Brexpiprazole—Pharmacologic Properties and Use in Schizophrenia and Mood Disorders
In 2002, the first III generation antipsychotic drug was registered—aripiprazole. Its partial dopaminergic agonism underlies its unique mechanism of action and the potentially beneficial influence on the positive, negative, or cognitive symptoms. Due to its relatively high intrinsic activity, the dr...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/3/397 |
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| author | Marcin Siwek Krzysztof Wojtasik-Bakalarz Anna Julia Krupa Adrian Andrzej Chrobak |
| author_facet | Marcin Siwek Krzysztof Wojtasik-Bakalarz Anna Julia Krupa Adrian Andrzej Chrobak |
| author_sort | Marcin Siwek |
| collection | DOAJ |
| description | In 2002, the first III generation antipsychotic drug was registered—aripiprazole. Its partial dopaminergic agonism underlies its unique mechanism of action and the potentially beneficial influence on the positive, negative, or cognitive symptoms. Due to its relatively high intrinsic activity, the drug could often cause agitation, anxiety, or akathisia. For this reason, efforts were made to develop a drug which would retain the positive favorable actions of aripiprazole but present a more advantageous clinical profile. This turned out to be brexpiprazole, which was registered in 2015. Its pharmacodynamic and pharmacokinetic profile (similarly to the other most recent antipsychotics, i.e., lurasidone or cariprazine) shows promise of increasing the effectiveness of schizophrenia treatment in the dimensions in which the previous antipsychotics were not sufficiently effective, including negative, depressive, or cognitive symptoms. Like other new antipsychotics, it can also be useful in the treatment of mood disorders, for instance drug-resistant depression. Previous reviews focused on the use of brexpiprazole in specific diagnostic groups. The aim of this article is to provide the readers with an overview of data on the mechanism of action, clinical effectiveness in all studied diagnostic groups, as well as potential drug–food interactions, and the safety of brexpiprazole. |
| first_indexed | 2024-03-11T06:50:19Z |
| format | Article |
| id | doaj.art-1de981ce8a92450291d5bb1a3ba33131 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T06:50:19Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-1de981ce8a92450291d5bb1a3ba331312023-11-17T09:59:16ZengMDPI AGBrain Sciences2076-34252023-02-0113339710.3390/brainsci13030397Brexpiprazole—Pharmacologic Properties and Use in Schizophrenia and Mood DisordersMarcin Siwek0Krzysztof Wojtasik-Bakalarz1Anna Julia Krupa2Adrian Andrzej Chrobak3Department of Affective Disorders, Jagiellonian University Medical College, Kopernika St. 21a, 31-501 Cracow, PolandDepartment of Affective Disorders, Jagiellonian University Medical College, Kopernika St. 21a, 31-501 Cracow, PolandDepartment of Psychiatry, Jagiellonian University Medical College, Kopernika St. 21a, 31-501 Cracow, PolandDepartment of Adult Psychiatry, Jagiellonian University Medical College, Kopernika St. 21a, 31-501 Cracow, PolandIn 2002, the first III generation antipsychotic drug was registered—aripiprazole. Its partial dopaminergic agonism underlies its unique mechanism of action and the potentially beneficial influence on the positive, negative, or cognitive symptoms. Due to its relatively high intrinsic activity, the drug could often cause agitation, anxiety, or akathisia. For this reason, efforts were made to develop a drug which would retain the positive favorable actions of aripiprazole but present a more advantageous clinical profile. This turned out to be brexpiprazole, which was registered in 2015. Its pharmacodynamic and pharmacokinetic profile (similarly to the other most recent antipsychotics, i.e., lurasidone or cariprazine) shows promise of increasing the effectiveness of schizophrenia treatment in the dimensions in which the previous antipsychotics were not sufficiently effective, including negative, depressive, or cognitive symptoms. Like other new antipsychotics, it can also be useful in the treatment of mood disorders, for instance drug-resistant depression. Previous reviews focused on the use of brexpiprazole in specific diagnostic groups. The aim of this article is to provide the readers with an overview of data on the mechanism of action, clinical effectiveness in all studied diagnostic groups, as well as potential drug–food interactions, and the safety of brexpiprazole.https://www.mdpi.com/2076-3425/13/3/397antipsychotic drugsbrexipiprazoleadverse effects |
| spellingShingle | Marcin Siwek Krzysztof Wojtasik-Bakalarz Anna Julia Krupa Adrian Andrzej Chrobak Brexpiprazole—Pharmacologic Properties and Use in Schizophrenia and Mood Disorders Brain Sciences antipsychotic drugs brexipiprazole adverse effects |
| title | Brexpiprazole—Pharmacologic Properties and Use in Schizophrenia and Mood Disorders |
| title_full | Brexpiprazole—Pharmacologic Properties and Use in Schizophrenia and Mood Disorders |
| title_fullStr | Brexpiprazole—Pharmacologic Properties and Use in Schizophrenia and Mood Disorders |
| title_full_unstemmed | Brexpiprazole—Pharmacologic Properties and Use in Schizophrenia and Mood Disorders |
| title_short | Brexpiprazole—Pharmacologic Properties and Use in Schizophrenia and Mood Disorders |
| title_sort | brexpiprazole pharmacologic properties and use in schizophrenia and mood disorders |
| topic | antipsychotic drugs brexipiprazole adverse effects |
| url | https://www.mdpi.com/2076-3425/13/3/397 |
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