqiang Wang Heat shock protein HSPA13 promotes hepatocellular carcinoma progression by stabilizing TANK Cell Death Discovery |
| title | Heat shock protein HSPA13 promotes hepatocellular carcinoma progression by stabilizing TANK |
| title_full | Heat shock protein HSPA13 promotes hepatocellular carcinoma progression by stabilizing TANK |
| title_fullStr | Heat shock protein HSPA13 promotes hepatocellular carcinoma progression by stabilizing TANK |
| title_full_unstemmed | Heat shock protein HSPA13 promotes hepatocellular carcinoma progression by stabilizing TANK |
| title_short | Heat shock protein HSPA13 promotes hepatocellular carcinoma progression by stabilizing TANK |
| title_sort | heat shock protein hspa13 promotes hepatocellular carcinoma progression by stabilizing tank |
| url | https://doi.org/10.1038/s41420-023-01735-0 |
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