Magnesium supplementation and insulin resistance in patients with rheumatoid arthritis
Rheumatoid arthritis (RA) is a multifactorial disease affecting the immune system and many tissues in the body. This study aimed to evaluate the effect of magnesium supplementation on insulin resistance and fasting blood sugar (FBS) of patients with RA. In this prospective uncontrolled before-after...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2022-07-01
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| Series: | European Journal of Translational Myology |
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| Online Access: | https://www.pagepressjournals.org/index.php/bam/article/view/10622 |
| _version_ | 1811325034309877760 |
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| author | Mohsen Norouzi Boshra Rezvankhah Mohammad Reza Haeri Hosein Heydari Javad Tafaroji Navid Shafigh Jamshid Ordoni Avval Alireza Rahat Dahmardeh Niyoosha Masoumzadeh Mohammad Gharehbeglou |
| author_facet | Mohsen Norouzi Boshra Rezvankhah Mohammad Reza Haeri Hosein Heydari Javad Tafaroji Navid Shafigh Jamshid Ordoni Avval Alireza Rahat Dahmardeh Niyoosha Masoumzadeh Mohammad Gharehbeglou |
| author_sort | Mohsen Norouzi |
| collection | DOAJ |
| description |
Rheumatoid arthritis (RA) is a multifactorial disease affecting the immune system and many tissues in the body. This study aimed to evaluate the effect of magnesium supplementation on insulin resistance and fasting blood sugar (FBS) of patients with RA. In this prospective uncontrolled before-after study, RA patients referring to Rheumatology clinics of Qom City from January 2020 to January 2021 were evaluated. First, the patients received the routine rheumatoid arthritis treatment including 5 mg Prednisolone and 200mg Hydroxychloroquine daily for 6 months and FBS and insulin levels were measured after. Then, they received the routine arthritis rheumatoid treatment in addition to 300 mg/day oral Magnesium sulfate for 6 months and then, FBS and insulin levels were measured. The Homeostasis Model Assessment of insulin resistance (HOMA-IR) was used for determining insulin resistance. Thirty five patients with RA and the mean age of 49.83±2.58 years were enrolled. Twenty eight cases (80%) were female and 7 cases (20%) were male. The mean HOMA-IR before and after consumption of oral magnesium were 3.04±0.29 and 2.43±0.19, respectively. Statistically significant differences were found between FBS, insulin and HOMA-IR before and after consumption of oral magnesium (p<0.05). Our data suggested that magnesium supplementation reduces FBS, insulin and HOMA-IR in patients with rheumatoid arthritis. Thus, magnesium supplements may be an alternative method for prevention of type 2 diabetes in RA patients.
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| first_indexed | 2024-04-13T14:26:00Z |
| format | Article |
| id | doaj.art-1deb644d31f14e099961def4f6829530 |
| institution | Directory Open Access Journal |
| issn | 2037-7452 2037-7460 |
| language | English |
| last_indexed | 2024-04-13T14:26:00Z |
| publishDate | 2022-07-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | European Journal of Translational Myology |
| spelling | doaj.art-1deb644d31f14e099961def4f68295302022-12-22T02:43:18ZengPAGEPress PublicationsEuropean Journal of Translational Myology2037-74522037-74602022-07-0110.4081/ejtm.2022.10622Magnesium supplementation and insulin resistance in patients with rheumatoid arthritisMohsen Norouzi0Boshra Rezvankhah1Mohammad Reza Haeri2Hosein Heydari3Javad Tafaroji4Navid Shafigh5Jamshid Ordoni Avval6Alireza Rahat Dahmardeh7Niyoosha Masoumzadeh8Mohammad Gharehbeglou9Department of Internal Medicine, School of Medicine, Qom Branch, Islamic Azad University, QomResearch Institute for Endocrine Sciences, Shahid Beheshti University of Medical Science, TehranDepartment of Biochemistry, School of Medicine, Qom University of Medical Science, QomDepartment of Pediatrics, School of Medicine, Qom University of Medical Science, QomDepartment of Pediatrics, School of Medicine, Qom University of Medical Science, QomDepartment of Anesthesiology and critical Care Medicine, School of Medicine, Shahid Beheshti University of Medical Science, TehranDepartment of Anesthesiology and Critical Care Medicine, School of Medicine, Zahedan University of Medical Science, ZahedanDepartment of Anesthesiology and Critical Care Medicine, School of Medicine, Zahedan University of Medical Science, ZahedanDepartment of Infectious Disease and Tropical Medicine, School of Medicine, Zahedan University of Medical Science, Zahedan, Iran; Department of Infectious Disease and Tropical Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Science, TehranDepartment of Anesthesiology and critical Care Medicine, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran; Department of Anesthesiology and Critical Care Medicine, School of Medicine, Zahedan University of Medical Science, Zahedan Rheumatoid arthritis (RA) is a multifactorial disease affecting the immune system and many tissues in the body. This study aimed to evaluate the effect of magnesium supplementation on insulin resistance and fasting blood sugar (FBS) of patients with RA. In this prospective uncontrolled before-after study, RA patients referring to Rheumatology clinics of Qom City from January 2020 to January 2021 were evaluated. First, the patients received the routine rheumatoid arthritis treatment including 5 mg Prednisolone and 200mg Hydroxychloroquine daily for 6 months and FBS and insulin levels were measured after. Then, they received the routine arthritis rheumatoid treatment in addition to 300 mg/day oral Magnesium sulfate for 6 months and then, FBS and insulin levels were measured. The Homeostasis Model Assessment of insulin resistance (HOMA-IR) was used for determining insulin resistance. Thirty five patients with RA and the mean age of 49.83±2.58 years were enrolled. Twenty eight cases (80%) were female and 7 cases (20%) were male. The mean HOMA-IR before and after consumption of oral magnesium were 3.04±0.29 and 2.43±0.19, respectively. Statistically significant differences were found between FBS, insulin and HOMA-IR before and after consumption of oral magnesium (p<0.05). Our data suggested that magnesium supplementation reduces FBS, insulin and HOMA-IR in patients with rheumatoid arthritis. Thus, magnesium supplements may be an alternative method for prevention of type 2 diabetes in RA patients. https://www.pagepressjournals.org/index.php/bam/article/view/10622Magnesiuminsulin resistancerheumatoid arthritis |
| spellingShingle | Mohsen Norouzi Boshra Rezvankhah Mohammad Reza Haeri Hosein Heydari Javad Tafaroji Navid Shafigh Jamshid Ordoni Avval Alireza Rahat Dahmardeh Niyoosha Masoumzadeh Mohammad Gharehbeglou Magnesium supplementation and insulin resistance in patients with rheumatoid arthritis European Journal of Translational Myology Magnesium insulin resistance rheumatoid arthritis |
| title | Magnesium supplementation and insulin resistance in patients with rheumatoid arthritis |
| title_full | Magnesium supplementation and insulin resistance in patients with rheumatoid arthritis |
| title_fullStr | Magnesium supplementation and insulin resistance in patients with rheumatoid arthritis |
| title_full_unstemmed | Magnesium supplementation and insulin resistance in patients with rheumatoid arthritis |
| title_short | Magnesium supplementation and insulin resistance in patients with rheumatoid arthritis |
| title_sort | magnesium supplementation and insulin resistance in patients with rheumatoid arthritis |
| topic | Magnesium insulin resistance rheumatoid arthritis |
| url | https://www.pagepressjournals.org/index.php/bam/article/view/10622 |
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