The 'COmorBidity in Relation to AIDS' (COBRA) cohort: Design, methods and participant characteristics.
Persons living with HIV on combination antiretroviral therapy (cART) may be at increased risk of the development of age-associated non-communicable comorbidities (AANCC) at relatively young age. It has therefore been hypothesised that such individuals, despite effective cART, may be prone to acceler...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5875743?pdf=render |
| _version_ | 1819268020044824576 |
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| author | Davide De Francesco Ferdinand W Wit James H Cole Neeltje A Kootstra Alan Winston Caroline A Sabin Jonathan Underwood Rosan A van Zoest Judith Schouten Katherine W Kooij Maria Prins Giovanni Guaraldi Matthan W A Caan David Burger Claudio Franceschi Claude Libert Alexander Bürkle Peter Reiss COmorBidity in Relation to AIDS (COBRA) collaboration |
| author_facet | Davide De Francesco Ferdinand W Wit James H Cole Neeltje A Kootstra Alan Winston Caroline A Sabin Jonathan Underwood Rosan A van Zoest Judith Schouten Katherine W Kooij Maria Prins Giovanni Guaraldi Matthan W A Caan David Burger Claudio Franceschi Claude Libert Alexander Bürkle Peter Reiss COmorBidity in Relation to AIDS (COBRA) collaboration |
| author_sort | Davide De Francesco |
| collection | DOAJ |
| description | Persons living with HIV on combination antiretroviral therapy (cART) may be at increased risk of the development of age-associated non-communicable comorbidities (AANCC) at relatively young age. It has therefore been hypothesised that such individuals, despite effective cART, may be prone to accelerated aging.The COmorBidity in Relation to AIDS (COBRA) cohort study was designed to investigate the potential causal link between HIV and AANCC, amongst others, in a cohort of middle-aged individuals with HIV with sustained viral suppression on cART and otherwise comparable HIV-negative controls.Longitudinal cohort study of HIV-positive subjects ≥45 years of age, with sustained HIV suppression on cART recruited from two large European HIV treatment centres and similarly-aged HIV-negative controls recruited from sexual health centres and targeted community groups. Both HIV-positive and HIV-negative subjects were assessed at study entry and again at follow-up after 2 years.Of the 134 HIV-positive individuals with a median (IQR) age of 56 (51, 62) years recruited, 93% were male, 88% of white ethnicity and 86% were men who have sex with men (MSM). Similarly, the 79 HIV-negative subjects had a median (IQR) age of 57 (52, 64) and 92% were male, 97% of white ethnicity and 80% were MSM.The results from the COBRA study will be a significant resource to understand the link between HIV and AANCC and the pathogenic mechanisms underlying this link. COBRA will inform future development of novel prognostic tools for earlier diagnosis of AANCC and of novel interventions which, as an adjunct to cART, may prevent AANCC. |
| first_indexed | 2024-12-23T21:26:25Z |
| format | Article |
| id | doaj.art-1de861200012415ea1f5d502ef368b0d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T21:26:25Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-1de861200012415ea1f5d502ef368b0d2022-12-21T17:30:35ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01133e019179110.1371/journal.pone.0191791The 'COmorBidity in Relation to AIDS' (COBRA) cohort: Design, methods and participant characteristics.Davide De FrancescoFerdinand W WitJames H ColeNeeltje A KootstraAlan WinstonCaroline A SabinJonathan UnderwoodRosan A van ZoestJudith SchoutenKatherine W KooijMaria PrinsGiovanni GuaraldiMatthan W A CaanDavid BurgerClaudio FranceschiClaude LibertAlexander BürklePeter ReissCOmorBidity in Relation to AIDS (COBRA) collaborationPersons living with HIV on combination antiretroviral therapy (cART) may be at increased risk of the development of age-associated non-communicable comorbidities (AANCC) at relatively young age. It has therefore been hypothesised that such individuals, despite effective cART, may be prone to accelerated aging.The COmorBidity in Relation to AIDS (COBRA) cohort study was designed to investigate the potential causal link between HIV and AANCC, amongst others, in a cohort of middle-aged individuals with HIV with sustained viral suppression on cART and otherwise comparable HIV-negative controls.Longitudinal cohort study of HIV-positive subjects ≥45 years of age, with sustained HIV suppression on cART recruited from two large European HIV treatment centres and similarly-aged HIV-negative controls recruited from sexual health centres and targeted community groups. Both HIV-positive and HIV-negative subjects were assessed at study entry and again at follow-up after 2 years.Of the 134 HIV-positive individuals with a median (IQR) age of 56 (51, 62) years recruited, 93% were male, 88% of white ethnicity and 86% were men who have sex with men (MSM). Similarly, the 79 HIV-negative subjects had a median (IQR) age of 57 (52, 64) and 92% were male, 97% of white ethnicity and 80% were MSM.The results from the COBRA study will be a significant resource to understand the link between HIV and AANCC and the pathogenic mechanisms underlying this link. COBRA will inform future development of novel prognostic tools for earlier diagnosis of AANCC and of novel interventions which, as an adjunct to cART, may prevent AANCC.http://europepmc.org/articles/PMC5875743?pdf=render |
| spellingShingle | Davide De Francesco Ferdinand W Wit James H Cole Neeltje A Kootstra Alan Winston Caroline A Sabin Jonathan Underwood Rosan A van Zoest Judith Schouten Katherine W Kooij Maria Prins Giovanni Guaraldi Matthan W A Caan David Burger Claudio Franceschi Claude Libert Alexander Bürkle Peter Reiss COmorBidity in Relation to AIDS (COBRA) collaboration The 'COmorBidity in Relation to AIDS' (COBRA) cohort: Design, methods and participant characteristics. PLoS ONE |
| title | The 'COmorBidity in Relation to AIDS' (COBRA) cohort: Design, methods and participant characteristics. |
| title_full | The 'COmorBidity in Relation to AIDS' (COBRA) cohort: Design, methods and participant characteristics. |
| title_fullStr | The 'COmorBidity in Relation to AIDS' (COBRA) cohort: Design, methods and participant characteristics. |
| title_full_unstemmed | The 'COmorBidity in Relation to AIDS' (COBRA) cohort: Design, methods and participant characteristics. |
| title_short | The 'COmorBidity in Relation to AIDS' (COBRA) cohort: Design, methods and participant characteristics. |
| title_sort | comorbidity in relation to aids cobra cohort design methods and participant characteristics |
| url | http://europepmc.org/articles/PMC5875743?pdf=render |
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